Advanced Imaging Research Center
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Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
Journal of medicinal chemistry Sep, 2005 | Pubmed ID: 16134929
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.
Bioorganic & medicinal chemistry letters Sep, 2006 | Pubmed ID: 16806919
Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).
Bioorganic & medicinal chemistry letters Apr, 2007 | Pubmed ID: 17317169
Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.
Bioorganic & medicinal chemistry letters Jun, 2007 | Pubmed ID: 17398093
Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.
Journal of medicinal chemistry Oct, 2008 | Pubmed ID: 18763755
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
Journal of medicinal chemistry Dec, 2009 | Pubmed ID: 19778024
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Bioorganic & medicinal chemistry letters May, 2010 | Pubmed ID: 20399649
Determination of spin compartment in arterial spin labeling MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jan, 2011 | Pubmed ID: 20740655
Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness.
Neurotoxicology Mar, 2011 | Pubmed ID: 21147163
Validation of VASO cerebral blood volume measurement with positron emission tomography.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Mar, 2011 | Pubmed ID: 21337407
Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jan, 2012 | Pubmed ID: 21590721
On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jul, 2012 | Pubmed ID: 22127845
Comparison of relative cerebral blood flow maps using pseudo-continuous arterial spin labeling and single photon emission computed tomography.
NMR in biomedicine May, 2012 | Pubmed ID: 22139764
A comparison of physiologic modulators of fMRI signals.
Human brain mapping Sep, 2013 | Pubmed ID: 22461234
Test-retest reproducibility of a rapid method to measure brain oxygen metabolism.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Mar, 2013 | Pubmed ID: 22517498
Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2012 | Pubmed ID: 22739621
Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2.
Journal of magnetic resonance imaging : JMRI Nov, 2013 | Pubmed ID: 23526811
Vessel-specific quantification of blood oxygenation with T2 -relaxation-under-phase-contrast MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Apr, 2013 | Pubmed ID: 23568830
Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.
NeuroImage Sep, 2013 | Pubmed ID: 23624491
Dependence of blood T(2) on oxygenation at 7 T: in vitro calibration and in vivo application.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Jun, 2014 | Pubmed ID: 23843129
Physiologic underpinnings of negative BOLD cerebrovascular reactivity in brain ventricles.
NeuroImage Dec, 2013 | Pubmed ID: 23851322
Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2014 | Pubmed ID: 24192640
Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI.
NMR in biomedicine Mar, 2014 | Pubmed ID: 24399806
MRI assessment of cerebral oxygen metabolism in cocaine-addicted individuals: hypoactivity and dose dependence.
NMR in biomedicine Jun, 2014 | Pubmed ID: 24757009
Automatic and reproducible positioning of phase-contrast MRI for the quantification of global cerebral blood flow.
PloS one , 2014 | Pubmed ID: 24787742
Age-related increase of resting metabolic rate in the human brain.
NeuroImage Sep, 2014 | Pubmed ID: 24814209
Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques.
Early human development Oct, 2014 | Pubmed ID: 25028136
Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement.
JAMA neurology Oct, 2014 | Pubmed ID: 25110966
Impaired cerebrovascular reactivity in multiple sclerosis.
JAMA neurology Oct, 2014 | Pubmed ID: 25133874
Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism.
Human brain mapping Oct, 2014 | Pubmed ID: 25324201
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