James D. Orth

The large GTPase dynamin regulates actin comet formation and movement in living cells.

Dynamin at the actin-membrane interface.

Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis.

A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.

Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.

Foot and mouth: podosomes, invadopodia and circular dorsal ruffles.

Caveolin-1 interacts directly with dynamin-2.

Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport.

A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization.

Get off my back! Rapid receptor internalization through circular dorsal ruffles.

Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.

Cell death when the SAC is out of commission.

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.

Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.

In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.

Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.