V. Wee Yong

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis.

A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis.

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis.

Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury.

Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod.

Immune cell infiltrates in atypical teratoid/rhabdoid tumors.

Prolactin in multiple sclerosis.

Susceptibility-weighted imaging in the experimental autoimmune encephalomyelitis model of multiple sclerosis indicates elevated deoxyhemoglobin, iron deposition and demyelination.

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination.

Remyelination therapy for multiple sclerosis.

Cortical remyelination: a new target for repair therapies in multiple sclerosis.

Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms.

Environmental factors and their regulation of immunity in multiple sclerosis.

Reply: To PMID 23034914.

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.

A prospective evaluation of the temporal matrix metalloproteinase response after severe traumatic brain injury in humans.

Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

Association between the cerebral inflammatory and matrix metalloproteinase responses after severe traumatic brain injury in humans.

The benefits and detriments of macrophages/microglia in models of multiple sclerosis.

Reduction of microglial activity in a model of multiple sclerosis by dipyridamole.

Treatment trials in progressive MS--current challenges and future directions.

Pathophysiology of the brain extracellular matrix: a new target for remyelination.

Screening for inhibitors of microglia to reduce neuroinflammation.

High-resolution fluorescence microscopy of myelin without exogenous probes.

The regulation of reactive changes around multiple sclerosis lesions by phosphorylated signal transducer and activator of transcription.

Active inflammation increases the heterogeneity of MRI texture in mice with relapsing experimental allergic encephalomyelitis.

Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis.

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells.

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.

Remyelination after spinal cord injury: is it a target for repair?

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome.

Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models.

Iron in multiple sclerosis: roles in neurodegeneration and repair.

Interactions between microglia and T cells in multiple sclerosis pathobiology.

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells.

Changes in tissue directionality reflect differences in myelin content after demyelination in mice spinal cords.

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus.

The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages.

Laquinimod reduces neuroaxonal injury through inhibiting microglial activation.

Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination.

EMMPRIN, an upstream regulator of MMPs, in CNS biology.

ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor-initiating cells.

The promise of futility trials in neurological diseases.

Inefficient clearance of myelin debris by microglia impairs remyelinating processes.

Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.

Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression.

Metalloproteinases in biology and pathology of the nervous system.

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase.

The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation.

Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.

White matter plasticity and enhanced remyelination in the maternal CNS.

Targeting MMPs in acute and chronic neurological conditions.

Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome.

Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental autoimmune encephalomyelitis in association with cytokine and chemokine dysregulation.

Multiexponential T2 and magnetization transfer MRI of demyelination and remyelination in murine spinal cord.

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate.

Taking advantage of the systemic immune system to cure brain diseases.

Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix.

The interplay between the immune and central nervous systems in neuronal injury.

Improving outcomes of neuroprotection by minocycline: guides from cell culture and intracerebral hemorrhage in mice.

Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties.

Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury.

Neuroinflammation and demyelination in multiple sclerosis after allogeneic hematopoietic stem cell transplantation.

Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice.

The many faces of EMMPRIN - roles in neuroinflammation.

EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis.

Analysis of the mitochondrial proteome in multiple sclerosis cortex.

Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism.

The good, the bad and the ugly. Macrophages/microglia with a focus on myelin repair.

Chondroitin sulphate proteoglycans: extracellular matrix proteins that regulate immunity of the central nervous system.

[Promoting remyelination by reducing an inhibitory microenvironment].

Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis.

The role of EMMPRIN in T cell biology and immunological diseases.

Detecting deoxyhemoglobin in spinal cord vasculature of the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis using susceptibility MRI and hyperoxygenation.

Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury.

1,25-Dihydroxyvitamin D3 Protects against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis.

Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types.

Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.

Expanding antigen-specific regulatory networks to treat autoimmunity.

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system.

Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis.

Demyelination induces transport of ribosome-containing vesicles from glia to axons: evidence from animal models and MS patient brains.

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination.

Regenerative Capacity of Macrophages for Remyelination.

Myeloid cells - targets of medication in multiple sclerosis.

MRI monitoring of monocytes to detect immune stimulating treatment response in brain tumor.

Evaluating Soluble EMMPRIN as a Marker of Disease Activity in Multiple Sclerosis: Studies of Serum and Cerebrospinal Fluid.

Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis.

T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints.

Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis.

Glioblastoma-associated microglia and macrophages: targets for therapies to improve prognosis.

Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells.

Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis.

Stop inflammation and you stop neurodegeneration in MS - YES.

Remyelination therapies: a new direction and challenge in multiple sclerosis.

Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?

Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy.

Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic.

Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Live Multiphoton Imaging.

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis.

The extracellular matrix: Focus on oligodendrocyte biology and targeting CSPGs for remyelination therapies.

Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system.

MR Imaging of Tumor-Associated Macrophages: The Next Frontier in Cancer Imaging.

Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis.

Cerebrospinal Fluid Biomarkers in Human Spinal Cord Injury from a Phase II Minocycline Trial.

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α.

Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity.

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome.

Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity.

Efficacy of Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Rodent and Clinical Studies.

The benefits of neuroinflammation for the repair of the injured central nervous system.

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.

Differential microglia and macrophage profiles in human IDH-mutant and -wild type glioblastoma.

Domperidone-induced elevation of serum prolactin levels and immune response in multiple sclerosis.

Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis.

Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity.

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies.

Targeting the Chondroitin Sulfate Proteoglycans: Evaluating Fluorinated Glucosamines and Xylosides in Screens Pertinent to Multiple Sclerosis.

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes.

When encephalitogenic T cells collaborate with microglia in multiple sclerosis.

2-arachidonoylglycerol reduces chondroitin sulphate proteoglycan production by astrocytes and enhances oligodendrocyte differentiation under inhibitory conditions.

Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities.

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion.

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.

Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes.

Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.

Control of brain tumor growth by reactivating myeloid cells with niacin.

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.

Author Correction: Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy.

Beyond barrier functions: Roles of pericytes in homeostasis and regulation of neuroinflammation.

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression.

Metabolic needs of brain-infiltrating leukocytes and microglia in multiple sclerosis.

Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide.

Exercise and the brain in multiple sclerosis.

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation.

Neuregulin-1 beta 1 is implicated in pathogenesis of multiple sclerosis.

Intracerebral haemorrhage: from clinical settings to animal models.

Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis.

Multimodal peripheral fluid biomarker analysis in clinically isolated syndrome and early multiple sclerosis.

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia.

Circadian disruption in mice through chronic jet lag-like conditions modulates molecular profiles of cancer in nucleus accumbens and prefrontal cortex.

Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor-initiating cells.

Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties.

Exercise rapidly alters proteomes in mice following spinal cord demyelination.

The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis.

Repurposing Domperidone in Secondary Progressive Multiple Sclerosis: A Simon 2-Stage Phase 2 Futility Trial.

The combination of deferoxamine and minocycline strengthens neuroprotective effect on acute intracerebral hemorrhage in rats.

Obesity in acute ischaemic stroke patients treated with intravenous thrombolysis therapy.

An X-ray for myelin.

Susceptibility weighted imaging detects prominent veins that precede or coincide with maximal motor disability in a model of multiple sclerosis: A pilot study.

Does chronic jet lag increase risk of cancer?

Hydroxychloroquine for Primary Progressive Multiple Sclerosis.

Studying the microglia response to oxidized phosphatidylcholine in primary mouse neuron culture and mouse spinal cord.

Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice.

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier.

MedXercise: a promising strategy to promote remyelination.

The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design.

Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis.

PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway.

Quantitative analysis of spinal cord neuropathology in experimental autoimmune encephalomyelitis.

B cells in central nervous system disease: diversity, locations and pathophysiology.

Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage.

Remyelination trial failures: Repercussions of ignoring neurorehabilitation and exercise in repair.

A Distinct Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology.

Modes of Brain Cell Death Following Intracerebral Hemorrhage.

Vildagliptin improves neurological function by inhibiting apoptosis and ferroptosis following intracerebral hemorrhage in mice.

Exercise training in multiple sclerosis.

Oxidative Stress Following Intracerebral Hemorrhage: From Molecular Mechanisms to Therapeutic Targets.

Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression.

Oxidized phospholipids as novel mediators of neurodegeneration.

Revisiting Minocycline in Intracerebral Hemorrhage: Mechanisms and Clinical Translation.

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination.

EMMPRIN Promotes the Expression of MMP-9 and Exacerbates Neurological Dysfunction in a Mouse Model of Intracerebral Hemorrhage.

Microglia in multiple sclerosis - pathogenesis and imaging.

Thermoregulatory dynamics reveal sex-specific inflammatory responses to experimental autoimmune encephalomyelitis in mice: Implications for multiple sclerosis-induced fatigue in females.

Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage Inhibiting Inflammation and Necroptosis.

Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage.

Neuroprotection by Ozanimod Following Intracerebral Hemorrhage in Mice.

Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.

Microglia in multiple sclerosis: Protectors turn destroyers.

Expression of antioxidant enzymes in lesions of multiple sclerosis and its models.

Neuroprotective Effects of Chlorogenic Acid in a Mouse Model of Intracerebral Hemorrhage Associated with Reduced Extracellular Matrix Metalloproteinase Inducer.

Microglia-T cell conversations in brain cancer progression.

Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage.

Aging microglia: old friends greet new enemies.

Detecting monocyte trafficking in an animal model of glioblastoma using R* and quantitative susceptibility mapping.

Bladder dysfunction in experimental autoimmune encephalomyelitis reflects clinical severity: A pilot study.

Serum neurofilament-light and glial fibrillary acidic protein levels in hydroxychloroquine-treated primary progressive multiple sclerosis.

Therapeutic strategies for intracerebral hemorrhage.

Multiple sclerosis progression: time for a new mechanism-driven framework.

The Important Role of Zinc in Neurological Diseases.

Single-Cell Spatial Analysis Identifies Regulators of Brain Tumor-Initiating Cells.

The Promise of Niacin in Neurology.

Single-cell and spatial RNA sequencing identify perturbators of microglial functions with aging.

Single Cell Analysis of High-Parameter Histology Images Using Histoflow Cytometry.

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages.

Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration.

Omarigliptin Protects the Integrity of the Blood-Brain Barrier After Intracerebral Hemorrhage in Mice.

Iron in multiple sclerosis - Neuropathology, immunology, and real-world considerations.

Distinct characteristics and severity of brain magnetic resonance imaging lesions in women and men with multiple sclerosis assessed using verified texture analysis measures.

Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage.

The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage.

Ion Channel Dysregulation Following Intracerebral Hemorrhage.

Tolerability of subcutaneous ofatumumab with long-term exposure in relapsing multiple sclerosis.

Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage.

Early life stress aggravates disease pathogenesis in mice with experimental autoimmune encephalomyelitis: Support for a two-hit hypothesis of multiple sclerosis etiology.

Prominent elevation of extracellular matrix molecules in intracerebral hemorrhage.

Crosstalk Between Matrix Metalloproteinases and Their Inducer EMMPRIN/CD147: a Promising Therapeutic Target for Intracerebral Hemorrhage.

Towards improving the prognosis of stroke through targeting the circadian clock system.

Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis.

Feasibility study to assess lesion repair in relapsing-remitting multiple sclerosis: A randomized controlled pilot clinical trial of domperidone add-on treatment.

Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice.

Biology of neurofibrosis with focus on multiple sclerosis.

Genetically predicted hypotaurine levels mediate the relationship between immune cells and intracerebral hemorrhage.

LXR agonism for CNS diseases: promises and challenges.

The cerebroprotection and prospects of FNDC5/irisin in stroke.

From progression to progress: The future of multiple sclerosis.

Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis.