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Department of Pathology
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Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus.
Journal of virology Jun, 2005 | Pubmed ID: 15919884
Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains.
Journal of virology Jul, 2005 | Pubmed ID: 15956579
A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.
Virology Jun, 2006 | Pubmed ID: 16624366
Avian virulence and thermostable replication of the North American strain of West Nile virus.
The Journal of general virology Dec, 2006 | Pubmed ID: 17098976
A combination of naturally occurring mutations in North American West Nile virus nonstructural protein genes and in the 3' untranslated region alters virus phenotype.
Journal of virology Jun, 2007 | Pubmed ID: 17376926
Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus.
Vaccine Jan, 2010 | Pubmed ID: 19896447
Characterization of TEM1/endosialin in human and murine brain tumors.
BMC cancer , 2009 | Pubmed ID: 19948061
Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain.
Vaccine Jun, 2011 | Pubmed ID: 21549792
Multiple amino acid changes at the first glycosylation motif in NS1 protein of West Nile virus are necessary for complete attenuation for mouse neuroinvasiveness.
Vaccine Dec, 2011 | Pubmed ID: 21945257
Mutational analysis of the West Nile virus NS4B protein.
Virology Apr, 2012 | Pubmed ID: 22314017
Vertebrate attenuated West Nile virus mutants have differing effects on vector competence in Culex tarsalis mosquitoes.
The Journal of general virology May, 2013 | Pubmed ID: 23303828
A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.
Vaccine Aug, 2013 | Pubmed ID: 23845800
Attenuated West Nile virus mutant NS1130-132QQA/175A/207A exhibits virus-induced ultrastructural changes and accumulation of protein in the Endoplasmic Reticulum.
Journal of virology Nov, 2014 | Pubmed ID: 25392222
The University of Texas Medical Branch
Guorui Xie1,
Melissa C. Whiteman2,
Jason A. Wicker2,
Alan D.T. Barrett1,2,3,
Tian Wang1,2,3
1Department of Microbiology & Immunology, The University of Texas Medical Branch,
2Department of Pathology, The University of Texas Medical Branch,
3Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, The University of Texas Medical Branch
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