Bonnie F. Sloane

Cathepsin B and D are Localized at the Surface of Human Breast Cancer Cells.

Analysis of a truncated form of cathepsin H in human prostate tumor cells.

Evidence for the involvement of cathepsin B in skeletal myoblast differentiation.

Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.

Interaction of human breast fibroblasts with collagen I increases secretion of procathepsin B.

Selective inhibition of cathepsin B with cell-permeable CA074Me negatively affects L6 rat myoblast differentiation.

Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.

Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.

Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene expression during human myoblast differentiation.

Cell-surface cathepsin B: understanding its functional significance.

Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors.

Pericellular cathepsin B and malignant progression.

Molecular regulation of human cathepsin B: implication in pathologies.

Cathepsin B and its role(s) in cancer progression.

Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.

Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site.

Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells.

Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.

Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents.

Isolation of a novel USF2 isoform: repressor of cathepsin B expression.

Cystatin m: a novel candidate tumor suppressor gene for breast cancer.

Cysteine cathepsins in human cancer.

Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment.

Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1.

Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.

Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.

Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.

High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.

Functional imaging of tumor proteolysis.

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH.

Cathepsin L splice variants in human breast cell lines.

Loss of caspase-8 in tumor cells: mechanism to overcome integrin-mediated death?

Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.

Cysteine cathepsins: multifunctional enzymes in cancer.

I2 imaging: cancer biology and the tumor microenvironment.

Functional expression of recombinant human stefin A in mammalian and bacterial cells.

Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment.

Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B.

Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function.

Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.

p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.

Visualizing protease activity in living cells: from two dimensions to four dimensions.

Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer.

Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts.

Imaging and quantifying the dynamics of tumor-associated proteolysis.

Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker.

Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells.

Bicarbonate increases tumor pH and inhibits spontaneous metastases.

Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation.

Microarrays for protease detection in tissues and cells.

Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis.

Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ.

Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation.

Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes.

Capturing and characterizing immune cells from breast tumor microenvironment: an innovative surgical approach.

Cathepsin B: a potential prognostic marker for inflammatory breast cancer.

Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin.

Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment.

Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.

Cathepsin B inhibition limits bone metastasis in breast cancer.

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer.