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Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
Gastroenterology Jan, 2002 | Pubmed ID: 11781288
Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy.
Blood cells, molecules & diseases Mar-Apr, 2002 | Pubmed ID: 12064924
Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.
The American journal of pathology Feb, 2003 | Pubmed ID: 12547717
Colonic epithelial functional phenotype varies with type and phase of experimental colitis.
Gastroenterology Jul, 2003 | Pubmed ID: 12851880
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15075335
Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.
FEBS letters Jan, 2005 | Pubmed ID: 15670823
Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.
Molecular and cellular biology Jul, 2006 | Pubmed ID: 16809782
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2006 | Pubmed ID: 17172448
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
Nature genetics May, 2007 | Pubmed ID: 17435756
Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine.
Annals of medicine , 2007 | Pubmed ID: 17457716
AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17878165
DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.
Cellular signalling Jan, 2008 | Pubmed ID: 17980554
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
The Journal of clinical investigation Feb, 2008 | Pubmed ID: 18172556
Identification of host proteins required for HIV infection through a functional genomic screen.
Science (New York, N.Y.) Feb, 2008 | Pubmed ID: 18187620
Defective signal transduction in B lymphocytes lacking presenilin proteins.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18195359
Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.
Gut Jun, 2008 | Pubmed ID: 18272545
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Endocrine-related cancer Mar, 2008 | Pubmed ID: 18310291
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Biochemistry Jun, 2008 | Pubmed ID: 18484747
Neither hide nor hair: the difficulty of identifying useful disease biomarkers.
Gastroenterology Jun, 2008 | Pubmed ID: 18486617
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Nature genetics Aug, 2008 | Pubmed ID: 18587394
Genome-wide association studies: a new window into immune-mediated diseases.
Nature reviews. Immunology Aug, 2008 | Pubmed ID: 18654571
Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.
Gastroenterology Sep, 2008 | Pubmed ID: 18655788
RNA interference screen for human genes associated with West Nile virus infection.
Nature Sep, 2008 | Pubmed ID: 18690214
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.
American journal of respiratory cell and molecular biology Mar, 2009 | Pubmed ID: 18757306
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature Nov, 2008 | Pubmed ID: 18849966
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.
PloS one , 2008 | Pubmed ID: 18852889
Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2008 | Pubmed ID: 18981407
On the level: IRGM gene function is all about expression.
Autophagy Jan, 2009 | Pubmed ID: 19029815
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
International journal of cancer. Journal international du cancer Feb, 2009 | Pubmed ID: 19030186
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.
Cell Dec, 2008 | Pubmed ID: 19109899
Differential requirement for CARMA1 in agonist-selected T-cell development.
European journal of immunology Jan, 2009 | Pubmed ID: 19130560
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
Nature genetics Sep, 2008 | Pubmed ID: 19165925
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
Cell host & microbe Mar, 2009 | Pubmed ID: 19286138
A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19342671
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
Experimental cell research Jul, 2009 | Pubmed ID: 19371741
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
Nucleic acids research Aug, 2009 | Pubmed ID: 19491311
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
PLoS genetics Jun, 2009 | Pubmed ID: 19557189
Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.
Inflammatory bowel diseases Jan, 2010 | Pubmed ID: 19575363
A genome-wide genetic screen for host factors required for hepatitis C virus propagation.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19717417
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.
Cellular microbiology Jan, 2010 | Pubmed ID: 19747213
Autophagy, immunity and human disease.
Current opinion in gastroenterology Nov, 2009 | Pubmed ID: 19826372
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Nature Oct, 2009 | Pubmed ID: 19865172
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Nature genetics Dec, 2009 | Pubmed ID: 19915574
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Cell Dec, 2009 | Pubmed ID: 20064371
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
Nature genetics Apr, 2010 | Pubmed ID: 20228799
Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
Blood Jul, 2010 | Pubmed ID: 20410506
Characterization and analysis of human chordoma cell lines.
Spine Jun, 2010 | Pubmed ID: 20461036
A systems biology viewpoint on autophagy in health and disease.
Current opinion in gastroenterology Jul, 2010 | Pubmed ID: 20571384
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 20616063
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.
Developmental cell Jun, 2010 | Pubmed ID: 20627085
Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Genes & development Jul, 2010 | Pubmed ID: 20634317
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20660724
Crohn disease: a current perspective on genetics, autophagy and immunity.
Autophagy Apr, 2011 | Pubmed ID: 20729636
Human IRGM gene "to be or not to be".
Seminars in immunopathology Dec, 2010 | Pubmed ID: 20737271
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Inflammatory bowel diseases Jun, 2011 | Pubmed ID: 20872834
LRRK2 is involved in the IFN-gamma response and host response to pathogens.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2010 | Pubmed ID: 20921534
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
The Journal of cell biology Nov, 2010 | Pubmed ID: 21041446
Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.
Seminars in immunopathology Dec, 2010 | Pubmed ID: 21107575
Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.
PloS one , 2010 | Pubmed ID: 21217821
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
PLoS genetics , 2011 | Pubmed ID: 21249183
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Nature genetics Mar, 2011 | Pubmed ID: 21297633
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
PLoS pathogens Apr, 2011 | Pubmed ID: 21490959
Recurrent chromosomal copy number alterations in sporadic chordomas.
PloS one , 2011 | Pubmed ID: 21602918
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.
Autophagy Sep, 2011 | Pubmed ID: 21606681
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2011 | Pubmed ID: 21646294
A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
Infection and immunity Sep, 2011 | Pubmed ID: 21670171
Genetics and pathogenesis of inflammatory bowel disease.
Nature Jun, 2011 | Pubmed ID: 21677747
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
PloS one , 2011 | Pubmed ID: 21949742
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Nature genetics Nov, 2011 | Pubmed ID: 21983784
Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.
Inflammatory bowel diseases Oct, 2011 | Pubmed ID: 21994190
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature Dec, 2011 | Pubmed ID: 22020285
CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22075698
Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.
Inflammatory bowel diseases Jan, 2012 | Pubmed ID: 22271508
Genome-wide siRNA screen for mediators of NF-κB activation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22308454
Jenny M. Tam1,
Carlos E. Castro2,
Robert J. W. Heath3,
Michael K. Mansour1,
Michael L. Cardenas1,
Ramnik J. Xavier3,
Matthew J. Lang4,
Jatin M. Vyas1
1Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School,
2Department of Mechanical and Aerospace Engineering, The Ohio State University,
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School,
4Dept. of Chemical and Biomolecular Engineering, Vanderbilt University
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