Ocular and Stem Cell Translational Research Section,
National Eye Institute,
Ocular and Stem Cell Translational Research Section, National Eye Institute
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When pigment cells turn into neurons.
The Journal of investigative dermatology Oct, 2005 | Pubmed ID: 16185257
The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye.
Pigment cell research Oct, 2006 | Pubmed ID: 16965267
Src-dependent phosphorylation of ASAP1 regulates podosomes.
Molecular and cellular biology Dec, 2007 | Pubmed ID: 17893324
Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF.
Development (Cambridge, England) Mar, 2008 | Pubmed ID: 18272592
Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19171890
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.
Developmental biology Aug, 2009 | Pubmed ID: 19520072
The basic-helix-loop-helix-leucine zipper gene Mitf: analysis of alternative promoter choice and splicing.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20694671
The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells.
Pigment cell & melanoma research Feb, 2011 | Pubmed ID: 20846177
Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary.
Development (Cambridge, England) Mar, 2011 | Pubmed ID: 21247964
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
PLoS genetics Jul, 2012 | Pubmed ID: 22792072
Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis.
Development (Cambridge, England) Mar, 2013 | Pubmed ID: 23406904
Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.
PloS one , 2013 | Pubmed ID: 23555005
Efficient and rapid derivation of primitive neural stem cells and generation of brain subtype neurons from human pluripotent stem cells.
Stem cells translational medicine Nov, 2013 | Pubmed ID: 24113065
The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2013 | Pubmed ID: 24336726
Developing cellular therapies for retinal degenerative diseases.
Investigative ophthalmology & visual science Feb, 2014 | Pubmed ID: 24573369
PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF.
PLoS genetics , 2014 | Pubmed ID: 24875170
DiameterJ: A validated open source nanofiber diameter measurement tool.
Biomaterials Aug, 2015 | Pubmed ID: 26043061
Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2015 | Pubmed ID: 26269569
Dataset for the validation and use of DiameterJ an open source nanofiber diameter measurement tool.
Data in brief Dec, 2015 | Pubmed ID: 26380840
Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue.
Investigative ophthalmology & visual science Nov, 2015 | Pubmed ID: 26540654
Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Jun, 2016 | Pubmed ID: 27110730
In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications.
Stem cells translational medicine Jul, 2016 | Pubmed ID: 27400791
Training to Improve Precision and Accuracy in the Measurement of Fiber Morphology.
PloS one , 2016 | Pubmed ID: 27907145
A basis for comparison: sensitive authentication of stem cell derived RPE using physiological responses of intact RPE monolayers.
Stem cell and translational investigation , 2017 | Pubmed ID: 28286868
A switchable positive and negative air pressure device for efficient and gentle handling of nanofiber scaffolds.
The Review of scientific instruments Oct, 2017 | Pubmed ID: 29092483
MITF - A controls branching morphogenesis and nephron endowment.
PLoS genetics 12, 2017 | Pubmed ID: 29240767
Polarized Human Retinal Pigment Epithelium Exhibits Distinct Surface Proteome on Apical and Basal Plasma Membranes.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29264809
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.
Cell reports 01, 2018 | Pubmed ID: 29298421
Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates.
Investigative ophthalmology & visual science 03, 2018 | Pubmed ID: 29625461
Report of the international conference on manufacturing and testing of pluripotent stem cells.
Biologicals : journal of the International Association of Biological Standardization Nov, 2018 | Pubmed ID: 30150108
Identifying core biological processes distinguishing human eye tissues with precise systems-level gene expression analyses and weighted correlation networks.
Human molecular genetics 10, 2018 | Pubmed ID: 30239781
Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.
Investigative ophthalmology & visual science 12, 2018 | Pubmed ID: 30590377
Retinal stem cell transplantation: Balancing safety and potential.
Progress in retinal and eye research 03, 2020 | Pubmed ID: 31494256
High-yield, automated intracellular electrophysiology in retinal pigment epithelia.
Journal of neuroscience methods 12, 2019 | Pubmed ID: 31562888
Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?
Annual review of pharmacology and toxicology 01, 2020 | Pubmed ID: 31914900
CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.
eLife Apr, 2020 | Pubmed ID: 32234210
AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration.
Communications biology Dec, 2021 | Pubmed ID: 34887495
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
Nature communications Dec, 2021 | Pubmed ID: 34911940
In vitro disease modeling of oculocutaneous albinism type 1 and 2 using human induced pluripotent stem cell-derived retinal pigment epithelium.
Stem cell reports Jan, 2022 | Pubmed ID: 35021041
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration.
Experimental eye research Sep, 2022 | Pubmed ID: 35835183
Triphasic developmentally guided protocol to generate retinal pigment epithelium from induced pluripotent stem cells.
STAR protocols Sep, 2022 | Pubmed ID: 35880133
Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells.
Stem cell reports Nov, 2022 | Pubmed ID: 36306781
Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration.
Nature methods Jan, 2023 | Pubmed ID: 36550275
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report.
Stem cell research & therapy Mar, 2023 | Pubmed ID: 36978104
Protocol to generate endothelial cells, pericytes, and fibroblasts in one differentiation round from human-induced pluripotent stem cells.
STAR protocols May, 2023 | Pubmed ID: 37149860
Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy.
Pharmacology & therapeutics Jun, 2023 | Pubmed ID: 37385300
Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy.
Cold Spring Harbor perspectives in medicine Jul, 2023 | Pubmed ID: 37487631
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