Kapil Bharti

Ocular and Stem Cell Translational Research Section, National Institutes of Health

Affiliated withNational Institutes of Health National Institutes of Health (NIH)

Research Area

ChemistryBiology

Biography

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JoVE Journal Publications

Article Total : 3	Year
Publication title	2020
Publication title	2022
Publication title	2023

Other Publications

Article	Year
When pigment cells turn into neurons. The Journal of investigative dermatology\| PubMed ID: 16185257	2005
The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment cell research\| PubMed ID: 16965267	2006
Src-dependent phosphorylation of ASAP1 regulates podosomes. Molecular and cellular biology\| PubMed ID: 17893324	2007
Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development (Cambridge, England)\| PubMed ID: 18272592	2008
Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19171890	2009
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Developmental biology\| PubMed ID: 19520072	2009
The basic-helix-loop-helix-leucine zipper gene Mitf: analysis of alternative promoter choice and splicing. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20694671	2010
The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells. Pigment cell & melanoma research\| PubMed ID: 20846177	2011
Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development (Cambridge, England)\| PubMed ID: 21247964	2011
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS genetics\| PubMed ID: 22792072	2012
Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis. Development (Cambridge, England)\| PubMed ID: 23406904	2013
Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium. PloS one\| PubMed ID: 23555005	2013
Efficient and rapid derivation of primitive neural stem cells and generation of brain subtype neurons from human pluripotent stem cells. Stem cells translational medicine\| PubMed ID: 24113065	2013
The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24336726	2013
Developing cellular therapies for retinal degenerative diseases. Investigative ophthalmology & visual science\| PubMed ID: 24573369	2014
PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS genetics\| PubMed ID: 24875170	2014
DiameterJ: A validated open source nanofiber diameter measurement tool. Biomaterials\| PubMed ID: 26043061	2015
Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26269569	2015
Dataset for the validation and use of DiameterJ an open source nanofiber diameter measurement tool. Data in brief\| PubMed ID: 26380840	2015
Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue. Investigative ophthalmology & visual science\| PubMed ID: 26540654	2015
Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 27110730	2016
In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications. Stem cells translational medicine\| PubMed ID: 27400791	2016
Training to Improve Precision and Accuracy in the Measurement of Fiber Morphology. PloS one\| PubMed ID: 27907145	2016
A basis for comparison: sensitive authentication of stem cell derived RPE using physiological responses of intact RPE monolayers. Stem cell and translational investigation\| PubMed ID: 28286868	2017
A switchable positive and negative air pressure device for efficient and gentle handling of nanofiber scaffolds. The Review of scientific instruments\| PubMed ID: 29092483	2017
MITF - A controls branching morphogenesis and nephron endowment. PLoS genetics\| PubMed ID: 29240767	2017
Polarized Human Retinal Pigment Epithelium Exhibits Distinct Surface Proteome on Apical and Basal Plasma Membranes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29264809	2018
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells. Cell reports\| PubMed ID: 29298421	2018
Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates. Investigative ophthalmology & visual science\| PubMed ID: 29625461	2018
Report of the international conference on manufacturing and testing of pluripotent stem cells. Biologicals : journal of the International Association of Biological Standardization\| PubMed ID: 30150108	2018
Identifying core biological processes distinguishing human eye tissues with precise systems-level gene expression analyses and weighted correlation networks. Human molecular genetics\| PubMed ID: 30239781	2018
Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice. Investigative ophthalmology & visual science\| PubMed ID: 30590377	2018
Retinal stem cell transplantation: Balancing safety and potential. Progress in retinal and eye research\| PubMed ID: 31494256	2020
High-yield, automated intracellular electrophysiology in retinal pigment epithelia. Journal of neuroscience methods\| PubMed ID: 31562888	2019
Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet? Annual review of pharmacology and toxicology\| PubMed ID: 31914900	2020
CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. eLife\| PubMed ID: 32234210	2020
AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration. Communications biology\| PubMed ID: 34887495	2021
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nature communications\| PubMed ID: 34911940	2021
In vitro disease modeling of oculocutaneous albinism type 1 and 2 using human induced pluripotent stem cell-derived retinal pigment epithelium. Stem cell reports\| PubMed ID: 35021041	2022
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration. Experimental eye research\| PubMed ID: 35835183	2022
Triphasic developmentally guided protocol to generate retinal pigment epithelium from induced pluripotent stem cells. STAR protocols\| PubMed ID: 35880133	2022
Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells. Stem cell reports\| PubMed ID: 36306781	2022
Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration. Nature methods\| PubMed ID: 36550275	2023
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report. Stem cell research & therapy\| PubMed ID: 36978104	2023
Protocol to generate endothelial cells, pericytes, and fibroblasts in one differentiation round from human-induced pluripotent stem cells. STAR protocols\| PubMed ID: 37149860	2023
Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy. Pharmacology & therapeutics\| PubMed ID: 37385300	2023
Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy. Cold Spring Harbor perspectives in medicine\| PubMed ID: 37487631	2023