James M Mathew

Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model.

The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generation.

Immune "tolerance profiles" in donor bone marrow infused kidney transplant patients using multiple ex vivo functional assays.

Microchimerism in promoting graft acceptance in clinical transplantation.

Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR.

Favorable effects of alemtuzumab on allospecific regulatory T-cell generation.

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients.

Genomic biomarkers correlate with HLA-identical renal transplant tolerance.

Inhibitory effects of belatacept on allospecific regulatory T-cell generation in humans.

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus.

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture.

Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection.

Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells.

Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells.

Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin.

Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses.

Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.

Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance.

Cellular and functional biomarkers of clinical transplant tolerance.

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.

Transcriptomic studies in tolerance: Lessons learned and the path forward.

Clinical transplant tolerance: Coming of age.

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants.

Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil.

Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus.

Author Correction: Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus.

Outstanding questions in transplantation: Tolerance.

Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus.

Cell therapy can enable minimization of immunosuppression.