Malene Urbanus

Targeting, insertion, and localization of Escherichia coli YidC.

YidC and SecY mediate membrane insertion of a Type I transmembrane domain.

Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein.

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins.

The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening.

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.

Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.