Department of Molecular Physiology and Biophysics,
Carver College of Medicine,
Holden Comprehensive Cancer Center,
Department of Pathology,
Department of Urology,
Department of Radiation Oncology,
Department of Molecular Physiology and Biophysics, Carver College of Medicine,
Department of Pathology, Carver College of Medicine,
Department of Urology, Carver College of Medicine,
Department of Radiation Oncology, Carver College of Medicine
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Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton.
Current opinion in cell biology Oct, 1996 | Pubmed ID: 8939660
Dystroglycan inside and out.
Current opinion in cell biology Oct, 1999 | Pubmed ID: 10508656
Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2002 | Pubmed ID: 12040032
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy.
Nature Jul, 2002 | Pubmed ID: 12140559
Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization.
Neuron Jun, 2003 | Pubmed ID: 12797959
Spiculated periosteal response induced by intraosseous injection of 22Rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer patients.
The Prostate Dec, 2005 | Pubmed ID: 16032708
Disruption of perlecan binding and matrix assembly by post-translational or genetic disruption of dystroglycan function.
FEBS letters Aug, 2005 | Pubmed ID: 16098969
Assessing tumor growth and distribution in a model of prostate cancer metastasis using bioluminescence imaging.
Clinical & experimental metastasis , 2005 | Pubmed ID: 16703413
Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring.
Journal of cell science Oct, 2006 | Pubmed ID: 16968749
Chemotherapeutic agents up-regulate the cytomegalovirus promoter: implications for bioluminescence imaging of tumor response to therapy.
Cancer research Nov, 2007 | Pubmed ID: 17974988
Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2008 | Pubmed ID: 18781145
ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.
Molecular biology of the cell Apr, 2009 | Pubmed ID: 19225155
Endothelin-1 inhibits prostate cancer growth in vivo through vasoconstriction of tumor-feeding arterioles.
Cancer biology & therapy Apr, 2009 | Pubmed ID: 19242129
Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19244252
Dystroglycan is not required for maintenance of the luminal epithelial basement membrane or cell polarity in the mouse prostate.
The Prostate May, 2010 | Pubmed ID: 20054819
Bone-specific growth inhibition of prostate cancer metastasis by atrasentan.
Cancer biology & therapy Apr, 2010 | Pubmed ID: 20139704
ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20729552
The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.
Molecular cancer research : MCR Jul, 2011 | Pubmed ID: 21636682
An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate.
The Prostate Aug, 2011 | Pubmed ID: 21656824
Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?
Nature reviews. Urology Jun, 2011 | Pubmed ID: 21691304
Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer.
The American journal of pathology Jul, 2011 | Pubmed ID: 21703427
Eradication of metastatic renal cell carcinoma after adenovirus-encoded TNF-related apoptosis-inducing ligand (TRAIL)/CpG immunotherapy.
PloS one , 2012 | Pubmed ID: 22312440
Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23223448
Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization.
Clinical & experimental metastasis Apr, 2013 | Pubmed ID: 23224938
Resistance to fluid shear stress is a conserved biophysical property of malignant cells.
PloS one , 2012 | Pubmed ID: 23226552
Chronic chlorpyrifos exposure does not promote prostate cancer in prostate specific PTEN mutant mice.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer , 2013 | Pubmed ID: 23758150
Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma.
Molecular cancer research : MCR Jan, 2014 | Pubmed ID: 24002891
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.
PloS one , 2013 | Pubmed ID: 24367580
Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization.
Molecular cancer research : MCR Feb, 2015 | Pubmed ID: 25274489
Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis.
The American journal of pathology Dec, 2014 | Pubmed ID: 25455686
The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer.
Cancer biology & therapy , 2015 | Pubmed ID: 25455932
rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25480548
Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2015 | Pubmed ID: 25634994
Alterations in cancer cell mechanical properties after fluid shear stress exposure: a micropipette aspiration study.
Cell health and cytoskeleton Jan, 2015 | Pubmed ID: 25908902
Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis.
Clinical & experimental metastasis Aug, 2015 | Pubmed ID: 26070429
Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma.
Molecular cancer Jul, 2015 | Pubmed ID: 26220087
Individualization of Adjuvant Therapy After Radical Prostatectomy for Clinically Localized Prostate Cancer: Current Status and Future Directions.
Clinical genitourinary cancer Feb, 2016 | Pubmed ID: 26341039
CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion.
Cancer biology & therapy , 2015 | Pubmed ID: 26418968
α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway.
Cancer research 11, 2016 | Pubmed ID: 27680681
Inhibiting G protein βγ signaling blocks prostate cancer progression and enhances the efficacy of paclitaxel.
Oncotarget May, 2017 | Pubmed ID: 28415604
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Journal of natural products 07, 2017 | Pubmed ID: 28621943
A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.
PloS one , 2017 | Pubmed ID: 28841687
Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling.
Matrix biology : journal of the International Society for Matrix Biology 05, 2019 | Pubmed ID: 29753676
Biomechanics of the Circulating Tumor Cell Microenvironment.
Advances in experimental medicine and biology , 2018 | Pubmed ID: 30368755
High content screening identifies monensin as an EMT-selective cytotoxic compound.
Scientific reports 02, 2019 | Pubmed ID: 30718715
A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells.
Journal of biological methods , 2018 | Pubmed ID: 31453247
Alpha-dystroglycan staining pattern and mortality in patients undergoing radical prostatectomy with lymph node positive prostate cancer.
The Canadian journal of urology Dec, 2019 | Pubmed ID: 31860423
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.
Cell reports 03, 2020 | Pubmed ID: 32187555
Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis.
Frontiers in oncology , 2020 | Pubmed ID: 32346533
Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress.
Molecular & cellular oncology , 2020 | Pubmed ID: 32944626
Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging.
PloS one , 2020 | Pubmed ID: 32986721
Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism.
Scientific reports 10, 2020 | Pubmed ID: 33077776
Melanoma Brain Metastases in the Era of Targeted Therapy and Checkpoint Inhibitor Therapy.
Cancers Mar, 2021 | Pubmed ID: 33804910
Devon L. Moose1,2,
Sophia Williams-Perez3,
Renee Cafun1,
Benjamin L. Krog1,
Michael D. Henry1,2,4,5,6
1Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa,
2Holden Comprehensive Cancer Center, University of Iowa,
3MD program, Carver College of Medicine, University of Iowa,
4Department of Pathology, Carver College of Medicine, University of Iowa,
5Department of Urology, Carver College of Medicine, University of Iowa,
6Department of Radiation Oncology, Carver College of Medicine, University of Iowa
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