Cardiovascular Research Center,
Cardiovascular Research Institute
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Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues.
Biomaterials Mar, 2016 | Pubmed ID: 26826618
Biomedical model fitting and error analysis.
Science signaling Sep, 2011 | Pubmed ID: 21954296
Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells.
Tissue engineering. Part A Jul, 2012 | Pubmed ID: 22500611
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.
Chemical communications (Cambridge, England) Oct, 2013 | Pubmed ID: 23877789
Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2013 | Pubmed ID: 24065831
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2014 | Pubmed ID: 24174427
Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
The Journal of clinical investigation Mar, 2014 | Pubmed ID: 24531548
Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine.
Circulation. Heart failure Jan, 2015 | Pubmed ID: 25342737
Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.
Circulation. Arrhythmia and electrophysiology Feb, 2015 | Pubmed ID: 25504561
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes.
Stem cell research & therapy Oct, 2014 | Pubmed ID: 25688759
An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease.
Surgical technology international May, 2015 | Pubmed ID: 26055010
An update on the etiology of abdominal aortic aneurysms: implications for future diagnostic testing.
Expert review of cardiovascular therapy Oct, 2015 | Pubmed ID: 26401919
Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2016 | Pubmed ID: 26471463
Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy.
PloS one , 2016 | Pubmed ID: 26784941
Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2016 | Pubmed ID: 26791211
Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future?
Journal of the American College of Cardiology Mar, 2016 | Pubmed ID: 26940930
Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome.
Annals of biomedical engineering Oct, 2016 | Pubmed ID: 27090893
Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.
European heart journal Nov, 2016 | Pubmed ID: 27450564
Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.
PLoS computational biology Jul, 2016 | Pubmed ID: 27454812
Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27910047
Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension.
Cardiovascular research Feb, 2017 | Pubmed ID: 28003268
Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.
Circulation research Aug, 2017 | Pubmed ID: 28642329
CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.
Stem cell research 08, 2017 | Pubmed ID: 28711757
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.
Stem cell reports Nov, 2017 | Pubmed ID: 29033305
Coronary capillary blood flow in a rat model of congestive heart failure.
Journal of applied physiology (Bethesda, Md. : 1985) Mar, 2018 | Pubmed ID: 29051335
Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2017 | Pubmed ID: 29169155
Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling.
Circulation research Jan, 2018 | Pubmed ID: 29301848
Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility.
Circulation research 03, 2018 | Pubmed ID: 29449318
Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.
Biomaterials May, 2018 | Pubmed ID: 29459321
Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.
Journal of molecular and cellular cardiology Jun, 2018 | Pubmed ID: 29752948
Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments.
Biophysical journal Jun, 2018 | Pubmed ID: 29874620
An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29987808
Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29987817
Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.
Clinical pharmacology and therapeutics Aug, 2019 | Pubmed ID: 30723889
Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.
Scientific reports May, 2019 | Pubmed ID: 31097748
3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.
Additive manufacturing Oct, 2018 | Pubmed ID: 31106119
Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.
American journal of physiology. Heart and circulatory physiology Nov, 2019 | Pubmed ID: 31347915
Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues.
Stem cell research & therapy Dec, 2019 | Pubmed ID: 31801634
Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients.
Frontiers in physiology , 2020 | Pubmed ID: 32226389
High-resolution integrated piezoresistive sensors for microfluidic monitoring.
Lab on a chip Jan, 2021 | Pubmed ID: 33300516
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.
Journal of molecular and cellular cardiology Apr, 2021 | Pubmed ID: 33373642
Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium.
Frontiers in physiology , 2021 | Pubmed ID: 35046835
Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.
Cardiovascular research Dec, 2022 | Pubmed ID: 35191471
Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members.
Stem cell research Apr, 2022 | Pubmed ID: 35247838
Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms.
Hypertension (Dallas, Tex. : 1979) Aug, 2022 | Pubmed ID: 35766034
Computational design of custom therapeutic cells to correct failing human cardiomyocytes.
Frontiers in systems biology , 2023 | Pubmed ID: 36743445
Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues.
iScience Apr, 2023 | Pubmed ID: 36950112