Ian A. Blair

A validated liquid chromatography/tandem mass spectrometry assay for cis-amminedichloro(2-methylpyridine)platinum(II) in human plasma ultrafiltrate.

4,5-Epoxy-2(E)-decenal-induced formation of 1,N(6)-etheno-2'-deoxyadenosine and 1,N(2)-etheno-2'-deoxyguanosine adducts.

Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.

Analysis of anticancer drugs and their metabolites by mass spectrometry.

A human melanoma xenograft in a nude rat responds to isolated limb perfusion with TNF plus melphalan.

Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.

A novel lipid hydroperoxide-derived cyclic covalent modification to histone H4.

Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry.

Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.

A novel lipid hydroperoxide-derived modification to arginine.

Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.

Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.

Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol.

Liquid chromatography/mass spectrometry analysis of bifunctional electrophiles and DNA adducts from vitamin C mediated decomposition of 15-hydroperoxyeicosatetraenoic acid.

Analysis of FeII-mediated decomposition of a linoleic acid-derived lipid hydroperoxide by liquid chromatography/mass spectrometry.

Dioxododecenoic acid: a lipid hydroperoxide-derived bifunctional electrophile responsible for etheno DNA adduct formation.

Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate.

Novel lipid hydroperoxide-derived hemoglobin histidine adducts as biomarkers of oxidative stress.

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

4-Hydroperoxy-2-nonenal-induced formation of 1,N2-etheno-2'-deoxyguanosine adducts.

Cyclooxygenase-2-mediated DNA damage.

Targeted chiral lipidomics analysis.

Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation.

Effect of immunoaffinity depletion of human serum during proteomic investigations.

Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry.

Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles.

Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard.

Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.

Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice.

Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells.

Liquid chromatography/tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomarkers of Alzheimer's disease.

Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry.

Characterization of a lipid hydroperoxide-derived RNA adduct in rat intestinal epithelial cells.

Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells.

基于蛋白质组学的策略以确定生物标志物和白血病的药理指标与 t(4;11) 易位。

Analysis of phosphorylation sites on focal adhesion kinase using nanospray liquid chromatography/multiple reaction monitoring mass spectrometry.

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.

Quantification of intracellular homocysteine by stable isotope dilution liquid chromatography/tandem mass spectrometry.

Convenient and efficient syntheses of 4-hydroxy-2(E)-nonenal and 4-oxo-2(E)-nonenal.

EBP, a program for protein identification using multiple tandem mass spectrometry datasets.

Endogenous glutathione adducts.

Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450.

LC/ESI/MS analysis of saturated and unsaturated fatty acids in rat intestinal epithelial cells.

Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells.

A novel 4-oxo-2(E)-nonenal-derived endogenous thiadiazabicyclo glutathione adduct formed during cellular oxidative stress.

Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.

Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells.

Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/MS).

Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides.

Analysis of the zebrafish proteome during embryonic development.

Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide.

Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preference.

Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues.

DNA adducts with lipid peroxidation products.

Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.

The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.

Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry.

Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor.

Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells.

Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity.

Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.

The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.

Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery.

TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry.

Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.

Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport.

Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry.

The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses.

5-Lipoxygenase-mediated endogenous DNA damage.

Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.

15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism.

15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation.

A 4-oxo-2(E)-nonenal-derived glutathione adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid.

Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems.

Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione.

Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer.

12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.

Analysis of endogenous glutathione-adducts and their metabolites.

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.

Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future.

A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

Stable-isotope dilution LC–MS for quantitative biomarker analysis.

Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.

20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice.

Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women.

Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling.

Deciphering the human platelet sheddome.

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells.

Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use.

A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.

Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model.

Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters.

CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).

Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its 15 metabolites by LC-MS.

Liquid chromatography/mass spectrometry of pre-ionized Girard P derivatives for quantifying estrone and its metabolites in serum from postmenopausal women.

Analysis of the human pancreatic stellate cell secreted proteome.

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols.

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

Rotenone-mediated changes in intracellular coenzyme A thioester levels: implications for mitochondrial dysfunction.

Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells.

SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards.

Relative Quantification of Serum Proteins from Pancreatic Ductal Adenocarcinoma Patients by Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry.