Dieter Egli

Breaking ground on translational stem cell research.

Recipient cell nuclear factors are required for reprogramming by nuclear transfer.

The New York Stem Cell Foundation: Fifth Annual Translational Stem Cell Research Conference.

Reprogramming within hours following nuclear transfer into mouse but not human zygotes.

Human oocytes reprogram somatic cells to a pluripotent state.

Impracticality of egg donor recruitment in the absence of compensation.

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

Long-term safety and efficacy of human induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa.

Mouse ooplasm confers context-specific reprogramming capacity.

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.

Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting.

Tying replication to cell identity.

iPSC-derived β cells model diabetes due to glucokinase deficiency.

Connecting the cell cycle with cellular identity.

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

Harnessing the stem cell potential: the path to prevent mitochondrial disease.

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects.

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures.

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors.

Differentiation of hypothalamic-like neurons from human pluripotent stem cells.

Toward beta cell replacement for diabetes.

Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.

Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.

An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.

Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.

Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.

A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification.

The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.

Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.

In vivo construction of transgenes in Drosophila.

Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance.

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes.

CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory.

Mediators of reprogramming: transcription factors and transitions through mitosis.

Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila.

Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity.

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.

Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.

Reprogramming after chromosome transfer into mouse blastomeres.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes?

From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer?

Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest.

Attitudes toward prevention of mtDNA-related diseases through oocyte mitochondrial replacement therapy.

Derivation and differentiation of haploid human embryonic stem cells.

Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.

Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells.

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq.

Identification and propagation of haploid human pluripotent stem cells.

Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.

Inconsistency in 'three-parent' IVF study.

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Genome Transfer Prevents Fragmentation and Restores Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes.

Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.

Tying genetic stability to cell identity.

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

ILDR2 has a negligible role in hepatic steatosis.

Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.

Identification and Analysis of Islet Antigen-Specific CD8 T Cells with T Cell Libraries.

Inter-homologue repair in fertilized human eggs?

Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells.

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus.

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.

NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data.

Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction.

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant.

Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells.

Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.

Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice.

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.

How Safe Are Universal Pluripotent Stem Cells?

Efficient SNP editing in haploid human pluripotent stem cells.

Lessons Learned from Somatic Cell Nuclear Transfer.

Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication.

Detection of base analogs incorporated during DNA replication by nanopore sequencing.

How Safe Are Universal Pluripotent Stem Cells?

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos.

Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size.

Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.

Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice.

The genetic architecture of DNA replication timing in human pluripotent stem cells.

Delayed DNA replication in haploid human embryonic stem cells.

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.

Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.

Replication stress impairs chromosome segregation and preimplantation development in human embryos.

Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency.

ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.

Replication stress in mammalian embryo development, differentiation, and reprogramming.

Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells.

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity.

Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells.

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.

Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity.