Department of Psychiatry,
Carver College of Medicine,
Iowa Neuroscience Institute,
Pappajohn Biomedical Institute
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Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
The Biochemical journal Feb, 2002 | Pubmed ID: 11802773
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2002 | Pubmed ID: 11854527
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
Neuron Apr, 2002 | Pubmed ID: 11988176
cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2003 | Pubmed ID: 12578970
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2003 | Pubmed ID: 12843249
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.
Pain Dec, 2003 | Pubmed ID: 14659506
Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14960591
Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.
Headache Oct, 2020 | Pubmed ID: 32750230
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 14988500
Impaired motor performance and learning in glia maturation factor-knockout mice.
Brain research Oct, 2004 | Pubmed ID: 15451385
Stomatin modulates gating of acid-sensing ion channels.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15471860
Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2005 | Pubmed ID: 16221840
Acid-sensing ion channels: advances, questions and therapeutic opportunities.
Trends in neurosciences Oct, 2006 | Pubmed ID: 16891000
Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2006 | Pubmed ID: 17060608
Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit.
Biological psychiatry Nov, 2007 | Pubmed ID: 17662962
Seizure termination by acidosis depends on ASIC1a.
Nature neuroscience Jul, 2008 | Pubmed ID: 18536711
The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19028690
Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2008 | Pubmed ID: 19091964
Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19218436
Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2009 | Pubmed ID: 19403806
Stereotactic atlas-based depth electrode localization in the human amygdala.
Stereotactic and functional neurosurgery , 2009 | Pubmed ID: 19556831
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2009 | Pubmed ID: 19587287
Acid-sensing ion channels: A new target for pain and CNS diseases.
Current opinion in drug discovery & development Sep, 2009 | Pubmed ID: 19736627
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.
Cell Nov, 2009 | Pubmed ID: 19945383
ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury.
The journal of pain Mar, 2010 | Pubmed ID: 20015700
Amygdala volume correlates positively with fearfulness in normal healthy girls.
Social cognitive and affective neuroscience Dec, 2010 | Pubmed ID: 20150341
Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice.
Pediatric research May, 2011 | Pubmed ID: 21258265
Histologic examination of the eye of acid-sensing ion channel 1a knockout mice.
International journal of physiology, pathophysiology and pharmacology Mar, 2010 | Pubmed ID: 21383900
Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice.
Clinical science (London, England : 1979) Nov, 2011 | Pubmed ID: 21615331
Neurobiology of panic and pH chemosensation in the brain.
Dialogues in clinical neuroscience , 2011 | Pubmed ID: 22275852
Detecting activity-evoked pH changes in human brain.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22566645
Fear and panic in humans with bilateral amygdala damage.
Nature neuroscience Mar, 2013 | Pubmed ID: 23377128
Acid-sensing ion channels in pain and disease.
Nature reviews. Neuroscience Jul, 2013 | Pubmed ID: 23783197
Functional t1ρ imaging in panic disorder.
Biological psychiatry Jun, 2014 | Pubmed ID: 24157339
Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.
Genes, brain, and behavior Feb, 2014 | Pubmed ID: 24256442
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
PloS one , 2013 | Pubmed ID: 24312498
Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice.
American journal of physiology. Cell physiology Feb, 2014 | Pubmed ID: 24336653
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2014 | Pubmed ID: 24421401
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.
Nature neuroscience Jun, 2014 | Pubmed ID: 24952644
Drug abuse and the simplest neurotransmitter.
ACS chemical neuroscience Sep, 2014 | Pubmed ID: 25054738
The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2014 | Pubmed ID: 25080586
Rapid acquisition strategy for functional T1ρ mapping of the brain.
Magnetic resonance imaging Nov, 2014 | Pubmed ID: 25093630
Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.
Molecular psychiatry Feb, 2015 | Pubmed ID: 25560762
Eccentricity mapping of the human visual cortex to evaluate temporal dynamics of functional T1ρ mapping.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jul, 2015 | Pubmed ID: 25966957
Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2015 | Pubmed ID: 26180203
ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing.
Frontiers in neuroscience , 2015 | Pubmed ID: 26257596
Peripheral inflammation during abnormal mood states in bipolar I disorder.
Journal of affective disorders Nov, 2015 | Pubmed ID: 26339927
Extinction of Cocaine Seeking Requires a Window of Infralimbic Pyramidal Neuron Activity after Unreinforced Lever Presses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 06, 2017 | Pubmed ID: 28539416
Transient acidosis while retrieving a fear-related memory enhances its lability.
eLife 06, 2017 | Pubmed ID: 28650315
Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.
Brain imaging and behavior Jun, 2018 | Pubmed ID: 28674759
Relationship altered between functional T1ρ and BOLD signals in bipolar disorder.
Brain and behavior 10, 2017 | Pubmed ID: 29075562
Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.
Bipolar disorders 06, 2018 | Pubmed ID: 29316081
Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins.
Psychopharmacology Jan, 2019 | Pubmed ID: 30003306
A novel role for acid-sensing ion channels in Pavlovian reward conditioning.
Genes, brain, and behavior 09, 2019 | Pubmed ID: 30375184
Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior.
Addiction biology 03, 2020 | Pubmed ID: 30397978
Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.
Circulation research 10, 2019 | Pubmed ID: 31451088
Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium.
Journal of neuroscience research 11, 2019 | Pubmed ID: 31452242
The amygdala differentially regulates defensive behaviors evoked by CO.
Behavioural brain research 01, 2020 | Pubmed ID: 31536735
A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy.
JCI insight 03, 2020 | Pubmed ID: 32163374
Comparison of TRho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study.
The Journal of neuropsychiatry and clinical neurosciences , 2020 | Pubmed ID: 32283991
Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.
Frontiers in psychiatry , 2020 | Pubmed ID: 33192650
A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment.
PLoS genetics 04, 2021 | Pubmed ID: 33886537
Post-acquisition CO Inhalation Enhances Fear Memory and Depends on ASIC1A.
Frontiers in behavioral neuroscience , 2021 | Pubmed ID: 34776896
Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study.
Cerebellum (London, England) May, 2022 | Pubmed ID: 35568792
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