Paul Cohen
Laboratory of Molecular Metabolism
The Rockefeller University
Paul Cohen MD, PhD is the Albert Resnick, MD Assistant Professor and Head of the Laboratory of Molecular Metabolism at the Rockefeller University.
Dr. Cohen received his undergraduate degree from Harvard in 1996. He then entered the Tri-Institutional MD-PhD program, receiving his PhD in molecular genetics in 2003 from The Rockefeller University and his MD from Weill Cornell Medical College in 2004. He then completed clinical training in Internal Medicine at Columbia University Medical Center and in Cardiology at Brigham and Women’s Hospital.
He completed his postdoctoral research at Dana-Farber Cancer Institute and Harvard Medical School in Dr. Bruce Spiegelman’s laboratory. Dr. Cohen joined the faculty of Rockefeller in 2015 where his lab focuses on dissecting the mechanisms underpinning obesity-related diseases.
Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.
The Journal of experimental medicine Aug, 1998 | Pubmed ID: 9705958
Leptin-specific patterns of gene expression in white adipose tissue.
Genes & development Apr, 2000 | Pubmed ID: 10783168
Selective deletion of leptin receptor in neurons leads to obesity.
The Journal of clinical investigation Oct, 2001 | Pubmed ID: 11602618
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Science (New York, N.Y.) Jul, 2002 | Pubmed ID: 12114623
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2002 | Pubmed ID: 12177411
Stearoyl-CoA desaturase-1 and the metabolic syndrome.
Current drug targets. Immune, endocrine and metabolic disorders Dec, 2003 | Pubmed ID: 14683458
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
The Journal of clinical investigation Feb, 2004 | Pubmed ID: 14755338
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15096593
Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1).
The Journal of nutrition Sep, 2004 | Pubmed ID: 15333742
Induction of leptin receptor expression in the liver by leptin and food deprivation.
The Journal of biological chemistry Mar, 2005 | Pubmed ID: 15644325
Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18753616
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.
Diabetes Jul, 2015 | Pubmed ID: 26050670
The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.
Trends in endocrinology and metabolism: TEM Jan, 2016 | Pubmed ID: 26688472
In Vitro Approaches to Model and Study Communication Between Adipose Tissue and the Liver.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28244049
Role of Perivascular Adipose Tissue in Vascular Physiology and Pathology.
Hypertension (Dallas, Tex. : 1979) 05, 2017 | Pubmed ID: 28320849
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages.
Nature communications Apr, 2017 | Pubmed ID: 28367972
Adipose crosstalk with other cell types in health and disease.
Experimental cell research 11, 2017 | Pubmed ID: 28433698
Insights into the Link Between Obesity and Cancer.
Current obesity reports Jun, 2017 | Pubmed ID: 28434109
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.
The Journal of clinical investigation Dec, 2017 | Pubmed ID: 29083323
How does obesity lead to insulin resistance?
eLife Dec, 2017 | Pubmed ID: 29239299
Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.
Cell metabolism Jan, 2018 | Pubmed ID: 29320702
Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density.
Cell metabolism Jan, 2018 | Pubmed ID: 29320703
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