Department of Internal Medicine
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Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor.
Tissue engineering Jul, 2006 | Pubmed ID: 16889518
In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice.
Hepatology (Baltimore, Md.) Jul, 2010 | Pubmed ID: 20578126
RGB marking facilitates multicolor clonal cell tracking.
Nature medicine Apr, 2011 | Pubmed ID: 21441917
Chimeric mouse model of hepatitis B virus infection.
Journal of hepatology Feb, 2012 | Pubmed ID: 21801701
New insight in the pathobiology of hepatitis B virus infection.
Gut May, 2012 | Pubmed ID: 22504921
Primary human hepatocytes from metabolic-disordered children recreate highly differentiated liver-tissue-like spheroids on alginate scaffolds.
Tissue engineering. Part A Jul, 2012 | Pubmed ID: 22612238
Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.
Oncology reports Sep, 2012 | Pubmed ID: 22710979
Experimental models and therapeutic approaches for HBV.
Seminars in immunopathology Jan, 2013 | Pubmed ID: 22898798
The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus.
Journal of hepatology May, 2013 | Pubmed ID: 23246506
Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection.
Journal of hepatology Mar, 2014 | Pubmed ID: 24280293
Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration.
Journal of hepatology Mar, 2014 | Pubmed ID: 24398036
Multiplexing clonality: combining RGB marking and genetic barcoding.
Nucleic acids research Apr, 2014 | Pubmed ID: 24476916
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Science (New York, N.Y.) Mar, 2014 | Pubmed ID: 24557838
Mouse models of hepatitis B and delta virus infection.
Journal of immunological methods Aug, 2014 | Pubmed ID: 24631647
Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism.
Hepatology (Baltimore, Md.) Nov, 2014 | Pubmed ID: 24711282
Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.
PloS one , 2014 | Pubmed ID: 24801208
Relevance of a full-length genomic RNA standard and a thermal-shock step for optimal hepatitis delta virus quantification.
Journal of clinical microbiology Sep, 2014 | Pubmed ID: 24989607
Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure.
World journal of gastroenterology Feb, 2015 | Pubmed ID: 25717260
Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection.
Journal of hepatology Aug, 2015 | Pubmed ID: 25795587
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Nature biotechnology May, 2015 | Pubmed ID: 25798937
Latest developments in the treatment of hepatitis B.
Minerva gastroenterologica e dietologica Mar, 2016 | Pubmed ID: 26448309
Hepatitis B and Delta Virus: Advances on Studies about Interactions between the Two Viruses and the Infected Hepatocyte.
Journal of clinical and translational hepatology Sep, 2015 | Pubmed ID: 26623269
The challenge of protecting without overprotecting: The two sides of myeloid-derived suppressor cells in hepatitis B viral infection.
Hepatology (Baltimore, Md.) Mar, 2016 | Pubmed ID: 26661682
Variability in long-term hepatitis B virus dynamics under antiviral therapy.
Journal of theoretical biology Feb, 2016 | Pubmed ID: 26723531
Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation.
Journal of hepatology May, 2016 | Pubmed ID: 26805671
Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer.
Tissue engineering. Part A 05, 2016 | Pubmed ID: 27068494
Experimental in vitro and in vivo models for the study of human hepatitis B virus infection.
Journal of hepatology Apr, 2016 | Pubmed ID: 27084033
Mechanism of Hepatitis B Virus Persistence in Hepatocytes and Its Carcinogenic Potential.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 06, 2016 | Pubmed ID: 27190317
Serum HBV pgRNA as a clinical marker for cccDNA activity.
Journal of hepatology 02, 2017 | Pubmed ID: 27826059
Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27975313
Haem oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice.
Liver international : official journal of the International Association for the Study of the Liver 08, 2017 | Pubmed ID: 27992676
Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo.
Gut 03, 2018 | Pubmed ID: 28428345
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
Nature medicine Jul, 2017 | Pubmed ID: 28604703
Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice.
Scientific reports 06, 2017 | Pubmed ID: 28623307
The Role of cccDNA in HBV Maintenance.
Viruses 06, 2017 | Pubmed ID: 28635668
Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection.
The Journal of clinical investigation Aug, 2017 | Pubmed ID: 28737510
Animal models of HBV infection.
Best practice & research. Clinical gastroenterology Jun, 2017 | Pubmed ID: 28774409
A novel orally available small molecule that inhibits hepatitis B virus expression.
Journal of hepatology 03, 2018 | Pubmed ID: 29079285
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
Gastroenterology 02, 2018 | Pubmed ID: 29079518
Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo.
Gut 01, 2019 | Pubmed ID: 29217749
Nonlytic Lymphocytes Engineered to Express Virus-Specific T-Cell Receptors Limit HBV Infection by Activating APOBEC3.
Gastroenterology 07, 2018 | Pubmed ID: 29550589
Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture.
Gastroenterology 11, 2018 | Pubmed ID: 30031767
Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes.
The Journal of infectious diseases 07, 2019 | Pubmed ID: 30923817
A global scientific strategy to cure hepatitis B.
The lancet. Gastroenterology & hepatology Jul, 2019 | Pubmed ID: 30981686
T cell receptor grafting allows virological control of Hepatitis B virus infection.
The Journal of clinical investigation 04, 2019 | Pubmed ID: 31039136
Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection.
Emerging microbes & infections , 2019 | Pubmed ID: 31179847
CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans.
Frontiers in immunology , 2019 | Pubmed ID: 31231382
Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes.
Hepatology (Baltimore, Md.) Sep, 2020 | Pubmed ID: 31925967
Epigenetic modulation in chronic hepatitis B virus infection.
Seminars in immunopathology 04, 2020 | Pubmed ID: 32185454
A novel method to precisely quantify hepatitis B virus covalently closed circular (ccc)DNA formation and maintenance.
Antiviral research 09, 2020 | Pubmed ID: 32726641
Murine hepatocytes do not support persistence of Hepatitis D virus mono-infection in vivo.
Liver international : official journal of the International Association for the Study of the Liver 02, 2021 | Pubmed ID: 32997847
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.
The Lancet. Neurology 11, 2020 | Pubmed ID: 33031735
cccDNA Maintenance in Chronic Hepatitis B - Targeting the Matrix of Viral Replication.
Infection and drug resistance , 2020 | Pubmed ID: 33149632
Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes.
Cell reports. Medicine Jul, 2020 | Pubmed ID: 33205065
Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
Gut Jan, 2021 | Pubmed ID: 33509930
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