Kevin D. Costa

Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues.

Biomedical model fitting and error analysis.

Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells.

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.

Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.

Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.

Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine.

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.

Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes.

An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease.

An update on the etiology of abdominal aortic aneurysms: implications for future diagnostic testing.

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression.

Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy.

Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.

Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future?

Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome.

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents.

Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension.

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.

Coronary capillary blood flow in a rat model of congestive heart failure.

Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension.

Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling.

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility.

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.

Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments.

An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.

Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies.

Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.

Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.

Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues.

Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients.

High-resolution integrated piezoresistive sensors for microfluidic monitoring.

Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.

Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium.

Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.

Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members.

Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms.

Computational design of custom therapeutic cells to correct failing human cardiomyocytes.

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues.