Peiying Liu

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.

Determination of spin compartment in arterial spin labeling MRI.

Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness.

Validation of VASO cerebral blood volume measurement with positron emission tomography.

Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation.

On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRI.

Comparison of relative cerebral blood flow maps using pseudo-continuous arterial spin labeling and single photon emission computed tomography.

A comparison of physiologic modulators of fMRI signals.

Test-retest reproducibility of a rapid method to measure brain oxygen metabolism.

Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism.

Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2.

Vessel-specific quantification of blood oxygenation with T2 -relaxation-under-phase-contrast MRI.

Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.

Dependence of blood T(2) on oxygenation at 7 T: in vitro calibration and in vivo application.

Physiologic underpinnings of negative BOLD cerebrovascular reactivity in brain ventricles.

Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects.

Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI.

MRI assessment of cerebral oxygen metabolism in cocaine-addicted individuals: hypoactivity and dose dependence.

Automatic and reproducible positioning of phase-contrast MRI for the quantification of global cerebral blood flow.

Age-related increase of resting metabolic rate in the human brain.

Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques.

Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement.

Impaired cerebrovascular reactivity in multiple sclerosis.

Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism.