John W.R. Schwabe

The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.

Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor.

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

Nuclear receptors: the evolution of diversity.

Mechanism of the nuclear receptor molecular switch.

Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.

Structural basis for the activation of PPARgamma by oxidized fatty acids.

Comparison of the molecular consequences of different mutations at residue 754 and 690 of the androgen receptor (AR) and androgen insensitivity syndrome (AIS) phenotype.

Negative regulation by nuclear receptors: a plethora of mechanisms.

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

Nuclear hormone receptor co-repressors: structure and function.

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

A mutation in the thyroid hormone receptor alpha gene.

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.

A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.

Class I HDACs share a common mechanism of regulation by inositol phosphates.

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).

An evolving understanding of nuclear receptor coregulator proteins.

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.