Department of Medical Microbiology and Immunology,
Department of Pediatrics
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Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment.
Clinical immunology (Orlando, Fla.) Jan, 2002 | Pubmed ID: 11781063
Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain.
Journal of cell science Sep, 2002 | Pubmed ID: 12154072
RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site.
Molecular biology of the cell Feb, 2003 | Pubmed ID: 12589061
Dynamic imaging of cell-substrate contacts.
Methods in enzymology , 2003 | Pubmed ID: 12624919
Cytokine abnormalities in a patient with eosinophilic fasciitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Apr, 2003 | Pubmed ID: 12722970
Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.
Neuron May, 2003 | Pubmed ID: 12765611
Calpain-mediated proteolysis of talin regulates adhesion dynamics.
Nature cell biology Oct, 2004 | Pubmed ID: 15448700
Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study.
The Journal of pediatrics Dec, 2004 | Pubmed ID: 15580219
Cell polarization mechanisms during directed cell migration.
Nature cell biology Apr, 2005 | Pubmed ID: 15803131
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway.
Journal of leukocyte biology Jul, 2005 | Pubmed ID: 15845648
Calpain proteases in cell adhesion and motility.
International review of cytology , 2005 | Pubmed ID: 16125543
Regulating cell migration: calpains make the cut.
Journal of cell science Sep, 2005 | Pubmed ID: 16129881
Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells syndrome.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Oct, 2005 | Pubmed ID: 16279571
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration.
Molecular biology of the cell Jan, 2006 | Pubmed ID: 16280362
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.
The Journal of biological chemistry Apr, 2006 | Pubmed ID: 16436382
Characterization of a membrane-based gradient generator for use in cell-signaling studies.
Lab on a chip Mar, 2006 | Pubmed ID: 16511622
The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions.
Cell motility and the cytoskeleton Sep, 2006 | Pubmed ID: 16830345
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.
Journal of leukocyte biology Dec, 2006 | Pubmed ID: 16963624
Talin1 regulates TCR-mediated LFA-1 function.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2006 | Pubmed ID: 17114441
Asymmetric localization of calpain 2 during neutrophil chemotaxis.
Molecular biology of the cell Mar, 2007 | Pubmed ID: 17192410
Wound healing with electric potential.
The New England journal of medicine Jan, 2007 | Pubmed ID: 17229960
Analysis of neutrophil chemotaxis.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 17416985
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.
Experimental cell research Jul, 2007 | Pubmed ID: 17574549
Integrins in cell migration.
Methods in enzymology , 2007 | Pubmed ID: 17697879
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
Journal of cell science Oct, 2007 | Pubmed ID: 17881499
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis.
Molecular biology of the cell Dec, 2007 | Pubmed ID: 17928408
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.
Cell host & microbe Jul, 2007 | Pubmed ID: 18005715
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
The Journal of cell biology Mar, 2008 | Pubmed ID: 18332219
Adhesions ring: a structural comparison between podosomes and the immune synapse.
European journal of cell biology Sep, 2008 | Pubmed ID: 18343530
Analysis of neutrophil polarization and chemotaxis.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 18453114
Reverse leukocyte migration can be attractive or repulsive.
Trends in cell biology Jun, 2008 | Pubmed ID: 18468440
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
Molecular biology of the cell Aug, 2008 | Pubmed ID: 18480402
Natural killer T-cell autoreactivity leads to a specialized activation state.
Blood Nov, 2008 | Pubmed ID: 18779390
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment.
Lab on a chip Sep, 2008 | Pubmed ID: 18818806
Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype.
Arthritis and rheumatism Oct, 2008 | Pubmed ID: 18821685
The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.
Journal of cell science Nov, 2008 | Pubmed ID: 18840650
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.
Developmental dynamics : an official publication of the American Association of Anatomists Jan, 2009 | Pubmed ID: 19097072
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos.
Cellular microbiology May, 2009 | Pubmed ID: 19207728
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Feb, 2009 | Pubmed ID: 19230472
Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7.
PLoS pathogens Feb, 2009 | Pubmed ID: 19247439
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
The Journal of cell biology Apr, 2009 | Pubmed ID: 19364917
Selective and tunable gradient device for cell culture and chemotaxis study.
Lab on a chip Jun, 2009 | Pubmed ID: 19495465
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
Development (Cambridge, England) Aug, 2009 | Pubmed ID: 19570844
Characterization of zebrafish larval inflammatory macrophages.
Developmental and comparative immunology Nov, 2009 | Pubmed ID: 19619578
Innate immunity: wounds burst H2O2 signals to leukocytes.
Current biology : CB Jul, 2009 | Pubmed ID: 19640490
Neutrophil motility in vivo using zebrafish.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19763965
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19833735
Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst.
Molecular immunology Jan, 2010 | Pubmed ID: 19889458
Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19897731
Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation.
Molecular biology of the cell Jan, 2010 | Pubmed ID: 19910490
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).
The Journal of biological chemistry Apr, 2010 | Pubmed ID: 20150423
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.
Developmental cell Feb, 2010 | Pubmed ID: 20159593
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
PloS one , 2010 | Pubmed ID: 20479866
Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome.
Arthritis and rheumatism Aug, 2010 | Pubmed ID: 20506269
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.
Blood Oct, 2010 | Pubmed ID: 20592249
PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20855869
An arrayed high-content chemotaxis assay for patient diagnosis.
Integrative biology : quantitative biosciences from nano to macro Nov, 2010 | Pubmed ID: 20953490
Introduction to the mechanisms of directed cell migration themed issue.
Integrative biology : quantitative biosciences from nano to macro Nov, 2010 | Pubmed ID: 20957298
Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia.
The Journal of allergy and clinical immunology Feb, 2011 | Pubmed ID: 21167572
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish.
Journal of leukocyte biology May, 2011 | Pubmed ID: 21248150
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays.
Analytical chemistry Feb, 2011 | Pubmed ID: 21261280
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21270128
Hax1 regulates neutrophil adhesion and motility through RhoA.
The Journal of cell biology May, 2011 | Pubmed ID: 21518791
Imaging podosome dynamics and matrix degradation.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21748673
Integrins in cell migration.
Cold Spring Harbor perspectives in biology Sep, 2011 | Pubmed ID: 21885598
A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2011 | Pubmed ID: 21900181
Live imaging of LFA-1-dependent T-cell motility and stop signals.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 21909914
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.
Developmental cell Oct, 2011 | Pubmed ID: 22014524
Contact-dependent T cell activation and T cell stopping require talin1.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22075696
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.
Nature Dec, 2011 | Pubmed ID: 22101434
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.
Cellular microbiology Apr, 2012 | Pubmed ID: 22188170
Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.
Journal of cell science Mar, 2012 | Pubmed ID: 22303001
The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.
The Journal of biological chemistry Jul, 2012 | Pubmed ID: 22679023
Spatiotemporal regulation of Src and its substrates at invadosomes.
European journal of cell biology Nov-Dec, 2012 | Pubmed ID: 22823952
Neutrophil reverse migration becomes transparent with zebrafish.
Advances in hematology , 2012 | Pubmed ID: 22844288
Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays.
Blood Oct, 2012 | Pubmed ID: 22915642
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish.
Journal of cell science Nov, 2012 | Pubmed ID: 22946052
The role of microtubules in neutrophil polarity and migration in live zebrafish.
Journal of cell science Dec, 2012 | Pubmed ID: 22992461
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish.
The Journal of cell biology Oct, 2012 | Pubmed ID: 23045550
Innate immune response to Streptococcus iniae infection in zebrafish larvae.
Infection and immunity Jan, 2013 | Pubmed ID: 23090960
Leukocyte migration from a fish eye's view.
Journal of cell science Sep, 2012 | Pubmed ID: 23104739
Citrullination of fibronectin modulates synovial fibroblast behavior.
Arthritis research & therapy , 2012 | Pubmed ID: 23127210
Kit-On-A-Lid-Assays for accessible self-contained cell assays.
Lab on a chip Feb, 2013 | Pubmed ID: 23229806
ECM: chemoattraction but not adhesion.
Blood Feb, 2013 | Pubmed ID: 23449615
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.
Journal of leukocyte biology May, 2013 | Pubmed ID: 23475575
Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging.
Lab on a chip May, 2013 | Pubmed ID: 23503983
Rational design of a ligand-controlled protein conformational switch.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23569285
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.
PLoS pathogens , 2013 | Pubmed ID: 23592999
Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion.
Cytoskeleton (Hoboken, N.J.) Jul, 2013 | Pubmed ID: 23595955
Interstitial leukocyte migration in vivo.
Current opinion in cell biology Oct, 2013 | Pubmed ID: 23797028
The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.
Biochemical pharmacology Sep, 2013 | Pubmed ID: 23928188
Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation.
PeerJ , 2013 | Pubmed ID: 24010013
WRAMPing up calcium in migrating cells by localized ER transport.
Developmental cell Sep, 2013 | Pubmed ID: 24091010
Neutrophil migration: moving from zebrafish models to human autoimmunity.
Immunological reviews Nov, 2013 | Pubmed ID: 24117827
Heat shock modulates neutrophil motility in zebrafish.
PloS one , 2013 | Pubmed ID: 24367659
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
Blood Apr, 2014 | Pubmed ID: 24421327
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.
Arthritis & rheumatology (Hoboken, N.J.) Jun, 2014 | Pubmed ID: 24497204
Spinning disk confocal imaging of neutrophil migration in zebrafish.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24504955
Characterizing asthma from a drop of blood using neutrophil chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2014 | Pubmed ID: 24711384
Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology.
Arthritis care & research May, 2014 | Pubmed ID: 24756998
Inflammation and wound repair.
Seminars in immunology Aug, 2014 | Pubmed ID: 24853879
Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.
Eukaryotic cell Oct, 2014 | Pubmed ID: 24879123
Reply: To PMID 24497204.
Arthritis & rheumatology (Hoboken, N.J.) Sep, 2014 | Pubmed ID: 24891318
Editorial overview: cell adhesion and migration.
Current opinion in cell biology Oct, 2014 | Pubmed ID: 25179864
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
Science (New York, N.Y.) Sep, 2014 | Pubmed ID: 25213377
Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis.
Arthritis research & therapy , 2014 | Pubmed ID: 25280866
Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition.
PloS one , 2014 | Pubmed ID: 25372289
Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration.
The Journal of cell biology Dec, 2014 | Pubmed ID: 25488917
In vivo imaging and characterization of actin microridges.
PloS one , 2015 | Pubmed ID: 25629723
Neutrophils in host defense: new insights from zebrafish.
Journal of leukocyte biology Feb, 2015 | Pubmed ID: 25717145
Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.
The Journal of experimental medicine Apr, 2015 | Pubmed ID: 25870200
Matrix metalloproteinase 9 modulates collagen matrices and wound repair.
Development (Cambridge, England) Jun, 2015 | Pubmed ID: 26015541
Strategies from UW-Madison for rescuing biomedical research in the US.
eLife Jun, 2015 | Pubmed ID: 26122792
Neutrophils in pediatric autoimmune disease.
Current opinion in rheumatology Sep, 2015 | Pubmed ID: 26147757
Neutrophils, wounds, and cancer progression.
Developmental cell Jul, 2015 | Pubmed ID: 26218320
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D.
Biomedical microdevices Oct, 2015 | Pubmed ID: 26354879
Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish.
Cellular microbiology Apr, 2016 | Pubmed ID: 26468080
Neutrophils in the Tumor Microenvironment.
Trends in immunology Jan, 2016 | Pubmed ID: 26700397
Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.
The Journal of biological chemistry Jul, 2016 | Pubmed ID: 27129278
Neutrophil migration in infection and wound repair: going forward in reverse.
Nature reviews. Immunology 05, 2016 | Pubmed ID: 27231052
Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration.
Developmental cell Jul, 2016 | Pubmed ID: 27459068
A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells, and Neutrophils in the Establishment and Control of Sustained Fungemia.
Infection and immunity Oct, 2016 | Pubmed ID: 27481252
The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.
PLoS pathogens Sep, 2016 | Pubmed ID: 27622514
zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae.
Zebrafish Feb, 2017 | Pubmed ID: 27676647
Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station.
mSphere Sep-Oct, 2016 | Pubmed ID: 27830189
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2016 | Pubmed ID: 27837107
Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.
Cell reports May, 2017 | Pubmed ID: 28467895
Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.
Cell reports May, 2017 | Pubmed ID: 28538177
Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae.
Fungal genetics and biology : FG & B Aug, 2017 | Pubmed ID: 28559109
Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.
Cell reports Jun, 2017 | Pubmed ID: 28591586
Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection.
PloS one , 2017 | Pubmed ID: 28658259
Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues.
Journal of cell science Sep, 2017 | Pubmed ID: 28972134
Kayla Huemer*,1,2,
Jayne M. Squirrell*,3,
Robert Swader2,
Kirsten Pelkey2,
Danny C. LeBert4,
Anna Huttenlocher5,6,
Kevin W. Eliceiri1,2,3
1Department of Biomedical Engineering, University of Wisconsin-Madison,
2Morgridge Institute for Research, University of Wisconsin-Madison,
3Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison,
4Cellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison,
5Department of Medical Microbiology and Immunology, University of Wisconsin-Madison,
6Department of Pediatrics, University of Wisconsin-Madison
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