Hiroshi Kawamoto

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.

Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay.

Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2.

The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cells.

Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains.

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.

Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice.

T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells.

Identification of the earliest prethymic T-cell progenitors in murine fetal blood.

Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation.

Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages.

Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques.

Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.

Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection.

Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.

Indication for neoadjuvant chemotherapy in patients with colorectal liver metastases based on a nomogram that predicts disease-free survival.

The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.

BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.

CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.

Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells.

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.

Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting.

Regeneration of tumor antigen-specific CTLs utilizing iPS technology.

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

Regeneration of CD8αβ T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity.

Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.

NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs.

Cloning and expansion of antigen-specific T cells using iPS cell technology: development of "off-the-shelf" T cells for the use in allogeneic transfusion settings.

Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells.

Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.

Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.

Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.

[Mass-Production of Tumor Antigen-Specific Cytotoxic T Lymphocytes Using the iPS Cell Technology-Development of "Off-the-Shelf T Cells"for the Use in Allogeneic Transfusion Settings].

High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer.

Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

[Mass-Production of Cytotoxic T Lymphocytes Regenerated from Pluripotent Stem Cells-To Target Solid Tumors].

A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.

Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings.

[The origin of blood cells and myeloid cells].

Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology.

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

Increase in the incidence of acute inflammatory reactions to injectable fillers during COVID-19 era.

Propionic Acid, Induced in Gut by an Inulin Diet, Suppresses Inflammation and Ameliorates Liver Ischemia and Reperfusion Injury in Mice.

Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.

Tracing the evolutionary history of blood cells to the unicellular ancestor of animals.

Murine breast cancers disorganize the liver transcriptome in a zonated manner.

Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression.

[Development of "Off the Shelf" T Cells for Cancer Immunotherapy].

SETBP1 is dispensable for normal and malignant hematopoiesis.

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.

Evolutionary reversion in tumorigenesis.