Department of Biochemistry and Biophysics
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Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.
The Journal of cell biology Apr, 2002 | Pubmed ID: 11927603
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.
The Journal of cell biology Jun, 2002 | Pubmed ID: 12070132
Golgi architecture and inheritance.
Annual review of cell and developmental biology , 2002 | Pubmed ID: 12142281
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor.
The EMBO journal Jul, 2003 | Pubmed ID: 12839990
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers.
Science (New York, N.Y.) Jun, 2004 | Pubmed ID: 15155912
Navigating the ClpB channel to solution.
Nature structural & molecular biology Jan, 2005 | Pubmed ID: 15689967
A cryptic Rab1-binding site in the p115 tethering protein.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15878873
Prions as adaptive conduits of memory and inheritance.
Nature reviews. Genetics Jun, 2005 | Pubmed ID: 15931169
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities.
Molecular cell Aug, 2006 | Pubmed ID: 16885031
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity.
Nature structural & molecular biology Feb, 2007 | Pubmed ID: 17259993
Prime time for alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2007 | Pubmed ID: 17344380
Hsp104: a weapon to combat diverse neurodegenerative disorders.
Neuro-Signals , 2008 | Pubmed ID: 18097161
Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.
Cell Dec, 2007 | Pubmed ID: 18160044
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18162536
Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.
PloS one , 2008 | Pubmed ID: 18335038
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Proceedings of the National Academy of Sciences of the United States of America May, 2008 | Pubmed ID: 18480256
Escaping amyloid fate.
Nature structural & molecular biology Jun, 2008 | Pubmed ID: 18523464
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
The Journal of clinical investigation Sep, 2008 | Pubmed ID: 18704197
A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells.
Traffic (Copenhagen, Denmark) Nov, 2008 | Pubmed ID: 18764819
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.
The EMBO journal Oct, 2008 | Pubmed ID: 18833196
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching.
The Journal of cell biology Dec, 2008 | Pubmed ID: 19029339
Prion proteostasis: Hsp104 meets its supporting cast.
Prion Oct-Dec, 2008 | Pubmed ID: 19242125
Motor mechanism for protein threading through Hsp104.
Molecular cell Apr, 2009 | Pubmed ID: 19362537
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19465477
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19840945
A synergistic small-molecule combination directly eradicates diverse prion strain structures.
Nature chemical biology Dec, 2009 | Pubmed ID: 19915541
Applying Hsp104 to protein-misfolding disorders.
Biochemistry and cell biology = Biochimie et biologie cellulaire Feb, 2010 | Pubmed ID: 20130674
Prion-like disorders: blurring the divide between transmissibility and infectivity.
Journal of cell science Apr, 2010 | Pubmed ID: 20356930
Emergence and natural selection of drug-resistant prions.
Molecular bioSystems Jul, 2010 | Pubmed ID: 20422111
Countering amyloid polymorphism and drug resistance with minimal drug cocktails.
Prion Oct-Dec, 2010 | Pubmed ID: 20935457
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.
PLoS biology Apr, 2011 | Pubmed ID: 21541367
Shock and awe: unleashing the heat shock response to treat Huntington disease.
The Journal of clinical investigation Aug, 2011 | Pubmed ID: 21785212
The elusive middle domain of Hsp104 and ClpB: Location and function.
Biochimica et biophysica acta Jan, 2012 | Pubmed ID: 21843558
RNA-binding proteins with prion-like domains in ALS and FTLD-U.
Prion Jul, 2011 | Pubmed ID: 21847013
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.
PloS one , 2011 | Pubmed ID: 22022600
A yeast functional screen predicts new candidate ALS disease genes.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22065782
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.
Brain research Jun, 2012 | Pubmed ID: 22445064
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.
Human molecular genetics Apr, 2012 | Pubmed ID: 22454397
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans.
PLoS biology , 2012 | Pubmed ID: 22723742
RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration.
Neurology research international , 2012 | Pubmed ID: 22919483
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Nature genetics Dec, 2012 | Pubmed ID: 23104007
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.
Cell Nov, 2012 | Pubmed ID: 23141537
Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)].
Chemistry & biology Nov, 2012 | Pubmed ID: 23177195
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Nature Mar, 2013 | Pubmed ID: 23455423
Stress granules as crucibles of ALS pathogenesis.
The Journal of cell biology Apr, 2013 | Pubmed ID: 23629963
Fission yeast does not age under favorable conditions, but does so after stress.
Current biology : CB Oct, 2013 | Pubmed ID: 24035542
Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.
PLoS genetics , 2013 | Pubmed ID: 24039611
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.
The Journal of biological chemistry Jan, 2014 | Pubmed ID: 24280225
The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins.
Prion Nov-Dec, 2013 | Pubmed ID: 24401655
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Cell Jan, 2014 | Pubmed ID: 24439375
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
The Journal of clinical investigation Mar, 2014 | Pubmed ID: 24509083
Reversing deleterious protein aggregation with re-engineered protein disaggregases.
Cell cycle (Georgetown, Tex.) May, 2014 | Pubmed ID: 24694655
The Surprising Role of Amyloid Fibrils in HIV Infection.
Biology , 2012 | Pubmed ID: 24832047
A cellular system that degrades misfolded proteins and protects against neurodegeneration.
Molecular cell Jul, 2014 | Pubmed ID: 24882209
Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly.
Rare diseases (Austin, Tex.) , 2013 | Pubmed ID: 25002999
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Disease models & mechanisms Oct, 2014 | Pubmed ID: 25062688
Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.
The Biochemical journal Nov, 2014 | Pubmed ID: 25142005
Suramin inhibits hsp104 ATPase and disaggregase activity.
PloS one , 2014 | Pubmed ID: 25299406
Counteracting Semen-mediated Enhancement of HIV Infection and Enveloped Virus Infection by a Lysine-specific Molecular Tweezer.
AIDS research and human retroviruses Oct, 2014 | Pubmed ID: 25357741
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