Andrew Worth

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin irritation. The European Centre for the Validation of Alternative Methods Skin Irritation Task Force report 2.

Structure-based classification of antibacterial activity.

The principles of validation and the ECVAM validation process.

ECVAM's activities on computer modelling and integrated testing.

Functional MRI activity characterization using response time shift estimates from curve evolution.

Measurement and modeling of human T cell kinetics.

Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.

Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.

Quantitative structure-activity relationships for human health effects: commonalities with other endpoints.

Rapid turnover of T cells in acute infectious mononucleosis.

Rapid turnover of effector-memory CD4(+) T cells in healthy humans.

Direct measurement of T cell subset kinetics in vivo in elderly men and women.

ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies.

B-cell kinetics in humans: rapid turnover of peripheral blood memory cells.

A modular approach to the ECVAM principles on test validity.

The evaluation of processed cancellous bovine bone as a bone graft substitute.

Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections.

Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.

Eye irritation.

Skin sensitisation.

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

Comparison of the applicability domain of a quantitative structure-activity relationship for estrogenicity with a large chemical inventory.

Quantitative structure-activity-activity and quantitative structure-activity investigations of human and rodent toxicity.

Model-based variational smoothing and segmentation for diffusion tensor imaging in the brain.

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.

In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection.

The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test.

The ECVAM international validation study on in vitro tests for acute skin irritation: selection of test chemicals.

A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals.

Modeling the structure-property relationships of nanoneedles: A journey toward nanomedicine.

Toxmatch--a chemical classification and activity prediction tool based on similarity measures.

Toward in silico approaches for investigating the activity of nanoparticles in therapeutic development.

The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+gamma/deltaTCR-CD45RO+ T-cell population.

Imaging diagnosis--traumatic myelopathy in a dog with incomplete ossification of the dorsal lamina of the atlas.

Structural motifs modulating the carcinogenic risk of aromatic amines.

Thresholds of toxicological concern for endocrine active substances in the aquatic environment.

Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.

Overcoming barriers to validation of non-animal partial replacement methods/Integrated Testing Strategies: the report of an EPAA-ECVAM workshop.

Structural analysis and predictive value of the rodent in vivo micronucleus assay results.

Computational methods to predict the reactivity of nanoparticles through structure-property relationships.

Computational toxicology at the European Commission's Joint Research Centre.

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.

Characterization of age-related changes in bovine CD8+ T-cells.

Computational nanotoxicology: Predicting toxicity of nanoparticles.

QSAR modeling of nanomaterials.

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

Use of computational tools in the field of food safety.

A theoretical framework for predicting the oxidative stress potential of oxide nanoparticles.

Recent advances in the molecular modeling of estrogen receptor-mediated toxicity.

Rapid prototype modeling and customized titanium plate fabrication for correction of a persistent hard palate defect in a dog.

Comparison between a novel bovine xenoimplant and autogenous cancellous bone graft in tibial tuberosity advancement.

Report of the EPAA-ECVAM workshop on the validation of Integrated Testing Strategies (ITS).

QSAR and metabolic assessment tools in the assessment of genotoxicity.

Applying quantitative structure-activity relationship approaches to nanotoxicology: Current status and future potential.

Training needs for toxicity testing in the 21st century: a survey-informed analysis.

The principles of validation and the ECVAM validation process.

Report of the workshop on the validation of QSARs and other computational prediction models.

Accelerated In Vivo Proliferation of Memory Phenotype CD4(+) T-cells in Human HIV-1 Infection Irrespective of Viral Chemokine Co-receptor Tropism.