James D. Orth
Department of Molecular,
Cellular,
and Developmental Biology,
Department of Molecular, Cellular, and Developmental Biology
University of Colorado, Boulder
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The large GTPase dynamin regulates actin comet formation and movement in living cells.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2002 | Pubmed ID: 11782546
Dynamin at the actin-membrane interface.
Current opinion in cell biology Feb, 2003 | Pubmed ID: 12517701
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis.
Molecular and cellular biology Mar, 2003 | Pubmed ID: 12612086
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.
Molecular biology of the cell Mar, 2003 | Pubmed ID: 12631725
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Infection and immunity May, 2004 | Pubmed ID: 15102814
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles.
Nature reviews. Molecular cell biology Aug, 2004 | Pubmed ID: 15366708
Caveolin-1 interacts directly with dynamin-2.
Journal of molecular biology Apr, 2005 | Pubmed ID: 15811383
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport.
Nature cell biology May, 2005 | Pubmed ID: 15821732
A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization.
Cancer research Apr, 2006 | Pubmed ID: 16585185
Get off my back! Rapid receptor internalization through circular dorsal ruffles.
Cancer research Dec, 2006 | Pubmed ID: 17145849
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.
Cancer research May, 2008 | Pubmed ID: 18451153
Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.
Molecular cancer therapeutics Nov, 2008 | Pubmed ID: 18974392
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.
Cancer cell Oct, 2009 | Pubmed ID: 19800579
An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.
PloS one , 2009 | Pubmed ID: 19802393
Cell death when the SAC is out of commission.
Cell cycle (Georgetown, Tex.) Jun, 2010 | Pubmed ID: 20559025
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.
Cancer research Jul, 2011 | Pubmed ID: 21712408
Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.
Cancer letters Nov, 2011 | Pubmed ID: 21782324
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
Molecular biology of the cell Feb, 2012 | Pubmed ID: 22171325
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.
Science translational medicine Nov, 2014 | Pubmed ID: 25378644
In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.
Nature methods Jun, 2015 | Pubmed ID: 25867850
Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.
Scientific reports , 2015 | Pubmed ID: 26399741
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