Roger S. Chung

Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III.

Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury.

Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury.

Protective role of metallothioneins in the injured mammalian brain.

Spinal cord tissue affects ensheathing cell proliferation and apoptosis.

Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro.

Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy.

Metallothioneins I and II: neuroprotective significance during CNS pathology.

Identification and characterization of a population of motile neurons in long-term cortical culture.

Acute reactive and regenerative changes in mature cortical axons following injury.

Metallothionein-IIA promotes neurite growth via the megalin receptor.

Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury.

Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival.

Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain.

Prolonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis.

The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.

Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes.

Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration.

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro.

Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins.

Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy.

Recent rodent models for Alzheimer's disease: clinical implications and basic research.

Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice.

Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.

Redox-active Cu(II)-Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner.

Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice.

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.

Editorial: The molecular pathology of cognitive decline: focus on metals.

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia.

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation.

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.

Ultrastructural Mapping of the Zebrafish Gastrointestinal System as a Basis for Experimental Drug Studies.