Ottavio Arancio

Calpain inhibitors: a treatment for Alzheimer's disease.

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.

Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.

Calpain inhibitors, a treatment for Alzheimer's disease: position paper.

Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice.

Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy.

Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.

alpha-Synuclein produces a long-lasting increase in neurotransmitter release.

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment.

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.

Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease.

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome.

BDNF-mediated neurotransmission relies upon a myosin VI motor complex.

Fibrillar beta-amyloid impairs the late phase of long term potentiation.

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.

Early presynaptic changes during plasticity in cultured hippocampal neurons.

Estimation of the mean from sums with unknown numbers of summands.

Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease.

Neurotrophins, synaptic plasticity and dementia.

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII.

Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.

A GluR1-cGKII interaction regulates AMPA receptor trafficking.

A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.

Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons.

RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease.

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism.

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

Isolation and characterization of "Reprotoxin", a novel protein complex from Daboia russelii snake venom.

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome.

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity.

Role of phosphodiesterase 5 in synaptic plasticity and memory.

Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons.

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.

Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE.

Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration.

Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.

Reversal of long-term dendritic spine alterations in Alzheimer disease models.

MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.

The ARMS/Kidins220 scaffold protein modulates synaptic transmission.

PIP2: a new key player in Alzheimer's disease.

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex.

The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons.

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.