Bailey Simon

Bicyclic Systems Related to Taxol. A Direct Means for Implementing C-2 Oxygenation and Demonstration of the Feasibility of alpha-Ketol Equilibration in a Fully Oxygenated B-Ring Setting.

Asymmetric synthesis of (1R,2S,3R)-gamma-methyl-cis-pentacin by a kinetic resolution protocol.

Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.

Seasonal changes in plasma concentrations of cecum-derived amines in clinically normal ponies and ponies predisposed to laminitis.

Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.

Current research and theories on the pathogenesis of acute laminitis in the horse.

Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction.

Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses.

Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidis.

Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours.

A total synthesis of milbemycin G: approaches to the C1-C10-fragment and completion of the synthesis.

Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course.

Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells.

Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis.

Countermeasures for pasture-associated laminitis in ponies and horses.

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.

Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.

Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis.

Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.

Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.

Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin.

Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.

Physiochemical drug properties associated with in vivo toxicological outcomes.

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents.

Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex.

Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK.

Prolonged detection of viral DNA in blood following life-threatening chickenpox in an immunocompromised child.

Equine laminitis: a journey to the dark side of venous.

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

Recruitment of the ParG segregation protein to different affinity DNA sites.

Airway vascular reactivity and vascularisation in human chronic airway disease.

Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.

Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma.

Hypercalcemia in acute lymphoblastic leukemia: an overview.

Functional role of alpha2-adrenoceptor subtypes in the cooling-enhanced vasoconstriction of isolated cutaneous digital veins of the horse.

Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia.

The effect of cooling on the contractility of equine digital small lamellar arteries: modulating role of the endothelium.

Corticosteroid-associated laminitis.

4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.

Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables.

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.

Vitamin D status in paediatric patients with cancer.

Rapid diagnosis of medulloblastoma molecular subgroups.

TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas.

Adenosquamous carcinoma of the lung diagnosed by cytology?: a diagnostic dilemma.

Ingroup identity as an obstacle to effective multiprofessional and interprofessional teamwork: findings from an ethnographic study of healthcare assistants in dementia care.

Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.

The importance of biopsy following radiological diagnosis of relapsed medulloblastoma.

Burkitt's lymphoma.

Ward features and stigma experiences of mental health service users in Belgium and England: a replication study.

Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors.

Central nervous system lesions in Malawian children: identifying the treatable.

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Treating childhood acute lymphoblastic leukemia in Malawi.

Evaluation of a commercially available radioimmunoassay and species-specific ELISAs for measurement of high concentrations of insulin in equine serum.

DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies.

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.

Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study.

Driving external chemistry optimization via operations management principles.

Differential effects of allergen challenge on large and small airway reactivity in mice.

Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types.

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.

Cytogenetic prognostication within medulloblastoma subgroups.

Endothelial dysfunction in an ovine model of collagen-induced arthritis.

Kaposi's sarcoma in children: an open randomised trial of vincristine, oral etoposide and a combination of vincristine and bleomycin.

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.

Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors.

Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.

Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.

Intracystic interferon therapy in childhood craniopharyngioma: who, when and how?

A short report on knowledge exchange through research-based theatre: 'inside out of mind'.

Wilms tumour in Malawi: surgical staging to stratify postoperative chemotherapy?

Effects of selective β1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis.

SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings.

Controlled Extraction Studies Applied to Polyvinyl Chloride and Polyethylene Materials: Conclusions from the ELSIE Controlled Extraction Pilot Study.

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.

Perceptions, experiences and needs of patients with idiopathic pulmonary fibrosis.

Referral patterns for mediastinal staging with EBUS across a UK Lung Cancer Network: A report from the Manchester Cancer EBUS sub-group.

Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis.

Outcome is unchanged by adding vincristine upfront to the Malawi 28-day protocol for endemic Burkitt lymphoma.

Intraosseous infusion of the distal phalanx compared to systemic intravenous infusion for marimastat delivery to equine lamellar tissue.

Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease.

Acute equine laminitis: Exciting prospects afoot.

Nucleosome levels and toll-like receptor expression during high cut-off haemofiltration: a pilot assessment.

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Divergent clonal selection dominates medulloblastoma at recurrence.

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.

EBUS-guided mediastinal lung cancer staging: monitoring of quality standards improves performance.

Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury.

A School Passport as Part of a Protocol to Assist Educational Reintegration After Medulloblastoma Treatment in Childhood.

HSJ AND SERCO INQUIRY. We must nurture all the apples on the NHS tree.

The impact of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with central nervous system (CNS) tumours: protocol for a systematic review and meta-analysis.

Associations between Extending Access to Primary Care and Emergency Department Visits: A Difference-In-Differences Analysis.

The use of anthracyclines in the treatment of endemic Burkitt lymphoma.

Power, empowerment, and person-centred care: using ethnography to examine the everyday practice of unregistered dementia care staff.

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.

Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis.

The policy work of piloting: Mobilising and managing conflict and ambiguity in the English NHS.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.

Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse.

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.

Application of pattern recognition techniques for classification of pediatric brain tumors by in vivo 3T (1) H-MR spectroscopy-A multi-center study.