Department of Physiology
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Age-related biophysical alterations of hippocampal pyramidal neurons: implications for learning and memory.
Ageing research reviews Apr, 2002 | Pubmed ID: 12039438
Temporal discrimination learning in abstinent chronic alcoholics.
Alcoholism, clinical and experimental research Jun, 2002 | Pubmed ID: 12068248
Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2002 | Pubmed ID: 12177218
Single neurons in CA1 hippocampus encode trace interval duration during trace heart rate (fear) conditioning in rabbit.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2003 | Pubmed ID: 12598642
Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit.
Journal of neurophysiology Aug, 2003 | Pubmed ID: 12750412
Watermaze learning enhances excitability of CA1 pyramidal neurons.
Journal of neurophysiology Oct, 2003 | Pubmed ID: 12815013
Lubeluzole and conditioned learning after cerebral ischemia.
Experimental brain research Oct, 2003 | Pubmed ID: 12904938
Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals.
Neurobiology of learning and memory Nov, 2003 | Pubmed ID: 14521865
Functional magnetic resonance imaging in the awake rabbit: a system for stimulus presentation and response detection during eyeblink conditioning.
Journal of neuroscience methods Nov, 2003 | Pubmed ID: 14583403
Conditional discrimination learning in patients with bilateral medial temporal lobe amnesia.
Behavioral neuroscience Dec, 2003 | Pubmed ID: 14674839
fMRI of the conscious rabbit during unilateral classical eyeblink conditioning reveals bilateral cerebellar activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2003 | Pubmed ID: 14684877
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.
Neuron Jan, 2004 | Pubmed ID: 14715132
Galantamine facilitates acquisition of hippocampus-dependent trace eyeblink conditioning in aged rabbits.
Learning & memory (Cold Spring Harbor, N.Y.) Jan-Feb, 2004 | Pubmed ID: 14747524
Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation.
Journal of neurophysiology Oct, 2004 | Pubmed ID: 15190096
Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease.
Ageing research reviews Nov, 2004 | Pubmed ID: 15541708
A fiber optic-based system for behavioral eyeblink measurement in a MRI environment.
Journal of neuroscience methods Jan, 2005 | Pubmed ID: 15585291
Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning.
Neuropsychology Mar, 2005 | Pubmed ID: 15769200
Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons.
Learning & memory (Cold Spring Harbor, N.Y.) Mar-Apr, 2005 | Pubmed ID: 15805311
Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.
Learning & memory (Cold Spring Harbor, N.Y.) May-Jun, 2005 | Pubmed ID: 15897256
GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.
Neuropharmacology Dec, 2005 | Pubmed ID: 16051282
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
The European journal of neuroscience Jan, 2006 | Pubmed ID: 16420434
Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease.
Journal of physiology, Paris Mar-May, 2006 | Pubmed ID: 16458491
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning.
Learning & memory (Cold Spring Harbor, N.Y.) Mar-Apr, 2006 | Pubmed ID: 16585795
Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.
The European journal of neuroscience Apr, 2006 | Pubmed ID: 16630070
Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2006 | Pubmed ID: 16738249
Learning, aging and intrinsic neuronal plasticity.
Trends in neurosciences Oct, 2006 | Pubmed ID: 16942805
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2006 | Pubmed ID: 17021169
Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions.
The Journal of physiology Feb, 2007 | Pubmed ID: 17138601
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.
Neurobiology of disease Apr, 2007 | Pubmed ID: 17258906
Cortical barrel lesions impair whisker-CS trace eyeblink conditioning.
Learning & memory (Cold Spring Harbor, N.Y.) Jan-Feb, 2007 | Pubmed ID: 17272654
Alterations in intrinsic neuronal excitability during normal aging.
Aging cell Jun, 2007 | Pubmed ID: 17517042
Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.
Neurobiology of learning and memory Feb, 2008 | Pubmed ID: 17703960
Where is the trace in trace conditioning?
Trends in neurosciences Feb, 2008 | Pubmed ID: 18199490
Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics.
Neuropsychology Mar, 2008 | Pubmed ID: 18331162
Procedural memory system supports single cue trace eyeblink conditioning in medial temporal lobe amnesia.
Neuropsychology Mar, 2008 | Pubmed ID: 18331171
Functional magnetic resonance imaging of delay and trace eyeblink conditioning in the primary visual cortex of the rabbit.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2008 | Pubmed ID: 18463251
Neural substrates underlying human delay and trace eyeblink conditioning.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2008 | Pubmed ID: 18523017
Evoking blinks with natural stimulation and detecting them with a noninvasive optical device: a simple, inexpensive method for use with freely moving animals.
Journal of neuroscience methods Aug, 2008 | Pubmed ID: 18598716
Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons.
Neurobiology of aging May, 2010 | Pubmed ID: 18620783
Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
Journal of neurophysiology Oct, 2008 | Pubmed ID: 18715900
The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18799739
A novel method for precisely timed stimulation of mouse whiskers in a freely moving preparation: application for delivery of the conditioned stimulus in trace eyeblink conditioning.
Journal of neuroscience methods Mar, 2009 | Pubmed ID: 19041891
Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19164584
Blocking the BK channel impedes acquisition of trace eyeblink conditioning.
Learning & memory (Cold Spring Harbor, N.Y.) Feb, 2009 | Pubmed ID: 19181615
Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation.
Neurobiology of learning and memory Jul, 2009 | Pubmed ID: 19245842
The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2009 | Pubmed ID: 19369544
The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.
Neurobiology of aging Apr, 2011 | Pubmed ID: 19446371
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice.
Learning & memory (Cold Spring Harbor, N.Y.) Jun, 2009 | Pubmed ID: 19470651
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.
Nature neuroscience Aug, 2009 | Pubmed ID: 19620975
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19625617
Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning.
Journal of neurophysiology Nov, 2009 | Pubmed ID: 19726729
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.
PloS one , 2009 | Pubmed ID: 19841742
Caudate nucleus is critically involved in trace eyeblink conditioning.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2009 | Pubmed ID: 19923285
Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.
Neurobiology of aging Oct, 2011 | Pubmed ID: 20018411
Learning and aging related changes in intrinsic neuronal excitability.
Frontiers in aging neuroscience , 2010 | Pubmed ID: 20552042
The effects of aging in delay and trace human eyeblink conditioning.
Psychology and aging Sep, 2010 | Pubmed ID: 20677885
Exploring prefrontal cortical memory mechanisms with eyeblink conditioning.
Behavioral neuroscience Jun, 2011 | Pubmed ID: 21517143
Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough.
Developmental psychobiology Jul, 2011 | Pubmed ID: 21678397
Reevaluating hippocampus-dependent learning in FVB/N mice.
Behavioral neuroscience Dec, 2011 | Pubmed ID: 22122148
A MRI-compatible system for whisker stimulation.
Journal of neuroscience methods Apr, 2012 | Pubmed ID: 22322316
Increasing SK2 channel activity impairs associative learning.
Journal of neurophysiology Aug, 2012 | Pubmed ID: 22552186
Infragranular barrel cortex activity is enhanced with learning.
Journal of neurophysiology Sep, 2012 | Pubmed ID: 22696544
Perirhinal and postrhinal, but not lateral entorhinal, cortices are essential for acquisition of trace eyeblink conditioning.
Learning & memory (Cold Spring Harbor, N.Y.) , 2013 | Pubmed ID: 23322556
Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2013 | Pubmed ID: 23407942
Cellular mechanisms for altered learning in aging.
Future neurology Jan, 2010 | Pubmed ID: 23525658
Learning increases intrinsic excitability of hippocampal interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2013 | Pubmed ID: 23536065
Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2013 | Pubmed ID: 23637181
Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.
Human brain mapping Apr, 2014 | Pubmed ID: 23674498
Surface L-type Ca2+ channel expression levels are increased in aged hippocampus.
Aging cell Feb, 2014 | Pubmed ID: 24033980
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.
Expert opinion on investigational drugs Feb, 2014 | Pubmed ID: 24251380
Functional reorganization of a prefrontal cortical network mediating consolidation of trace eyeblink conditioning.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2014 | Pubmed ID: 24453332
Increased Excitability of Both Principal Neurons and Interneurons during Associative Learning.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Aug, 2015 | Pubmed ID: 24946769
Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25246588
Age-related impairments on one hippocampal-dependent task predict impairments on a subsequent hippocampal-dependent task.
Behavioral neuroscience Dec, 2014 | Pubmed ID: 25420127
Robust hippocampal responsivity during retrieval of consolidated associative memory.
Hippocampus May, 2015 | Pubmed ID: 25515308
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.
Behavioural brain research Nov, 2015 | Pubmed ID: 26210936
The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.
Behavioral neuroscience Aug, 2015 | Pubmed ID: 26214216
Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
Behavioral neuroscience Aug, 2015 | Pubmed ID: 26214217
Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2015 | Pubmed ID: 26400949
Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases.
Frontiers in psychiatry , 2015 | Pubmed ID: 26500564
Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation.
NeuroImage Feb, 2016 | Pubmed ID: 26589332
Forebrain-Cerebellar Interactions During Learning.
Cellscience Oct, 2006 | Pubmed ID: 26617664
Intrinsic connectivity of neural networks in the awake rabbit.
NeuroImage Apr, 2016 | Pubmed ID: 26774609
Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit.
Learning & memory (Cold Spring Harbor, N.Y.) Apr, 2016 | Pubmed ID: 26980784
The Development of Rapastinel (Formerly GLYX-13); a rapid acting and long lasting antidepressant.
Current neuropharmacology Mar, 2016 | Pubmed ID: 26997507
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