Department of Biochemistry
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The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11782480
A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.
Nature structural biology Feb, 2003 | Pubmed ID: 12536206
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.
Genes & development Aug, 2003 | Pubmed ID: 12897056
Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12917445
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.
Endocrinology Apr, 2004 | Pubmed ID: 14657011
Nuclear receptors: the evolution of diversity.
Science's STKE : signal transduction knowledge environment Jan, 2004 | Pubmed ID: 14747695
Mechanism of the nuclear receptor molecular switch.
Trends in biochemical sciences Jun, 2004 | Pubmed ID: 15276186
Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15456745
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15837933
Structural basis for the activation of PPARgamma by oxidized fatty acids.
Nature structural & molecular biology Sep, 2008 | Pubmed ID: 19172745
Comparison of the molecular consequences of different mutations at residue 754 and 690 of the androgen receptor (AR) and androgen insensitivity syndrome (AIS) phenotype.
Clinical endocrinology Aug, 2009 | Pubmed ID: 19178528
Negative regulation by nuclear receptors: a plethora of mechanisms.
Trends in endocrinology and metabolism: TEM Mar, 2011 | Pubmed ID: 21196123
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nature structural & molecular biology Feb, 2011 | Pubmed ID: 21240272
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
Genes & development Jun, 2011 | Pubmed ID: 21685362
Nuclear hormone receptor co-repressors: structure and function.
Molecular and cellular endocrinology Jan, 2012 | Pubmed ID: 21925568
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22109552
A mutation in the thyroid hormone receptor alpha gene.
The New England journal of medicine Jan, 2012 | Pubmed ID: 22168587
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.
Nature Jan, 2012 | Pubmed ID: 22230954
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.
Molecular cell Jul, 2012 | Pubmed ID: 22683266
Class I HDACs share a common mechanism of regulation by inositol phosphates.
Molecular cell Jul, 2013 | Pubmed ID: 23791785
Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).
Molecular biology of the cell Nov, 2013 | Pubmed ID: 24006493
An evolving understanding of nuclear receptor coregulator proteins.
Journal of molecular endocrinology Dec, 2013 | Pubmed ID: 24203923
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.
PloS one , 2014 | Pubmed ID: 24595451
Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 24958871
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