Taub Institute for Research on Alzheimer's Disease and Aging Brain
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Calpain inhibitors: a treatment for Alzheimer's disease.
Journal of molecular neuroscience : MN Aug-Oct, 2002 | Pubmed ID: 12212771
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12244210
Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.
Neurochemical research Jul, 2003 | Pubmed ID: 12737525
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.
Science (New York, N.Y.) Aug, 2003 | Pubmed ID: 12907793
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.
The EMBO journal Aug, 2003 | Pubmed ID: 12912911
Calpain inhibitors, a treatment for Alzheimer's disease: position paper.
Journal of molecular neuroscience : MN , 2003 | Pubmed ID: 14501020
Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.
Neuron Apr, 2004 | Pubmed ID: 15066270
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science (New York, N.Y.) Apr, 2004 | Pubmed ID: 15087549
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice.
Annals of neurology Jun, 2004 | Pubmed ID: 15174014
Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy.
Journal of molecular neuroscience : MN , 2004 | Pubmed ID: 15314245
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.
The American journal of pathology Sep, 2004 | Pubmed ID: 15331404
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
The EMBO journal Oct, 2004 | Pubmed ID: 15457210
alpha-Synuclein produces a long-lasting increase in neurotransmitter release.
The EMBO journal Nov, 2004 | Pubmed ID: 15510220
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment.
The Journal of clinical investigation Dec, 2004 | Pubmed ID: 15578094
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2005 | Pubmed ID: 15665036
Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease.
Current Alzheimer research Apr, 2005 | Pubmed ID: 15974910
Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2005 | Pubmed ID: 16033898
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16399702
BDNF-mediated neurotransmission relies upon a myosin VI motor complex.
Nature neuroscience Aug, 2006 | Pubmed ID: 16819522
Fibrillar beta-amyloid impairs the late phase of long term potentiation.
Current Alzheimer research Jul, 2006 | Pubmed ID: 16842092
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.
Cell Aug, 2006 | Pubmed ID: 16923396
Early presynaptic changes during plasticity in cultured hippocampal neurons.
The EMBO journal Sep, 2006 | Pubmed ID: 16957772
Estimation of the mean from sums with unknown numbers of summands.
Biometrics Sep, 2006 | Pubmed ID: 16984336
Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease.
Reviews in the neurosciences , 2006 | Pubmed ID: 17180876
Neurotrophins, synaptic plasticity and dementia.
Current opinion in neurobiology Jun, 2007 | Pubmed ID: 17419049
Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII.
The European journal of neuroscience Jun, 2007 | Pubmed ID: 17610578
Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.
Neurobiology of aging Feb, 2009 | Pubmed ID: 17640772
A GluR1-cGKII interaction regulates AMPA receptor trafficking.
Neuron Nov, 2007 | Pubmed ID: 18031684
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics Apr, 2008 | Pubmed ID: 18199809
Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons.
Current Alzheimer research Dec, 2007 | Pubmed ID: 18220514
RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease.
Current molecular medicine Dec, 2007 | Pubmed ID: 18331231
Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2008 | Pubmed ID: 18367618
Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism.
Nature neuroscience May, 2008 | Pubmed ID: 18391946
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.
Proceedings of the National Academy of Sciences of the United States of America May, 2008 | Pubmed ID: 18480253
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.
Neurobiology of disease Jul, 2008 | Pubmed ID: 18504134
Isolation and characterization of "Reprotoxin", a novel protein complex from Daboia russelii snake venom.
Biochimie Oct, 2008 | Pubmed ID: 18573307
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18591654
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
The Journal of clinical investigation Aug, 2008 | Pubmed ID: 18596919
A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity.
Channels (Austin, Tex.) Jul-Aug, 2008 | Pubmed ID: 18728399
Role of phosphodiesterase 5 in synaptic plasticity and memory.
Neuropsychiatric disease and treatment Apr, 2008 | Pubmed ID: 18728748
Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons.
Journal of neurochemistry Nov, 2008 | Pubmed ID: 18796007
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Nature medicine Oct, 2008 | Pubmed ID: 18806802
Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.
PloS one , 2008 | Pubmed ID: 18978948
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2008 | Pubmed ID: 19118188
Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19221410
Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration.
Mini reviews in medicinal chemistry Apr, 2009 | Pubmed ID: 19356123
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Sep, 2009 | Pubmed ID: 19516252
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2009 | Pubmed ID: 19553447
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19625751
Reversal of long-term dendritic spine alterations in Alzheimer disease models.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19805389
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
Expert review of neurotherapeutics Nov, 2009 | Pubmed ID: 19903023
The ARMS/Kidins220 scaffold protein modulates synaptic transmission.
Molecular and cellular neurosciences Oct, 2010 | Pubmed ID: 20547223
PIP2: a new key player in Alzheimer's disease.
Cellscience Jul, 2008 | Pubmed ID: 20577650
Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2010 | Pubmed ID: 20739563
The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.
The Journal of biological chemistry Dec, 2010 | Pubmed ID: 20943655
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2010 | Pubmed ID: 21048150
Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21098268
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2010 | Pubmed ID: 21147981
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2011 | Pubmed ID: 21307267
A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons.
Experimental neurology Jun, 2011 | Pubmed ID: 21419124
Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.
Annals of neurology May, 2011 | Pubmed ID: 21472769
APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.
The EMBO journal Jun, 2011 | Pubmed ID: 21587206
β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.
EMBO molecular medicine Dec, 2011 | Pubmed ID: 22170863