Anna Huttenlocher

Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment.

Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain.

RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site.

Dynamic imaging of cell-substrate contacts.

Cytokine abnormalities in a patient with eosinophilic fasciitis.

Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.

Calpain-mediated proteolysis of talin regulates adhesion dynamics.

Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study.

Cell polarization mechanisms during directed cell migration.

TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway.

Calpain proteases in cell adhesion and motility.

Regulating cell migration: calpains make the cut.

Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells syndrome.

Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration.

TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.

Characterization of a membrane-based gradient generator for use in cell-signaling studies.

The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions.

Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.

Talin1 regulates TCR-mediated LFA-1 function.

Asymmetric localization of calpain 2 during neutrophil chemotaxis.

Wound healing with electric potential.

Analysis of neutrophil chemotaxis.

RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.

Integrins in cell migration.

Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.

Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis.

Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

Adhesions ring: a structural comparison between podosomes and the immune synapse.

Analysis of neutrophil polarization and chemotaxis.

Reverse leukocyte migration can be attractive or repulsive.

The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.

Natural killer T-cell autoreactivity leads to a specialized activation state.

A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment.

Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype.

The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.

Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.

Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos.

Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin.

Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7.

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.

Selective and tunable gradient device for cell culture and chemotaxis study.

The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.

Characterization of zebrafish larval inflammatory macrophages.

Innate immunity: wounds burst H2O2 signals to leukocytes.

Neutrophil motility in vivo using zebrafish.

Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.

Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst.

Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.

Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation.

Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).

Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.

Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.

Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome.

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.

PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.

An arrayed high-content chemotaxis assay for patient diagnosis.

Introduction to the mechanisms of directed cell migration themed issue.

Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia.

Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish.

Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays.

Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.

Hax1 regulates neutrophil adhesion and motility through RhoA.

Imaging podosome dynamics and matrix degradation.

Integrins in cell migration.

A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.

Live imaging of LFA-1-dependent T-cell motility and stop signals.

Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.

Contact-dependent T cell activation and T cell stopping require talin1.

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.

Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.

Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.

The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.

Spatiotemporal regulation of Src and its substrates at invadosomes.

Neutrophil reverse migration becomes transparent with zebrafish.

Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays.

The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish.

The role of microtubules in neutrophil polarity and migration in live zebrafish.

Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish.

Innate immune response to Streptococcus iniae infection in zebrafish larvae.

Leukocyte migration from a fish eye's view.

Citrullination of fibronectin modulates synovial fibroblast behavior.

Kit-On-A-Lid-Assays for accessible self-contained cell assays.

ECM: chemoattraction but not adhesion.

Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.

Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging.

Rational design of a ligand-controlled protein conformational switch.

Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.

Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion.

Interstitial leukocyte migration in vivo.

The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.

Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation.

WRAMPing up calcium in migrating cells by localized ER transport.

Neutrophil migration: moving from zebrafish models to human autoimmunity.

Heat shock modulates neutrophil motility in zebrafish.

The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.

Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.

Spinning disk confocal imaging of neutrophil migration in zebrafish.

Characterizing asthma from a drop of blood using neutrophil chemotaxis.

Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology.

Inflammation and wound repair.

Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.

Reply: To PMID 24497204.

Editorial overview: cell adhesion and migration.

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis.

Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition.

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration.

In vivo imaging and characterization of actin microridges.

Neutrophils in host defense: new insights from zebrafish.

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.

Matrix metalloproteinase 9 modulates collagen matrices and wound repair.

Strategies from UW-Madison for rescuing biomedical research in the US.

Neutrophils in pediatric autoimmune disease.

Neutrophils, wounds, and cancer progression.

Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D.

Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish.

Neutrophils in the Tumor Microenvironment.

Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.

Neutrophil migration in infection and wound repair: going forward in reverse.

Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration.

A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells, and Neutrophils in the Establishment and Control of Sustained Fungemia.

The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.

zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae.

Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station.

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.

Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection.

Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues.