Berlin Institute for Medical Systems Biology (BIMSB)
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Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells.
Cell reports Sep, 2019 | Pubmed ID: 31553918
The embryo at single-cell transcriptome resolution.
Science (New York, N.Y.) 10, 2017 | Pubmed ID: 28860209
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4 and CD8 T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 01, 2018 | Pubmed ID: 29311309
Post-transcriptional Regulation by 3' UTRs Can Be Masked by Regulatory Elements in 5' UTRs.
Cell reports 03, 2018 | Pubmed ID: 29562178
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
Science (New York, N.Y.) 05, 2018 | Pubmed ID: 29674432
Spatiotemporal m(i)RNA Architecture and 3' UTR Regulation in the C. elegans Germline.
Developmental cell 12, 2018 | Pubmed ID: 30416012
Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis.
Cell reports 11, 2018 | Pubmed ID: 30485812
BCR-dependent lineage plasticity in mature B cells.
Science (New York, N.Y.) 02, 2019 | Pubmed ID: 30765568
FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control.
Nature methods 09, 2019 | Pubmed ID: 31384046
Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Nature communications 09, 2019 | Pubmed ID: 31527589
Gene expression cartography.
Nature 12, 2019 | Pubmed ID: 31748748
A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain.
Cell reports 02, 2020 | Pubmed ID: 32075758
Tracing tumorigenesis in a solid tumor model at single-cell resolution.
Nature communications 02, 2020 | Pubmed ID: 32080185
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 06, 2020 | Pubmed ID: 32522871
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia.
Molecular therapy : the journal of the American Society of Gene Therapy 12, 2020 | Pubmed ID: 32822592
LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature 11, 2020 | Pubmed ID: 32894860
Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients.
Journal of the American Society of Nephrology : JASN Feb, 2021 | Pubmed ID: 33239393
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature Apr, 2021 | Pubmed ID: 33731935
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications 03, 2021 | Pubmed ID: 33771987
Parallel genetics of regulatory sequences using scalable genome editing in vivo.
Cell reports Apr, 2021 | Pubmed ID: 33852857
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling.
Cell reports Mar, 2024 | Pubmed ID: 38446664
Widespread changes in protein synthesis induced by microRNAs.
Nature Sep, 2008 | Pubmed ID: 18668040
Mixed messages: Re-initiation factors regulate translation of animal mRNAs.
Cell research Dec, 2014 | Pubmed ID: 25145358
circBase: a database for circular RNAs.
RNA (New York, N.Y.) Nov, 2014 | Pubmed ID: 25234927
circRNA biogenesis competes with pre-mRNA splicing.
Molecular cell Oct, 2014 | Pubmed ID: 25242144
A variety of dicer substrates in human and C. elegans.
Cell Nov, 2014 | Pubmed ID: 25416952
Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals.
Cell reports Jan, 2015 | Pubmed ID: 25558066
Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
The EMBO journal May, 2015 | Pubmed ID: 25828096
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.
Molecular cell Jun, 2015 | Pubmed ID: 25921068
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Nature communications May, 2015 | Pubmed ID: 26007203
Extensive identification and analysis of conserved small ORFs in animals.
Genome biology Sep, 2015 | Pubmed ID: 26364619
RCAS: an RNA centric annotation system for transcriptome-wide regions of interest.
Nucleic acids research Jun, 2017 | Pubmed ID: 28334930
Cell fixation and preservation for droplet-based single-cell transcriptomics.
BMC biology 05, 2017 | Pubmed ID: 28526029
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Science (New York, N.Y.) Sep, 2017 | Pubmed ID: 28798046
A map of human circular RNAs in clinically relevant tissues.
Journal of molecular medicine (Berlin, Germany) Nov, 2017 | Pubmed ID: 28842720
RNA localization is a key determinant of neurite-enriched proteome.
Nature communications Sep, 2017 | Pubmed ID: 28928394
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Genome biology Oct, 2017 | Pubmed ID: 29089033
Single-Molecule Fluorescence In Situ Hybridization (FISH) of Circular RNA CDR1as.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29322442
A Single-Cell Transcriptome Atlas of the Mouse Glomerulus.
Journal of the American Society of Nephrology : JASN 08, 2018 | Pubmed ID: 29794128
The Translational Landscape of the Human Heart.
Cell Jun, 2019 | Pubmed ID: 31155234
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Nature communications Oct, 2019 | Pubmed ID: 31653857
NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport.
Nature protocols Sep, 2021 | Pubmed ID: 34349282
Spacemake: processing and analysis of large-scale spatial transcriptomics data.
GigaScience Jul, 2022 | Pubmed ID: 35852420
Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Kidney international Dec, 2022 | Pubmed ID: 36049643
SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution.
The Science of the total environment Dec, 2022 | Pubmed ID: 36228784
Long-term imaging reveals behavioral plasticity during C. elegans dauer exit.
BMC biology Dec, 2022 | Pubmed ID: 36514066
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Neuron Jul, 2023 | Pubmed ID: 37192624
Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Nature communications May, 2023 | Pubmed ID: 37230989
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Nature microbiology Jul, 2023 | Pubmed ID: 37349587
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Nature communications Jul, 2023 | Pubmed ID: 37402719
Spatiotemporal, optogenetic control of gene expression in organoids.
Nature methods Oct, 2023 | Pubmed ID: 37735569
Stephanie Le1,
Laura Petersilie2,
Gizem Inak1,4,
Carmen Menacho-Pando1,
Karl W. Kafitz2,
Agnieszka Rybak-Wolf3,
Nikolaus Rajewsky3,
Christine R. Rose2,
Alessandro Prigione1,5
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University,
2Institute of Neurobiology, Heinrich Heine University,
3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC),
4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai,
5, Max Delbrueck Center for Molecular Medicine (MDC)
Janna Leiz*,1,2,
Christian Hinze*,1,2,
Anastasiya Boltengagen3,
Caroline Braeuning4,
Christine Kocks3,
Nikolaus Rajewsky3,
Kai M. Schmidt-Ott1,2
1Department of Nephrology and Medical Intensive Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
2Molecular and Translational Kidney Research, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC),
3Berlin Institute of Medical Systems Biology (BIMSB), Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC),
4Berlin Institute of Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
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