Ramnik J. Xavier

Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.

Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy.

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.

Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.

Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.

Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine.

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Identification of host proteins required for HIV infection through a functional genomic screen.

Defective signal transduction in B lymphocytes lacking presenilin proteins.

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Genome-wide association studies: a new window into immune-mediated diseases.

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

RNA interference screen for human genes associated with West Nile virus infection.

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

On the level: IRGM gene function is all about expression.

HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Differential requirement for CARMA1 in agonist-selected T-cell development.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.

Autophagy, immunity and human disease.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

Common variants at five new loci associated with early-onset inflammatory bowel disease.

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.

Characterization and analysis of human chordoma cell lines.

A systems biology viewpoint on autophagy in health and disease.

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

Crohn disease: a current perspective on genetics, autophagy and immunity.

Human IRGM gene "to be or not to be".

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Recurrent chromosomal copy number alterations in sporadic chordomas.

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.

Genetics and pathogenesis of inflammatory bowel disease.

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.

Image-based genome-wide siRNA screen identifies selective autophagy factors.

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Genome-wide siRNA screen for mediators of NF-κB activation.