Hans-Christoph Pape

When should we operate on major fractures in patients with severe head injuries?

Standardized outcome evaluation after blunt multiple injuries by scoring systems: a clinical follow-up investigation 2 years after injury.

The timing of fracture treatment in polytrauma patients: relevance of damage control orthopedic surgery.

The effect of dehydroepiandrosterone on hemorrhage-induced suppression of cellular immune function.

A modified method to culture human osteoblasts from bone tissue specimens using fibrin glue.

Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery.

Effects of intramedullary femoral fracture fixation: what is the impact of experimental studies in regards to the clinical knowledge?

Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression.

Damage control orthopedics: a case report.

Dehydroepiandrosterone (DHEA) modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture.

Upper sympathetic trunk lesion after video-assisted fracture stabilization of the thoracic spine: a case report.

Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma.

Effects of cardiac contusion in isolated perfused rat hearts.

The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model.

Hemorrhage in pelvic fracture: who needs angiography?

Functional outcome following scapulothoracic dissociation.

Improved comfort in lower limb lengthening with the intramedullary skeletal kinetic distractor. Principles and preliminary clinical experiences.

Pathophysiologic changes and effects of hypothermia on outcome in elective surgery and trauma patients.

Combination of femoral fracture treatment and corrective osteotomy in a child with osteogenesis imperfecta.

Total hip arthroplasty in young patients using the thrust plate prosthesis: clinical and radiological results.

Damage control: extremities.

L-selectin shows time and gender dependency in association with MODS.

Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries.

Does traumatic brain injury result in accelerated fracture healing?

The multiply injured child.

Improvements in passive car safety led to decreased injury severity--a comparison between the 1970s and 1990s.

Secondary effects of femoral instrumentation on pulmonary physiology in a standardised sheep model: what is the effect of lung contusion and reaming?

Alterations in the systemic inflammatory response after early total care and damage control procedures for femoral shaft fracture in severely injured patients.

The current status of road user injuries among the elderly in Germany: a medical and technical accident analysis.

Role of adhesion molecule ICAM in the pathogenesis of polymicrobial sepsis.

Damage control orthopaedics: evolving concepts in the treatment of patients who have sustained orthopaedic trauma.

Implant retention and removal after internal fixation of the symphysis pubis.

Limb lengthening with the Intramedullary Skeletal Kinetic Distractor (ISKD).

Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

Timing of fixation of major fractures in blunt polytrauma: role of conventional indicators in clinical decision making.

Reamed femoral nailing in sheep: does irrigation and aspiration of intramedullary contents alter the systemic response?

Genetic predisposition for a compromised immune system after multiple trauma.

Staged management and outcome of combined pelvic and liver trauma. An international experience of the deadly duo.

Which AIS based scoring system is the best predictor of outcome in orthopaedic blunt trauma patients?

Impact of hypothermia on the immunologic response after trauma and elective surgery.

Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?

Confusion regarding method of patient selection.

Leukocyte-endothelial interactions via ICAM-1 are detrimental in polymicrobial sepsis.

The risk of local infective complications after damage control procedures for femoral shaft fracture.

Immediate fracture fixation--which method? Comments on the John Border Memorial Lecture, Ottawa, 2005.

Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.

Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage.

Fat embolism and IM nailing.

Fat embolism: special situations bilateral femoral fractures and pathologic femoral fractures.

Experimental background--review of animal studies.

Fat embolism: the reaming controversy.

Safety and efficacy of vena cava filters in trauma patients.

Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage.

Influence of sex and age on mods and cytokines after multiple injuries.

Application of clinical proteomics in diagnosis and management of trauma patients.

Timing and duration of the initial pelvic stabilization after multiple trauma in patients from the German trauma registry: is there an influence on outcome?

Long term results of compartment syndrome of the lower limb in polytraumatised patients.

Association of IL-8-251A/T polymorphism with incidence of Acute Respiratory Distress Syndrome (ARDS) and IL-8 synthesis after multiple trauma.

Pelvic stabilization. Prehospital management of traumatic pelvic injuries.

FTY720 improves survival after transient ischemia and reperfusion of the hind limbs.

Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients).

Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis.

Trauma and immune reactivity: too much, or too little immune response?

Assessment of the clinical course with inflammatory parameters.

Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage.

Femoral nailing-related coagulopathy determined by first-hit magnitude: an animal study.

Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions.

Growth factor release following femoral nailing.

Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response.

External adjuncts to enhance fracture healing: what is the role of ultrasound?

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.

MRI is unnecessary to clear the cervical spine in obtunded/comatose trauma patients: the four-year experience of a level I trauma center.

Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: damage control orthopedic surgery.

Use of the 'reamer irrigator aspirator' system for non-infected tibial non-union after failed iliac crest grafting.

Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture.

The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture.

Animal models for trauma research: what are the options?

Missed injuries in trauma patients: A literature review.

Correlation between IL-6 levels and the systemic inflammatory response score: can an IL-6 cutoff predict a SIRS state?

Case report: The prone reduction of a sacroiliac disruption with a pelvic C-clamp.

IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock.

High-energy foot and ankle trauma: principles for formulating an individualized care plan.

History of open wound and fracture treatment.

Current thought regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam.

Exercise induced compartment syndrome of the pectoralis major/deltoid in a professional tree climber.

Systemic inflammatory response after extremity or truncal fracture operations.

30 years of polytrauma care: An analysis of the change in strategies and results of 4849 cases treated at a single institution.

Insulin therapy induces changes in the inflammatory response in a murine 2-hit model.

Restricted duty hours for surgeons and impact on residents quality of life, education, and patient care: a literature review.

Early diagnosis of tibial compartment syndrome: continuous pressure measurement or not?

Introduction: Biology and new technical trends in intramedullary nailing of the femur.

Intraoperative reduction techniques for difficult femoral fractures.

Patterns of mortality and causes of death in polytrauma patients--has anything changed?

Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study.

Reduction in mortality of severely injured patients in Germany.

Timing of fracture fixation in multitrauma patients: the role of early total care and damage control surgery.

Current theories on the pathophysiology of multiple organ failure after trauma.

Risk of symptomatic heterotopic ossification following plate osteosynthesis in multiple trauma patients: an analysis in a level-1 trauma centre.

Complex extremity fractures following high energy injuries: the limited value of existing classifications and a proposal for a treatment-guide.

Clinical re-examination 10 or more years after polytrauma: is there a gender related difference?

Technical tricks when using the reamer irrigator aspirator technique for autologous bone graft harvesting.

Peer teaching: a randomised controlled trial using student-teachers to teach musculoskeletal ultrasound.

Autologous bone graft: properties and techniques.

Predictors of late clinical outcome following orthopedic injuries after multiple trauma.

A civilian perspective on ballistic trauma and gunshot injuries.

Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock.

The timing of definitive fixation for major fractures in polytrauma--a matched-pair comparison between a US and European level I centres: analysis of current fracture management practice in polytrauma.

Health-related quality of life in patients with multiple injuries and traumatic brain injury 10+ years postinjury.

Pattern of release and relationship between HMGB-1 and IL-6 following blunt trauma.

RIA: The journey just started but what the future holds?

The biology of intramedullary reaming.

Measuring depression and PTSD after trauma: common scales and checklists.

Scoring systems for outcome after knee injuries.

Flexible fixation with locking plates.

Effects of near cortical slotted holes in locking plate constructs.

Models of lower extremity damage in mice: time course of organ damage and immune response.

Head injury in polytrauma-Is there an effect on outcome more than 10 years after the injury?

Periprosthetic fractures: epidemiology and future projections.

Upper extremity periarticular fractures: when should they be fixed and when should they be replaced?

Socio-economic outcome after blunt orthopaedic trauma: Implications on injury prevention.

Impact of Isolated Acetabular and Lower Extremity Fractures on Long-Term Outcome.

Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation.

The role of stem cells in fracture healing and nonunion.

Effects of pelvic volume changes on retroperitoneal and intra-abdominal pressure in the injured pelvic ring: a cadaveric model.

Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective.

Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major alterations of the systemic inflammatory response.

Knowledge transfer of spinal manipulation skills by student-teachers: a randomised controlled trial.

Is Helical Blade Nailing Superior to Locked Minimally Invasive Plating in Unstable Pertrochanteric Fractures?