Yuji Mishina

Requirement of Bmpr1a for Müllerian duct regression during male sexual development.

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3.

Generation of Bmpr/Alk3 conditional knockout mice.

AF-2 knock-in mutation of estrogen receptor alpha: Cre-loxP excision of a PGK-neo cassette from the 3' UTR.

Genetic studies of MIS signalling in sexual development.

Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism.

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies.

BMP signaling is required locally to pattern the dorsal telencephalic midline.

Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis.

Function of bone morphogenetic protein signaling during mouse development.

Receptor knock-out and gene targeting. Generation of knock-out mice.

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage.

Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction.

Identification of the haematopoietic stem cell niche and control of the niche size.

Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected].

Genetic studies of the AMH/MIS signaling pathway for Müllerian duct regression.

Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.

BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.

BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling.

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.

BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.

Multiplex GPCR assay in reverse transfection cell microarrays.

Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells.

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.

Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord.

BMP receptor signaling is required for postnatal maintenance of articular cartilage.

Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity.

BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo.

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development.

Distinct functions for Bmp signaling in lip and palate fusion in mice.

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.

BMP signaling and early embryonic patterning.

Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein.

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus.

Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.

Optimized beta-galactosidase staining method for simultaneous detection of endogenous gene expression in early mouse embryos.

Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse.

Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2.

BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.

Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.

BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.

BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis.

BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.

The DVE changes distal epiblast fate from definitive endoderm to neurectoderm by antagonizing nodal signaling.

BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.

Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect.

BMPR1a signaling determines numbers of oligodendrocytes and calbindin-expressing interneurons in the cortex.

Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage.

BMP signalling inhibits premature neural differentiation in the mouse embryo.

Sox8 and Sertoli-cell function.

Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis.

Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor.

Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling.

BMP receptor ALK3 controls collecting system development.

Generation of a conditional null allele for Dmp1 in mouse.

Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.

Sox8 is a critical regulator of adult Sertoli cell function and male fertility.

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier.

SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis.

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

Generation of a conditional mutant allele for Tab1 in mouse.

Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.

TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

BMP type I receptor inhibition reduces heterotopic [corrected] ossification.

Bmp2 is required for cephalic neural tube closure in the mouse.

Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling.

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.

Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development.

Thienopyridine and cilostazol are safer for gastroduodenal mucosa than low-dose aspirin--second report of endoscopic evaluation.

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest.

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways.

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis.

Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice.

Prevalence of erosive esophagitis among Japanese patients taking low-dose aspirin.

Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo.

Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton.

Gastroduodenal mucosal injury in patients taking low-dose aspirin and the role of gastric mucoprotective drugs: possible effect of rebamipide.

Mechanisms of bone morphogenetic protein 2 (BMP2) stimulated inhibitor of DNA binding 3 (Id3) transcription.

BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea.

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.

Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells.

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.

New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.

Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.

Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice.

Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry.

Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators.

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.

Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

Potential contribution of neural crest cells to dental enamel formation.

Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.

Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.

A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.

Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds.

Identification and characterization of neural crest-derived cells in adult periodontal ligament of mice.

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.

TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.

Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice.

The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.

Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

Constitutively active ALK2 receptor mutants require type II receptor cooperation.

SOX8 regulates permeability of the blood-testes barrier that affects adult male fertility in the mouse.

Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos.

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.

BMP receptor 1A determines the cell fate of the postnatal growth plate.

Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell.

In situ hybridization methods for mouse whole mounts and tissue sections with and without additional β-galactosidase staining.

Neural crest cell signaling pathways critical to cranial bone development and pathology.

FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.

AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.

Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.

BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease.

Critical role of Bmpr1a in mandibular condyle growth.

Cranial neural crest cell contribution to craniofacial formation, pathology, and future directions in tissue engineering.

Targeting of ALK2, a Receptor for Bone Morphogenetic Proteins, Using the Cre/lox System to Enhance Osseous Regeneration by Adipose-Derived Stem Cells.

PDGF-AA promotes osteogenic differentiation and migration of mesenchymal stem cell by down-regulating PDGFRα and derepressing BMP-Smad1/5/8 signaling.

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.

Osterix-Cre transgene causes craniofacial bone development defect.

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse.

BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints.

Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis.

Abstract 89: Novel Targeting of the Alk-2 Receptor Using the Cre/lox System to Enhance Osseous Regeneration by Mesenchymal Stem Cells.

Abstract 148: use of bmp type I alk-3 knockout mice to develop novel treatment strategies for trauma-induced heterotopic ossification.

Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.

Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice.

Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis.

Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation.

Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition.

Generation and Identification of Genetically Modified Mice for BMP Receptors.

Phenotypic Analyses of Genetically Modified Mice for BMP Receptors.