College of Pharmacy and Institute of Pharmaceutical Science and Technology
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Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.
Biochemical and biophysical research communications Jun, 2003 | Pubmed ID: 12767926
Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.
Molecular biology of the cell Oct, 2003 | Pubmed ID: 14517333
Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
The Journal of cell biology Jul, 2006 | Pubmed ID: 16801388
Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells.
The Journal of pharmacology and experimental therapeutics Dec, 2006 | Pubmed ID: 16973888
Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis.
Apoptosis : an international journal on programmed cell death Jul, 2007 | Pubmed ID: 17252195
ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells.
The international journal of biochemistry & cell biology Jun, 2009 | Pubmed ID: 19154794
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
Molecular and cellular biology May, 2009 | Pubmed ID: 19289504
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21041660
Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2011 | Pubmed ID: 21228219
DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2).
Biochimica et biophysica acta Apr-Jun, 2011 | Pubmed ID: 21362508
Nek1 and TAZ interact to maintain normal levels of polycystin 2.
Journal of the American Society of Nephrology : JASN May, 2011 | Pubmed ID: 21474562
Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.
Cell cycle (Georgetown, Tex.) May, 2011 | Pubmed ID: 21519187
Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis.
Protein & cell Jul, 2011 | Pubmed ID: 21822799
The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.
PloS one , 2012 | Pubmed ID: 23029531
Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm.
Journal of cellular physiology Jun, 2013 | Pubmed ID: 23129444
The accumulation of DNA repair defects is the molecular origin of carcinogenesis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Dec, 2013 | Pubmed ID: 23907577
Current clinical trials with polo-like kinase 1 inhibitors in solid tumors.
Anti-cancer drugs Nov, 2013 | Pubmed ID: 23949254
Two nuclear export signals of Cdc6 are differentially associated with CDK-mediated phosphorylation residues for cytoplasmic translocation.
Biochimica et biophysica acta Feb, 2014 | Pubmed ID: 24216307
Synergistic effect of simvastatin plus NS398 on inhibition of proliferation and survival in hepatocellular carcinoma cell line.
Journal of gastroenterology and hepatology Jun, 2014 | Pubmed ID: 24372723
ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α-induced apoptosis of HeLa cells.
FEBS letters Mar, 2014 | Pubmed ID: 24530529
Plk1-targeted therapies in TP53- or RAS-mutated cancer.
Mutation research. Reviews in mutation research Mar, 2014 | Pubmed ID: 24630986
Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections.
Pediatric nephrology (Berlin, Germany) Nov, 2014 | Pubmed ID: 24924751
A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition.
Virology Nov, 2014 | Pubmed ID: 25146733
The tumor suppressor protein p150(Sal2) in carcinogenesis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Feb, 2015 | Pubmed ID: 25608837
Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.
Journal of cellular physiology Dec, 2015 | Pubmed ID: 25975351
Antiinflammatory and analgesic effects of Eurycoma longifolia extracts.
Archives of pharmacal research Mar, 2016 | Pubmed ID: 26832325
Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.
Journal of cellular physiology Nov, 2016 | Pubmed ID: 27861885
Roles of SALL2 in tumorigenesis.
Archives of pharmacal research Feb, 2017 | Pubmed ID: 27957650
Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy.
Anticancer research 03, 2017 | Pubmed ID: 28314279
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