Laboratory of Lymphocyte Biology
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Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity.
Cell Apr, 2002 | Pubmed ID: 11983151
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.
The Journal of experimental medicine May, 2002 | Pubmed ID: 11994424
A modified digestion-circularization PCR (DC-PCR) approach to detect hypermutation-associated DNA double-strand breaks.
Annals of the New York Academy of Sciences Apr, 2003 | Pubmed ID: 12727632
AID mediates hypermutation by deaminating single stranded DNA.
The Journal of experimental medicine May, 2003 | Pubmed ID: 12756266
V(D)J recombination and the evolution of the adaptive immune system.
PLoS biology Oct, 2003 | Pubmed ID: 14551913
The regulation of somatic hypermutation.
Current opinion in immunology Apr, 2004 | Pubmed ID: 15023419
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
Molecular and cellular biology Jun, 2006 | Pubmed ID: 16705187
A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus.
Immunity Jun, 2006 | Pubmed ID: 16782033
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
The Journal of experimental medicine Feb, 2007 | Pubmed ID: 17242162
Regulation of AID expression in the immune response.
The Journal of experimental medicine May, 2007 | Pubmed ID: 17452520
An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17483465
Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection.
Advances in immunology , 2007 | Pubmed ID: 17560276
Immunoglobulin somatic hypermutation.
Annual review of genetics , 2007 | Pubmed ID: 17576170
A mammalian microRNA expression atlas based on small RNA library sequencing.
Cell Jun, 2007 | Pubmed ID: 17604727
C to U editing at position 32 of the anticodon loop precedes tRNA 5' leader removal in trypanosomatids.
Nucleic acids research , 2007 | Pubmed ID: 17916576
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.
Immunity May, 2008 | Pubmed ID: 18450484
Shhh! Silencing by microRNA-155.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences Mar, 2009 | Pubmed ID: 19008191
A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei.
Nature May, 2009 | Pubmed ID: 19369939
A coming-of-age story: activation-induced cytidine deaminase turns 10.
Nature immunology Nov, 2009 | Pubmed ID: 19841648
Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.
The Journal of experimental medicine Nov, 2009 | Pubmed ID: 19887393
MicroRNAs of the immune system: roles in inflammation and cancer.
Annals of the New York Academy of Sciences Jan, 2010 | Pubmed ID: 20146715
Diverse functions for DNA and RNA editing in the immune system.
RNA biology Mar-Apr, 2010 | Pubmed ID: 20220309
Long noncoding RNAs: implications for antigen receptor diversification.
Advances in immunology , 2009 | Pubmed ID: 20457115
Using T. brucei as a biological epitope-display platform to elicit specific antibody responses.
Journal of immunological methods Oct, 2010 | Pubmed ID: 20800596
Cytidine deaminases: AIDing DNA demethylation?
Genes & development Oct, 2010 | Pubmed ID: 20889711
A role for autophagic protein beclin 1 early in lymphocyte development.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2011 | Pubmed ID: 21239722
Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs.
Nature structural & molecular biology Feb, 2011 | Pubmed ID: 21258325
MicroRNA control of lymphocyte differentiation and function.
Current opinion in immunology Jun, 2011 | Pubmed ID: 21353514
Identifying mRNA editing deaminase targets by RNA-Seq.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21370044
A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21507956
The C-terminal end of the Trypanosoma brucei editing deaminase plays a critical role in tRNA binding.
RNA (New York, N.Y.) Jul, 2011 | Pubmed ID: 21602302
Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.
PLoS pathogens , 2012 | Pubmed ID: 22952449
Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2013 | Pubmed ID: 23277564
A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells.
Nature immunology Jul, 2013 | Pubmed ID: 23708250
You break it, you fix it: functions for AID downstream of deamination.
Nature immunology Nov, 2013 | Pubmed ID: 24145783
The in vivo dynamics of antigenic variation in Trypanosoma brucei.
Science (New York, N.Y.) Mar, 2015 | Pubmed ID: 25814582
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
Cell reports Sep, 2015 | Pubmed ID: 26365193
A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.
Results and problems in cell differentiation , 2015 | Pubmed ID: 26537376
Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.
PLoS biology Dec, 2015 | Pubmed ID: 26646171
Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei.
PLoS genetics Jan, 2016 | Pubmed ID: 26796638
Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS.
Frontiers in immunology , 2015 | Pubmed ID: 26834738
Pseudouridylation meets next-generation sequencing.
Methods (San Diego, Calif.) Sep, 2016 | Pubmed ID: 26968262
Vesicles as Vehicles for Virulence.
Trends in parasitology Jun, 2016 | Pubmed ID: 27006155
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive.
PLoS genetics May, 2016 | Pubmed ID: 27149665
The VEXing problem of monoallelic expression in the African trypanosome.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2016 | Pubmed ID: 27317742
RNA editing generates cellular subsets with diverse sequence within populations.
Nature communications , 2016 | Pubmed ID: 27418407
Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.
PLoS pathogens Sep, 2016 | Pubmed ID: 27583379
RNA Editing Dynamically Rewrites the Cancer Code.
Trends in cancer Dec, 2015 | Pubmed ID: 27695712
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