Department of Biomedical Sciences,
Faculty of Medicine and Health Sciences,
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences
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Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III.
The Biochemical journal Jul, 2002 | Pubmed ID: 11931634
Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2003 | Pubmed ID: 12716941
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury.
Journal of neurochemistry Jan, 2004 | Pubmed ID: 14690533
Protective role of metallothioneins in the injured mammalian brain.
Reviews in the neurosciences , 2004 | Pubmed ID: 15357139
Spinal cord tissue affects ensheathing cell proliferation and apoptosis.
Neuroreport May, 2005 | Pubmed ID: 15858416
Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro.
Experimental neurology Jun, 2005 | Pubmed ID: 15869950
Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy.
Journal of neurotrauma Oct, 2005 | Pubmed ID: 16238485
Metallothioneins I and II: neuroprotective significance during CNS pathology.
The international journal of biochemistry & cell biology , 2007 | Pubmed ID: 17097331
Identification and characterization of a population of motile neurons in long-term cortical culture.
Cell motility and the cytoskeleton Apr, 2007 | Pubmed ID: 17245771
Acute reactive and regenerative changes in mature cortical axons following injury.
Neuroreport Feb, 2007 | Pubmed ID: 17314672
Metallothionein-IIA promotes neurite growth via the megalin receptor.
Experimental brain research Nov, 2007 | Pubmed ID: 17634932
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury.
The Journal of biological chemistry May, 2008 | Pubmed ID: 18334482
Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.
Journal of neurotrauma May, 2009 | Pubmed ID: 19416018
Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.
Journal of neurochemistry Sep, 2009 | Pubmed ID: 19619132
The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology Apr, 2010 | Pubmed ID: 20354655
Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain.
The FEBS journal Jul, 2010 | Pubmed ID: 20561053
Prolonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis.
Molecular neurodegeneration Aug, 2010 | Pubmed ID: 20704753
The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.
PloS one Aug, 2010 | Pubmed ID: 20711450
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes.
Molecular and cellular neurosciences Jan, 2011 | Pubmed ID: 20840869
Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration.
PloS one Apr, 2011 | Pubmed ID: 21556141
Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro.
Journal of cellular and molecular medicine Apr, 2012 | Pubmed ID: 21711447
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Oct, 2011 | Pubmed ID: 21779915
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy.
Cellular and molecular life sciences : CMLS Mar, 2012 | Pubmed ID: 21833580
Recent rodent models for Alzheimer's disease: clinical implications and basic research.
Journal of neural transmission (Vienna, Austria : 1996) Feb, 2012 | Pubmed ID: 22086139
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice.
Journal of neuroinflammation Dec, 2011 | Pubmed ID: 22152221
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.
PloS one , 2012 | Pubmed ID: 22363575
Redox-active Cu(II)-Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner.
Experimental neurology Oct, 2012 | Pubmed ID: 22691462
Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice.
Histology and histopathology 11, 2012 | Pubmed ID: 23018245
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.
Journal of neuroinflammation Mar, 2014 | Pubmed ID: 24655927
Editorial: The molecular pathology of cognitive decline: focus on metals.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 26136683
The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia.
Frontiers in cellular neuroscience , 2015 | Pubmed ID: 26578880
Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation.
Frontiers in cellular neuroscience , 2015 | Pubmed ID: 26778958
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
Nature communications Apr, 2016 | Pubmed ID: 27080313
Ultrastructural Mapping of the Zebrafish Gastrointestinal System as a Basis for Experimental Drug Studies.
BioMed research international , 2016 | Pubmed ID: 27340669
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