Knight Cardiovascular Institute
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Bicyclic Systems Related to Taxol. A Direct Means for Implementing C-2 Oxygenation and Demonstration of the Feasibility of alpha-Ketol Equilibration in a Fully Oxygenated B-Ring Setting.
The Journal of organic chemistry Jan, 1998 | Pubmed ID: 11674054
Asymmetric synthesis of (1R,2S,3R)-gamma-methyl-cis-pentacin by a kinetic resolution protocol.
Chemical communications (Cambridge, England) Dec, 2002 | Pubmed ID: 12478808
Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
American journal of veterinary research Sep, 2003 | Pubmed ID: 13677390
Seasonal changes in plasma concentrations of cecum-derived amines in clinically normal ponies and ponies predisposed to laminitis.
American journal of veterinary research Sep, 2003 | Pubmed ID: 13677391
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
Carcinogenesis May, 2004 | Pubmed ID: 14688019
Current research and theories on the pathogenesis of acute laminitis in the horse.
Veterinary journal (London, England : 1997) Mar, 2004 | Pubmed ID: 14975387
Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction.
American journal of physiology. Heart and circulatory physiology Feb, 2005 | Pubmed ID: 15388507
Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses.
American journal of veterinary research Apr, 2005 | Pubmed ID: 15900943
Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidis.
The Journal of biological chemistry Sep, 2005 | Pubmed ID: 16006553
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours.
International journal of cancer Jan, 2006 | Pubmed ID: 16049974
A total synthesis of milbemycin G: approaches to the C1-C10-fragment and completion of the synthesis.
Organic & biomolecular chemistry Oct, 2005 | Pubmed ID: 16211101
Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course.
Cancer research Nov, 2005 | Pubmed ID: 16266991
Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells.
Haematologica Mar, 2006 | Pubmed ID: 16531271
Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis.
The Journal of nutrition Jul, 2006 | Pubmed ID: 16772511
Countermeasures for pasture-associated laminitis in ponies and horses.
The Journal of nutrition Jul, 2006 | Pubmed ID: 16772514
Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
Bioorganic & medicinal chemistry letters Dec, 2006 | Pubmed ID: 16973358
Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.
Cell cycle (Georgetown, Tex.) Oct, 2006 | Pubmed ID: 17102621
Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.
European journal of pharmacology Aug, 2007 | Pubmed ID: 17560569
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
Journal of medicinal chemistry Jul, 2007 | Pubmed ID: 17591762
Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis.
Journal of the American Veterinary Medical Association Nov, 2007 | Pubmed ID: 17975996
Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.
American journal of veterinary research Jan, 2008 | Pubmed ID: 18167097
Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.
American journal of veterinary research Feb, 2008 | Pubmed ID: 18241016
Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin.
American journal of veterinary research Mar, 2008 | Pubmed ID: 18312133
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.
Neuro-oncology Dec, 2008 | Pubmed ID: 18664619
Physiochemical drug properties associated with in vivo toxicological outcomes.
Bioorganic & medicinal chemistry letters Sep, 2008 | Pubmed ID: 18691886
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.
Cancer research Aug, 2008 | Pubmed ID: 18701506
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.
Blood Jan, 2009 | Pubmed ID: 18838613
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.
Bioorganic & medicinal chemistry letters Dec, 2008 | Pubmed ID: 18945617
Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex.
Journal of bacteriology Feb, 2009 | Pubmed ID: 19028895
Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK.
Veterinary immunology and immunopathology Jun, 2009 | Pubmed ID: 19108900
Prolonged detection of viral DNA in blood following life-threatening chickenpox in an immunocompromised child.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Feb, 2009 | Pubmed ID: 19109054
Equine laminitis: a journey to the dark side of venous.
Veterinary immunology and immunopathology Jun, 2009 | Pubmed ID: 19110318
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.
The Journal of pathology Jun, 2009 | Pubmed ID: 19373855
Recruitment of the ParG segregation protein to different affinity DNA sites.
Journal of bacteriology Jun, 2009 | Pubmed ID: 19376860
Airway vascular reactivity and vascularisation in human chronic airway disease.
Pulmonary pharmacology & therapeutics Oct, 2009 | Pubmed ID: 19409504
Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.
Cell cycle (Georgetown, Tex.) Jun, 2009 | Pubmed ID: 19411854
Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma.
PloS one , 2009 | Pubmed ID: 19584924
Hypercalcemia in acute lymphoblastic leukemia: an overview.
Journal of pediatric hematology/oncology Jun, 2009 | Pubmed ID: 19648791
Functional role of alpha2-adrenoceptor subtypes in the cooling-enhanced vasoconstriction of isolated cutaneous digital veins of the horse.
European journal of pharmacology Feb, 2010 | Pubmed ID: 19878669
Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia.
Haematologica Apr, 2010 | Pubmed ID: 19951974
The effect of cooling on the contractility of equine digital small lamellar arteries: modulating role of the endothelium.
Experimental physiology Oct, 2010 | Pubmed ID: 20660021
Corticosteroid-associated laminitis.
The Veterinary clinics of North America. Equine practice Aug, 2010 | Pubmed ID: 20699175
4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Bioorganic & medicinal chemistry letters Oct, 2010 | Pubmed ID: 20817449
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Apr, 2011 | Pubmed ID: 20921458
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.
Acta neuropathologica Dec, 2010 | Pubmed ID: 21046410
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.
Acta neuropathologica Mar, 2011 | Pubmed ID: 21267586
Vitamin D status in paediatric patients with cancer.
Pediatric blood & cancer Oct, 2011 | Pubmed ID: 21294242
Rapid diagnosis of medulloblastoma molecular subgroups.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2011 | Pubmed ID: 21325292
TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Apr, 2011 | Pubmed ID: 21357788
Adenosquamous carcinoma of the lung diagnosed by cytology?: a diagnostic dilemma.
Diagnostic cytopathology Sep, 2012 | Pubmed ID: 21416646
Ingroup identity as an obstacle to effective multiprofessional and interprofessional teamwork: findings from an ethnographic study of healthcare assistants in dementia care.
Journal of interprofessional care Sep, 2011 | Pubmed ID: 21635181
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Journal of medicinal chemistry Dec, 2011 | Pubmed ID: 22040023
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Acta neuropathologica Dec, 2011 | Pubmed ID: 22139329
The importance of biopsy following radiological diagnosis of relapsed medulloblastoma.
British journal of neurosurgery Aug, 2012 | Pubmed ID: 22168967
Burkitt's lymphoma.
Lancet (London, England) Mar, 2012 | Pubmed ID: 22333947
Ward features and stigma experiences of mental health service users in Belgium and England: a replication study.
The International journal of social psychiatry Sep, 2013 | Pubmed ID: 22723516
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors.
Bioorganic & medicinal chemistry letters Aug, 2012 | Pubmed ID: 22765900
Central nervous system lesions in Malawian children: identifying the treatable.
Transactions of the Royal Society of Tropical Medicine and Hygiene Sep, 2012 | Pubmed ID: 22818739
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Nature Aug, 2012 | Pubmed ID: 22832581
Treating childhood acute lymphoblastic leukemia in Malawi.
Haematologica Jan, 2013 | Pubmed ID: 22899578
Evaluation of a commercially available radioimmunoassay and species-specific ELISAs for measurement of high concentrations of insulin in equine serum.
American journal of veterinary research Oct, 2012 | Pubmed ID: 23013186
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies.
Acta neuropathologica Mar, 2013 | Pubmed ID: 23291781
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Aug, 2013 | Pubmed ID: 23835706
Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study.
Neuro-oncology Sep, 2013 | Pubmed ID: 23857707
Driving external chemistry optimization via operations management principles.
Drug discovery today Mar, 2014 | Pubmed ID: 23973340
Differential effects of allergen challenge on large and small airway reactivity in mice.
PloS one , 2013 | Pubmed ID: 24040180
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types.
Acta neuropathologica Dec, 2013 | Pubmed ID: 24212602
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.
Acta neuropathologica Feb, 2014 | Pubmed ID: 24264598
TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.
Acta neuropathologica Feb, 2014 | Pubmed ID: 24337442
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Journal of medicinal chemistry Feb, 2014 | Pubmed ID: 24432909
Cytogenetic prognostication within medulloblastoma subgroups.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Mar, 2014 | Pubmed ID: 24493713
Endothelial dysfunction in an ovine model of collagen-induced arthritis.
Journal of vascular research , 2014 | Pubmed ID: 24556586
Kaposi's sarcoma in children: an open randomised trial of vincristine, oral etoposide and a combination of vincristine and bleomycin.
European journal of cancer (Oxford, England : 1990) May, 2014 | Pubmed ID: 24636877
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
Journal of medicinal chemistry Jun, 2014 | Pubmed ID: 24819116
Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors.
Acta neuropathologica Jul, 2014 | Pubmed ID: 24879579
Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.
ACS medicinal chemistry letters Nov, 2011 | Pubmed ID: 24900269
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
ACS medicinal chemistry letters Jan, 2013 | Pubmed ID: 24900568
Intracystic interferon therapy in childhood craniopharyngioma: who, when and how?
Clinical endocrinology Jan, 2015 | Pubmed ID: 25059106
A short report on knowledge exchange through research-based theatre: 'inside out of mind'.
Social science & medicine (1982) Oct, 2014 | Pubmed ID: 25103152
Wilms tumour in Malawi: surgical staging to stratify postoperative chemotherapy?
Pediatric blood & cancer Dec, 2014 | Pubmed ID: 25213396
Effects of selective β1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis.
Critical care (London, England) Nov, 2014 | Pubmed ID: 25413250
SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings.
Pediatric blood & cancer Apr, 2015 | Pubmed ID: 25418957
Controlled Extraction Studies Applied to Polyvinyl Chloride and Polyethylene Materials: Conclusions from the ELSIE Controlled Extraction Pilot Study.
AAPS PharmSciTech Jun, 2015 | Pubmed ID: 25511807
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Cancer cell Jan, 2015 | Pubmed ID: 25533335
Perceptions, experiences and needs of patients with idiopathic pulmonary fibrosis.
Journal of advanced nursing May, 2015 | Pubmed ID: 25533573
Referral patterns for mediastinal staging with EBUS across a UK Lung Cancer Network: A report from the Manchester Cancer EBUS sub-group.
Lung cancer (Amsterdam, Netherlands) Apr, 2015 | Pubmed ID: 25703892
Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis.
PloS one , 2015 | Pubmed ID: 25950840
Outcome is unchanged by adding vincristine upfront to the Malawi 28-day protocol for endemic Burkitt lymphoma.
Pediatric blood & cancer Nov, 2015 | Pubmed ID: 26052841
Intraosseous infusion of the distal phalanx compared to systemic intravenous infusion for marimastat delivery to equine lamellar tissue.
Veterinary journal (London, England : 1997) Sep, 2015 | Pubmed ID: 26073286
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease.
American journal of physiology. Lung cellular and molecular physiology Nov, 2015 | Pubmed ID: 26386117
Acute equine laminitis: Exciting prospects afoot.
Veterinary journal (London, England : 1997) Nov, 2015 | Pubmed ID: 26403957
Nucleosome levels and toll-like receptor expression during high cut-off haemofiltration: a pilot assessment.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Dec, 2015 | Pubmed ID: 26640058
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
Journal of medicinal chemistry Mar, 2016 | Pubmed ID: 26756222
Divergent clonal selection dominates medulloblastoma at recurrence.
Nature Jan, 2016 | Pubmed ID: 26760213
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Acta neuropathologica Jun, 2016 | Pubmed ID: 27040285
EBUS-guided mediastinal lung cancer staging: monitoring of quality standards improves performance.
Thorax Aug, 2016 | Pubmed ID: 27146201
Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury.
Kidney international Jul, 2016 | Pubmed ID: 27165831
A School Passport as Part of a Protocol to Assist Educational Reintegration After Medulloblastoma Treatment in Childhood.
Pediatric blood & cancer Sep, 2016 | Pubmed ID: 27196034
HSJ AND SERCO INQUIRY. We must nurture all the apples on the NHS tree.
The Health service journal Feb, 2016 | Pubmed ID: 27526467
The impact of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with central nervous system (CNS) tumours: protocol for a systematic review and meta-analysis.
Systematic reviews Aug, 2016 | Pubmed ID: 27577246
Associations between Extending Access to Primary Care and Emergency Department Visits: A Difference-In-Differences Analysis.
PLoS medicine Sep, 2016 | Pubmed ID: 27598248
The use of anthracyclines in the treatment of endemic Burkitt lymphoma.
British journal of haematology Jun, 2017 | Pubmed ID: 27891583
Power, empowerment, and person-centred care: using ethnography to examine the everyday practice of unregistered dementia care staff.
Sociology of health & illness Feb, 2017 | Pubmed ID: 27891628
Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.
Journal of neuro-oncology Apr, 2017 | Pubmed ID: 28110411
Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis.
Stem cell research & therapy Feb, 2017 | Pubmed ID: 28173831
The policy work of piloting: Mobilising and managing conflict and ambiguity in the English NHS.
Social science & medicine (1982) Apr, 2017 | Pubmed ID: 28284538
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
Journal of medicinal chemistry Apr, 2017 | Pubmed ID: 28287730
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Pharmacogenetics and genomics Jun, 2017 | Pubmed ID: 28445188
Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse.
Open veterinary journal , 2017 | Pubmed ID: 28540255
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
The Lancet. Oncology Jul, 2017 | Pubmed ID: 28545823
Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.
Neuro-oncology Jun, 2017 | Pubmed ID: 28605510
Application of pattern recognition techniques for classification of pediatric brain tumors by in vivo 3T (1) H-MR spectroscopy-A multi-center study.
Magnetic resonance in medicine Aug, 2017 | Pubmed ID: 28786132
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