Dominique Ardail

Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2).

Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing.

The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases.

Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.

Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting.

Plasma BNP and NT-proBNP assays by automated immunoanalyzers: analytical and clinical study.

Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering.

Differential regulation of cell death in head and neck cell carcinoma through alteration of cholesterol levels in lipid rafts microdomains.

Diversity and complexity of ceramide generation after exposure of jurkat leukemia cells to irradiation.

Growth hormone internalization in mitochondria decreases respiratory chain activity.

Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells.

Targeting a cornerstone of radiation resistance: cancer stem cell.

Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation.

Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation.

Radiation-enhanced cell migration/invasion process: a review.

[Cancer stem cells: Radiotherapeutic features and therapeutic targets].

[Radiosensitivity and/or radioresistance of head and neck cancers: Biological angle].

Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives.

Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC.

Carbon ion irradiation withstands cancer stem cells' migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC).

Preclinical models in HNSCC: A comprehensive review.

Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect.

Dual "mAb" HER family blockade in head and neck cancer human cell lines combined with photon therapy.