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Akira Orimo

CR-UK Stromal-Tumour Interaction Group,
Paterson Institute for Cancer Research,
CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research

University of Manchester

BIOGRAPHY

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PUBLICATIONS

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.

Cell May, 2005 | Pubmed ID: 15882617

Stromal fibroblasts in cancer: a novel tumor-promoting cell type.

Cell cycle (Georgetown, Tex.) Aug, 2006 | Pubmed ID: 16880743

Heterogeneity of stromal fibroblasts in tumors.

Cancer biology & therapy Apr, 2007 | Pubmed ID: 18027438

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

Seminars in cell & developmental biology Feb, 2010 | Pubmed ID: 19857592

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.

Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21041659

The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients.

BMC cancer Oct, 2015 | Pubmed ID: 26480818

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.

Cell and tissue research 09, 2016 | Pubmed ID: 27506216

Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.

Respiratory research 03, 2017 | Pubmed ID: 28284212

INSTITUTIONS

University of Manchester

Juntendo University

Juntendo University Faculty of Medicine

JOVE ARTICLES

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Urszula M. Polanska^*,1,

Ahmet Acar^*,1,

Akira Orimo^1,2

¹CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research, University of Manchester,

²Atopy Research Center, Juntendo University

Medicine

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor

Yu Okazawa^1,2,

Kosuke Mizukoshi^1,2,

Yu Koyama^2,4,

Shoki Okubo⁵,

Hiromitsu Komiyama¹,

Yutaka Kojima¹,

Michitoshi Goto¹,

Sonoko Habu³,

Okio Hino²,

Kazuhiro Sakamoto¹,

Akira Orimo²

¹Department of Coloproctological Surgery, Juntendo University Faculty of Medicine,

²Department of Molecular Pathogenesis, Juntendo University Faculty of Medicine,

³Atopy Research Center, Juntendo University Faculty of Medicine,

⁴Department of Oral Pathobiological Science and Surgery, Tokyo Dental College,

⁵Department of Gastroenterology, Juntendo University Faculty of Medicine

Cancer Research

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Akira Orimo

CR-UK Stromal-Tumour Interaction Group,Paterson Institute for Cancer Research,CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research

University of Manchester

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor

CR-UK Stromal-Tumour Interaction Group,
Paterson Institute for Cancer Research,
CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research