Craig R. Roy

Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells.

The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter.

A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.

The Dot/lcm transporter of Legionella pneumophila: a bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts.

The road less traveled: transport of Legionella to the endoplasmic reticulum.

Exploitation of the endoplasmic reticulum by bacterial pathogens.

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites.

Eukaryotic cells and microbial pathogens: a familiar couple take centre stage.

Show me the substrates: modulation of host cell function by type IV secretion systems.

Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation.

Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle.

Immunity to vacuolar pathogens: what can we learn from Legionella?

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.

A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells.

The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation.

Bacterial subversion of the host secretory pathway.

Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages.

A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot/Icm system.

Effect of vitrector cutting rate on vitreous biopsy yield.

Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandins.

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

Pathogen-endoplasmic-reticulum interactions: in through the out door.

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.

Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila.

MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' disease.

Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems.

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.

NALP3: a key player in caspase-1 activation.

Effector proteins translocated by Legionella pneumophila: strength in numbers.

Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria.

Pathogen subversion of cell-intrinsic innate immunity.

Legionella pneumophila proteins that regulate Rab1 membrane cycling.

The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation.

Host cell processes that influence the intracellular survival of Legionella pneumophila.

Analyzing association of the endoplasmic reticulum with the legionella pneumophila-containing vacuoles by fluorescence microscopy.

Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors.

Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila.

Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm system.

Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.

A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles.

Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.

Bacterial FIC Proteins AMP Up Infection.

Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.

Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila.

Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b.

The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes.

Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.

Manipulation of host membrane machinery by bacterial pathogens.

Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins.

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein.

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.

Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Modulation of Rab GTPase function by a protein phosphocholine transferase.

The Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation.

Subversion of membrane transport pathways by vacuolar pathogens.

The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.

Vacuolar pathogens value membrane integrity.

Coxiella burnetii secretion systems.

The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.

Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages.

The capping domain in RalF regulates effector functions.

The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii.

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole.

Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain.

The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.

Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes.

Autophagy and bacterial infection: an evolving arms race.

A Rab-centric perspective of bacterial pathogen-occupied vacuoles.

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF.

Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.

Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.

The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion.

On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF.

Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors.

Structure and function of Fic proteins.

Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii.

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.

Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages.

Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole.

Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling.

Erratum for Kohler et al., Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole.

Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of Legionella Intracellular Infection.

MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis.

Autophagic targeting and avoidance in intracellular bacterial infections.

A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection.

DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens.

Multiple effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.

Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary.

Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System.

A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel.

remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers.

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii.

Screening effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication.

Biogenesis of the Spacious -Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3.

Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding.