Mechanical Engineering and Materials Science
Dr. Li is an Associate Professor in the Division of Gastroenetrology, Department of Internal Medicine, the University of Texas Medical Branch at Galveston. He received
his Master’s Degree in Organic Chemistry from Guangxi Normal University, and a PhD in Biochemistry and Molecular Biology from Central South University, China.
He received his postdoctoral training in Dr. Roderick Dashwood's laboratory at the Linus Pauling Institute, Oregon State University, where he worked on molecular mechanisms and chemoprevention of colorectal cancer. He joined UTMB as a faculty member in 2006.
Dr. Li’s research interests lie in inflammatory bowel disease (IBD), a complex GI disease associated with lifelong medical attention, poor quality of life and huge economic burden, as well as in IBD-associated disorders, including colitis-associated cancer and IBD-induced cardiovascular diseases. Decades of research suggests that the pathogenesis of IBD, including Crohn’s disease and ulcerative colitis, involves abnormal gut microbiota, immune response dysregulation, environmental factors and genetic susceptibility. Specifically, Dr. Li’s research interests include:
• Epigenetic and bacterial contributions to the development of IBD and colitis-associated cancer (CAC);
• Molecular mechanisms underlying IBD-associated cardiovascular disorders;
• Identification of biomarkers and therapeutic targets in IBD and CAC;
• Development of small molecule drugs targeting TRAF6 and MMP7 in inflammatory diseases;
• Phytochemicals as chemopreventive agents against IBD and extraintestinal manifestations of IBD.
The influence of central corneal thickness and corneal curvature and axial length on the measurement of intraocular pressure.
Yan ke xue bao = Eye science Sep, 2002 | Pubmed ID: 15510750
[Changes of corneal endothelium morphology and thickness after secondary intraocular lens implantation of traumatic aphakia].
Yan ke xue bao = Eye science Jun, 2007 | Pubmed ID: 17867513
[Study of the difference of ocular surface change and restoration after two correction surgeries of congenital ptosis].
Yan ke xue bao = Eye science Dec, 2007 | Pubmed ID: 18303670
[E1A gene transfection of human undifferentiated thyroid cancer cell line HTC/3 by nanoparticles].
Zhonghua zhong liu za zhi [Chinese journal of oncology] Dec, 2007 | Pubmed ID: 18478924
[Cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. tree 1-7 on human hepatoma cell line HepG2].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials Jun, 2008 | Pubmed ID: 18998570
[Exploration of lymphangiogenesis in alkali burned human cornea].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology Feb, 2009 | Pubmed ID: 19573329
[A comparison of three methods in establishing transplanted model of VX2 tongue carcinoma in rabbits].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Jun, 2009 | Pubmed ID: 19637489
Serum uric acid levels and neuromyelitis optica.
Journal of neurology Jun, 2010 | Pubmed ID: 20094725
SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.
British journal of pharmacology Feb, 2010 | Pubmed ID: 20128807
Highly efficient synthesis of a class of novel chiral-bridged atropisomeric monophosphine ligands via simple desymmetrization and their applications in asymmetric Suzuki-Miyaura coupling reaction.
Organic letters Apr, 2012 | Pubmed ID: 22482994
Highly efficient synthesis of heterocyclic and alicyclic β2-amino acid derivatives by catalytic asymmetric hydrogenation.
Chemistry, an Asian journal Sep, 2013 | Pubmed ID: 23776190
Zopolrestat as a human glyoxalase I inhibitor and its structural basis.
ChemMedChem Sep, 2013 | Pubmed ID: 23857942
Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111).
FEBS letters Nov, 2013 | Pubmed ID: 24100137
Enantioselective synthesis of axially chiral multifunctionalized biaryls via asymmetric Suzuki-Miyaura coupling.
Organic letters Nov, 2013 | Pubmed ID: 24138017
The effect of a telephone follow-up intervention on illness perception and lifestyle after myocardial infarction in China: a randomized controlled trial.
International journal of nursing studies Jun, 2014 | Pubmed ID: 24211192
Single molecule mechanical manipulation for studying biological properties of proteins, DNA, and sugars.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology May-Jun, 2014 | Pubmed ID: 24347439
Structural basis for the inhibition of AKR1B10 by caffeic acid phenethyl ester (CAPE).
ChemMedChem Apr, 2014 | Pubmed ID: 24436249
Relationship of karyotype to embryo crown-rump length and maternal serum human chorionic gonadotropin level in early miscarriage.
American journal of perinatology Jan, 2015 | Pubmed ID: 24705969
MicroRNA profiling implies new markers of chemoresistance of triple-negative breast cancer.
PloS one , 2014 | Pubmed ID: 24788655
Divalent metal ion-based catalytic mechanism of the Nudix hydrolase Orf153 (YmfB) from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography May, 2014 | Pubmed ID: 24816099
Structure of human endonuclease V as an inosine-specific ribonuclease.
Acta crystallographica. Section D, Biological crystallography Sep, 2014 | Pubmed ID: 25195743
Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies.
Biomedical chromatography : BMC Oct, 2014 | Pubmed ID: 25294592
A strategy for fabricating nanoporous gold films through chemical dealloying of electrochemically deposited Au-Sn alloys.
Nanotechnology Nov, 2014 | Pubmed ID: 25325248
Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes.
Angewandte Chemie (International ed. in English) Dec, 2014 | Pubmed ID: 25339429
Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer.
Journal of translational medicine Feb, 2015 | Pubmed ID: 25638150
Functional evolution of phosphatidylethanolamine binding proteins in soybean and Arabidopsis.
The Plant cell Feb, 2015 | Pubmed ID: 25663621
Dose-response relationship in cisplatin-treated breast cancer xenografts monitored with dynamic contrast-enhanced ultrasound.
BMC cancer Mar, 2015 | Pubmed ID: 25884471
Surgical Strategy for Hepatocellular Carcinoma Patients with Portal/Hepatic Vein Tumor Thrombosis.
PloS one , 2015 | Pubmed ID: 26076461
Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells.
Natural product research Jul, 2016 | Pubmed ID: 26158392
A targeted IL-15 fusion protein with potent anti-tumor activity.
Cancer biology & therapy , 2015 | Pubmed ID: 26176990
In Vitro Inhibition of Glyoxalase І by Flavonoids: New Insights from Crystallographic Analysis.
Current topics in medicinal chemistry , 2016 | Pubmed ID: 26268338
Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor.
Acta pharmacologica Sinica Sep, 2015 | Pubmed ID: 26279158
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Chemico-biological interactions Oct, 2015 | Pubmed ID: 26362498
The Degree of Contrast Washout on Contrast-Enhanced Ultrasound in Distinguishing Intrahepatic Cholangiocarcinoma from Hepatocellular Carcinoma.
Ultrasound in medicine & biology Dec, 2015 | Pubmed ID: 26386477
Characterization and machine learning prediction of allele-specific DNA methylation.
Genomics Dec, 2015 | Pubmed ID: 26407641
A novel bispecific antibody, S-Fab, induces potent cancer cell killing.
Journal of immunotherapy (Hagerstown, Md. : 1997) Nov-Dec, 2015 | Pubmed ID: 26448579
Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib.
PloS one , 2015 | Pubmed ID: 26513662
National consensus in China on diagnosis and treatment of patients with advanced breast cancer.
Annals of translational medicine Oct, 2015 | Pubmed ID: 26605288
Contamination and distribution of heavy metals, polybrominated diphenyl ethers and alternative halogenated flame retardants in a pristine mangrove.
Marine pollution bulletin Feb, 2016 | Pubmed ID: 26759186
Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis.
The Journal of biological chemistry Mar, 2016 | Pubmed ID: 26797133
A novel bispecific antibody, BiSS, with potent anti-cancer activities.
Cancer biology & therapy 04, 2016 | Pubmed ID: 26828900
Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease.
Cardiology , 2016 | Pubmed ID: 26985667
Research on supporting mounts of spheres in measurement of gravitational constant G.
The Review of scientific instruments Mar, 2016 | Pubmed ID: 27036796
Cholesterol efflux capacity is an independent predictor of all-cause and cardiovascular mortality in patients with coronary artery disease: A prospective cohort study.
Atherosclerosis 06, 2016 | Pubmed ID: 27088866
A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells.
AMB Express Dec, 2016 | Pubmed ID: 27112931
Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.
Molecular and cellular biology 07, 2016 | Pubmed ID: 27141053
In vitro CAPE inhibitory activity towards human AKR1C3 and the molecular basis.
Chemico-biological interactions Jun, 2016 | Pubmed ID: 27163852
Bispecific antibodies in cancer immunotherapy.
Human vaccines & immunotherapeutics 10, 2016 | Pubmed ID: 27249163
Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein.
The Journal of biological chemistry 08, 2016 | Pubmed ID: 27378818
SPARC overexpression in primary tumors correlates with disease recurrence and overall survival in patients with triple negative breast cancer.
Oncotarget 11, 2016 | Pubmed ID: 27421134
Estimated Glomerular Filtration Rate and Mortality among Patients with Coronary Heart Disease.
PloS one , 2016 | Pubmed ID: 27537335
Metabolic syndrome and its individual components with mortality among patients with coronary heart disease.
International journal of cardiology Dec, 2016 | Pubmed ID: 27599384
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
BMC cancer 09, 2016 | Pubmed ID: 27613518
Single domain antibody-based bispecific antibody induces potent specific anti-tumor activity.
Cancer biology & therapy 12, 2016 | Pubmed ID: 27645568
Association Between Serum Fibroblast Growth Factor 21 and Mortality Among Patients With Coronary Artery Disease.
The Journal of clinical endocrinology and metabolism 12, 2016 | Pubmed ID: 27662438
Prediction of the risk of mortality using risk score in patients with coronary heart disease.
Oncotarget Dec, 2016 | Pubmed ID: 27835576
Erratum to: 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
BMC cancer 11, 2016 | Pubmed ID: 27899080
Cobalt Chloride-induced Hypoxia Induces Epithelial-mesenchymal Transition in Renal Carcinoma Cell Lines.
Annals of clinical and laboratory science Jan, 2017 | Pubmed ID: 28249915
Noninvasive fetal genotyping of paternally inherited alleles using targeted massively parallel sequencing in parentage testing cases.
Transfusion 06, 2017 | Pubmed ID: 28295384
Fish oil supplementation inhibits endoplasmic reticulum stress and improves insulin resistance: involvement of AMP-activated protein kinase.
Food & function Apr, 2017 | Pubmed ID: 28327709
Retinol Binding Protein-4 Levels and Non-alcoholic Fatty Liver Disease: A community-based cross-sectional study.
Scientific reports Mar, 2017 | Pubmed ID: 28332619
Vascular Endothelial Growth Inhibitor, a Cytokine of the Tumor Necrosis Factor Family, is Associated With Epithelial-Mesenchymal Transition in Renal Cell Carcinoma.
Applied immunohistochemistry & molecular morphology : AIMM Mar, 2017 | Pubmed ID: 28362712
N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway.
Molecular nutrition & food research Sep, 2017 | Pubmed ID: 28371258
An SNP panel for the analysis of paternally inherited alleles in maternal plasma using ion Torrent PGM.
International journal of legal medicine Mar, 2018 | Pubmed ID: 28429088
Intra-tumour molecular heterogeneity of clear cell renal cell carcinoma reveals the diversity of the response to targeted therapies using patient-derived xenograft models.
Oncotarget Jul, 2017 | Pubmed ID: 28548943
A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.
The Journal of clinical investigation Jun, 2017 | Pubmed ID: 28604389
Vascular endothelial growth inhibitor 174 and its functional domains inhibit epithelial-mesenchymal transition in renal cell carcinoma cells in vitro.
International journal of molecular medicine Aug, 2017 | Pubmed ID: 28656288
Crystal Structure and Thermostability Characterization of Enterovirus D68 3D.
Journal of virology 09, 2017 | Pubmed ID: 28659472
Identification of Novel Proteins Interacting with Vascular Endothelial Growth Inhibitor 174 in Renal Cell Carcinoma.
Anticancer research 08, 2017 | Pubmed ID: 28739731
BiHC, a T-Cell-Engaging Bispecific Recombinant Antibody, Has Potent Cytotoxic Activity Against Her2 Tumor Cells.
Translational oncology Oct, 2017 | Pubmed ID: 28797938
Associations between serum calcium, phosphorus and mortality among patients with coronary heart disease.
European journal of nutrition Aug, 2017 | Pubmed ID: 28808770
Lower Plasma Fetuin-A Levels Are Associated With a Higher Mortality Risk in Patients With Coronary Artery Disease.
Arteriosclerosis, thrombosis, and vascular biology 11, 2017 | Pubmed ID: 28912366
Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation.
Stem cell research & therapy Sep, 2017 | Pubmed ID: 28927462
A Bispecific Antibody Based on Pertuzumab Fab Has Potent Antitumor Activity.
Journal of immunotherapy (Hagerstown, Md. : 1997) Jan, 2018 | Pubmed ID: 29232309
Barriers to Acupuncture Use Among Breast Cancer Survivors: A Cross-Sectional Analysis.
Integrative cancer therapies 09, 2018 | Pubmed ID: 29338443
Assessment of the cardiac safety between cetuximab and panitumumab as single therapy in Chinese chemotherapy-refractory mCRC.
OncoTargets and therapy , 2018 | Pubmed ID: 29343971
Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells.
PloS one , 2018 | Pubmed ID: 29357376
Ultrasonic RF time series for early assessment of the tumor response to chemotherapy.
Oncotarget Jan, 2018 | Pubmed ID: 29416800
Surface-Assisted Alkane Polymerization: Investigation on Structure-Reactivity Relationship.
Journal of the American Chemical Society 04, 2018 | Pubmed ID: 29432011
A Single Domain-Based Anti-Her2 Antibody Has Potent Antitumor Activities.
Translational oncology Apr, 2018 | Pubmed ID: 29455083
A targeted transforming growth factor-beta (TGF-β) blocker, TTB, inhibits tumor growth and metastasis.
Oncotarget May, 2018 | Pubmed ID: 29796175
Cyanidin-3-o-β-Glucoside Induces Megakaryocyte Apoptosis via PI3K/Akt- and MAPKs-Mediated Inhibition of NF-κB Signalling.
Thrombosis and haemostasis Jul, 2018 | Pubmed ID: 29864778
Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.
Cell death & disease Jun, 2018 | Pubmed ID: 29880854
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy.
International journal of nanomedicine , 2018 | Pubmed ID: 29881272
A HER2 bispecific antibody can be efficiently expressed in with potent cytotoxicity.
Oncology letters Jul, 2018 | Pubmed ID: 29963199
Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase.
Biophysical journal Jul, 2018 | Pubmed ID: 29972811
Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors.
European journal of cancer (Oxford, England : 1990) Sep, 2018 | Pubmed ID: 30014974
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
Nature chemical biology Sep, 2018 | Pubmed ID: 30120361
Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.
The Journal of biological chemistry Oct, 2018 | Pubmed ID: 30154244
The Emerging Role of Ras Pathway Signaling in Pediatric Cancer.
Cancer research 12, 2020 | Pubmed ID: 32907837
Oncogenic N-Ras Mitigates Oxidative Stress-Induced Apoptosis of Hematopoietic Stem Cells.
Cancer research 03, 2021 | Pubmed ID: 33441311
1Department of Pathology, University of Michigan, Ann Arbor,
2Department of Internal Medicine, University of Michigan, Ann Arbor,
3Department of Cellular and Developmental Biology, University of Michigan, Ann Arbor,
4Rogel Cancer Center, University of Michigan, Ann Arbor,
5Institute of Gerontology, University of Michigan, Ann Arbor
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