John Disterhoft

Age-related biophysical alterations of hippocampal pyramidal neurons: implications for learning and memory.

Temporal discrimination learning in abstinent chronic alcoholics.

Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.

Single neurons in CA1 hippocampus encode trace interval duration during trace heart rate (fear) conditioning in rabbit.

Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit.

Watermaze learning enhances excitability of CA1 pyramidal neurons.

Lubeluzole and conditioned learning after cerebral ischemia.

Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals.

Functional magnetic resonance imaging in the awake rabbit: a system for stimulus presentation and response detection during eyeblink conditioning.

Conditional discrimination learning in patients with bilateral medial temporal lobe amnesia.

fMRI of the conscious rabbit during unilateral classical eyeblink conditioning reveals bilateral cerebellar activation.

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.

Galantamine facilitates acquisition of hippocampus-dependent trace eyeblink conditioning in aged rabbits.

Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation.

Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease.

A fiber optic-based system for behavioral eyeblink measurement in a MRI environment.

Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning.

Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons.

Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.

GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease.

Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning.

Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.

Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity.

Learning, aging and intrinsic neuronal plasticity.

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions.

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.

Cortical barrel lesions impair whisker-CS trace eyeblink conditioning.

Alterations in intrinsic neuronal excitability during normal aging.

Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.

Where is the trace in trace conditioning?

Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics.

Procedural memory system supports single cue trace eyeblink conditioning in medial temporal lobe amnesia.

Functional magnetic resonance imaging of delay and trace eyeblink conditioning in the primary visual cortex of the rabbit.

Neural substrates underlying human delay and trace eyeblink conditioning.

Evoking blinks with natural stimulation and detecting them with a noninvasive optical device: a simple, inexpensive method for use with freely moving animals.

Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons.

Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.

The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.

A novel method for precisely timed stimulation of mouse whiskers in a freely moving preparation: application for delivery of the conditioned stimulus in trace eyeblink conditioning.

Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A.

Blocking the BK channel impedes acquisition of trace eyeblink conditioning.

Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation.

The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning.

The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.

Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice.

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.

Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning.

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.

Caudate nucleus is critically involved in trace eyeblink conditioning.

Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.

Learning and aging related changes in intrinsic neuronal excitability.

The effects of aging in delay and trace human eyeblink conditioning.

Exploring prefrontal cortical memory mechanisms with eyeblink conditioning.

Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough.

Reevaluating hippocampus-dependent learning in FVB/N mice.

A MRI-compatible system for whisker stimulation.

Increasing SK2 channel activity impairs associative learning.

Infragranular barrel cortex activity is enhanced with learning.

Perirhinal and postrhinal, but not lateral entorhinal, cortices are essential for acquisition of trace eyeblink conditioning.

Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation.

Cellular mechanisms for altered learning in aging.

Learning increases intrinsic excitability of hippocampal interneurons.

Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons.

Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.

Surface L-type Ca2+ channel expression levels are increased in aged hippocampus.

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.

Functional reorganization of a prefrontal cortical network mediating consolidation of trace eyeblink conditioning.

Increased Excitability of Both Principal Neurons and Interneurons during Associative Learning.

Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2.

Age-related impairments on one hippocampal-dependent task predict impairments on a subsequent hippocampal-dependent task.

Robust hippocampal responsivity during retrieval of consolidated associative memory.

Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.

The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.

Hippocampectomy disrupts trace eye-blink conditioning in rabbits.

Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.

Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases.

Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation.

Forebrain-Cerebellar Interactions During Learning.

Intrinsic connectivity of neural networks in the awake rabbit.

Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit.

The Development of Rapastinel (Formerly GLYX-13); a rapid acting and long lasting antidepressant.