Ola Didrik Saugstad

Prolonged apneas and hypoxia mediated by nicotine and endotoxin in piglets.

Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia.

Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia.

Maternal health in sudden intrauterine unexplained death: do urinary tract infections protect the fetus?

Bronchopulmonary dysplasia-oxidative stress and antioxidants.

Optimal oxygen therapy in the newborn period.

The role of oxygen in neonatal resuscitation.

Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis.

Effect of interleukin-10 on newborn piglet brain following hypoxia-ischemia and endotoxin-induced inflammation.

Room air resuscitation-two decades of neonatal research.

Oxygen for newborns: how much is too much?

Do negative life experiences predict the health-care-seeking of adolescents? A study of 10th-year students in Oslo, Norway.

Positive factors associated with promoting health in low-risk and high-risk populations of 15- and 16-year-old pupils in Oslo, Norway.

Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B.

Oxidative stress in the newborn--a 30-year perspective.

When newborn infants are bound to die.

Non-selective fetal reduction is malpractice.

New guidelines for newborn resuscitation.

Take a breath--but do not add oxygen (if not needed).

Optimal oxygenation at birth and in the neonatal period.

Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine.

Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation.

Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis.

Nicotine in a small-to-moderate dose does not cause a significant increase in plasma catecholamine levels in newborn piglets.

Effects of nicotine infusion on striatal glutamate and cortical non-protein-bound iron in hypoxic newborn piglets.

Albumin lavage does not improve the outcome of meconium aspiration syndrome.

Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation.

Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets.

Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes.

Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation.

Resuscitation of newborn infants: from oxygen to room air.

Ejection time-corrected systolic velocity improves accuracy in the evaluation of myocardial dysfunction: a study in piglets.

Oxygen and oxidative stress in bronchopulmonary dysplasia.

Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia.

Reducing global neonatal mortality is possible.

In search of the optimal oxygen saturation for extremely low birth weight infants: a systematic review and meta-analysis.

Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.

A time to be born and a time to die: ethical challenges in the neonatal intensive care unit.

How does the duration of active pushing in labor affect neonatal outcomes?

Hyperoxia in the term newborn: more evidence is still needed for optimal oxygen therapy.

Neurodevelopmental outcome of infants resuscitated with air or 100% oxygen: a systematic review and meta-analysis.

Resuscitation with supplementary oxygen induces oxidative injury in the cerebral cortex.

Oxygenation of the newborn: a molecular approach.

Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice.

Impact of antenatal glucocorticosteroids on whole-genome expression in preterm babies.

The oxygen paradox in the newborn: keep oxygen at normal levels.

Optimal oxygenation of extremely low birth weight infants: a meta-analysis and systematic review of the oxygen saturation target studies.

Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome.

Hypoxia-reoxygenation affects whole-genome expression in the newborn eye.

Chorioamnionitis as a risk factor for retinopathy of prematurity: a systematic review and meta-analysis.

Physical activity and the risk of preeclampsia: a systematic review and meta-analysis.

Systematic review and meta-analysis of optimal initial fraction of oxygen levels in the delivery room at ≤32 weeks.

Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis.

New growth charts for newborn babies.

Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation.

Delivery room management of term and preterm newly born infants.

Hyperoxia and cerebral vasoconstriction in healthy newborns.

50 Years Ago in The Journal of Pediatrics: Arterial Blood Gas Tensions and Acid-Base Balance in the Management of Respiratory Distress Syndrome.

Saving Newborn Babies - The Benefits of Interventions in Neonatal Care in Norway over More Than 40 Years.

Why did the authors perform a meta-analysis of studies with primary endpoints they consider clinically unimportant?

Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air.

A critical review of the 2015 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant.

Assessing Heart Rate at Birth: Auscultation Is Still the Gold Standard.

Children's Right to Health: Implications for Decision-Making in Newborn Medical Care.

50 Years Ago in TheJournal ofPediatrics: Alkali Therapy in the Delivery Room.

Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.

Physical activity and the risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of epidemiological studies.

N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia.

Temporal Patterns of Gene Expression Profiles in the Neonatal Mouse Lung after Hypoxia-Reoxygenation.

50 Years Ago in TheJournal ofPediatrics: Arterial Oxygen Tension in Premature Infants.

The Newborn at the edge of viability.

50 Years Ago in TheJournal ofPediatrics: Acetylcholine in the Treatment of Idiopathic Respiratory Distress Syndrome.

50 Years Ago in The Journal of Pediatrics: The Incidence of Neonatal Hypoglycemia-A Completed Survey.

Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.

DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets.

Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.

50 Years Ago in The Journal of Pediatrics: Feeding Studies in Low-Birth-Weight Infants.

50 Years Ago in The Journal of Pediatrics: Effects of Hypoxemia, Hypercarbia, Acidosis, and Reduced Pulmonary Blood Flow on the Surfactant Fetal Lamb Lung.

Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants.

50 Years Ago in The Journal of Pediatrics: Phenylketonuria: Evaluation of Therapy and Verification of Diagnosis.

50 Years Ago in The Journal of Pediatrics: Alveolar Arterial Oxygen Gradient in Premature Infants Breathing 100% Oxygen.

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.

50 Years Ago in The Journal of Pediatrics: The Effect of Pretreatment with Pentobarbital, Meperidine, or Hyperbaric Oxygen on the Response to Anoxia and Resuscitation in Newborn Rabbits.

Kynurenine Pathway in Autism Spectrum Disorders in Children.

Hyperoxia induces epigenetic changes in newborn mice lungs.

50 Years Ago in The Journal of Pediatrics: Birth Weight, Gestational Age, and Sex as Determining Factors in the Incidence of Respiratory Distress Syndrome of Prematurely Born Infants.

When Helping Babies Breathe Is Not Enough: Designing a Novel, Mid-Level Neonatal Resuscitation Algorithm for Médecins Sans Frontières Field Teams Working in Low-Resource Hospital Settings.

Oxygen Treatment for Immature Infants beyond the Delivery Room: Lessons from Randomized Studies.

Role of the Immune System in Autism Spectrum Disorders (ASD).

Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation.

Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.

DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers.

Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets.

Navigating a Mid-Level Gap in Neonatal Resuscitation.

50 Years Ago in The Journal Of Pediatrics: Sudden Unexpected Death in Infancy: A Statistical Analysis of Certain Socioeconomic Factors.

NICU Dialects: Understanding Norwegian Practice Variation.

50 Years Ago in The Journal of Pediatrics: Uric Acid Levels in Full-Term and Low-Birth-Weight Infants.

Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.

Oxygen therapy of the newborn from molecular understanding to clinical practice.

Reply.

Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia.

50 Years Ago in The Journal Of Pediatrics: A New Disorder of Purine Metabolism with Behavioral Manifestations.

A comparison of DNA methylation in newborn blood samples from infants with and without orofacial clefts.

50 Years Ago in The Journal of Pediatrics: The Use of Acid-Base Measurements in the Clinical Evaluation and Treatment of the Sick Neonate.

50 Years Ago in The Journal of Pediatrics: Acid-Base Monitoring of the Fetus during Labor with Blood Obtained from the Scalp.

50 Years Ago in TheJournal ofPediatrics: Intrauterine Growth of Live-Born Caucasian Infants at Sea Level: Standards Obtained from Measurements in 7 Dimensions of Infants Born between 25 and 44 Weeks of Gestation.

Targeting Oxygen in Term and Preterm Infants Starting at Birth.

The oxygen dilemma: oxygen saturation targets in preterm infants.

50 Years Ago in TheJournal ofPediatrics: Lung Expansion and Ventilation During Resuscitation of Asphyxiated Newborn Infants.

50 Years Ago in The Journal ofPediatrics: The Effect of Pentobarbital Anesthesia on Resuscitation and Brain Damage in Fetal Rhesus Monkeys Asphyxiated on Delivery.

Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy.

Finally, A Tool to Address Extubation Anxiety!

50 Years Ago in TheJournal ofPediatrics: Polycythemia in Small for Gestational Age Infants.

Placental Weight and Risk of Neonatal Death.

50 Years Ago in TheJournal ofPediatrics: Human Chromosomal Deletion: Two Patients with the 4p-Syndrome.

Myalgic Encephalomyelitis (ME) in the Young. Time to Repent.

Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia.

What did I learn as a neonatologist over 40 years and what impact did Napoleon have on modern newborn medicine?

Oxygen metabolism and oxygenation of the newborn.

50 Years Ago in TheJournal ofPediatrics: Positive Pressure Ventilation in the Newborn Infant: The Use of a Face Mask.

Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity.

50 Years Ago in TheJournalofPediatrics: Chromosome Studies in Full Term, Low Birth Weight, Mentally Retarded Patients.

50 Years Ago in TheJournalofPediatrics: When the Lung Ruptures - 50 Years Ago and Today.

50 Years Ago in TheJournalofPediatrics: Birth Weight Is More Important than Gestational Age for Long-Term Intellectual Outcome.

50 Years Ago in TheJournalofPediatrics: Developmental Outcome for Trisomy 21 Mosaicism.

More Details Needed on Association of Placental Weight With Risk of Neonatal Death-Reply.

50 Years Ago in The Journal of Pediatrics: Wilson-Mikity Syndrome.

Acetaminophen and the Developing Brain: Reason for Concern?

50 Years Ago in TheJournalofPediatrics: Light Exposure to the Immature Eye.

50 Years Ago in The Journal of Pediatrics: When the Newborn Remains Blue.

50 Years Ago in The Journal of Pediatrics: Neonatal Seizures: 50 Years of Progress.

50 Years Ago in The Journal of Pediatrics: Neonatal Seizures: 50 Years of Progress.

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates.

Reply.

50 Years Ago in TheJournalofPediatrics: Umbilical Catheters-Then and Now.

50 Years Ago in TheJournalofPediatrics: Magnesium and Birth Asphyxia.

50 Years Ago in TheJournalofPediatrics: The Oxygen-Hemoglobin Equilibrium Curve and Tissue Oxygen Release.

50 Years Ago in TheJournalofPediatrics: The Newborn Electrocardiogram.

50 Years Ago in TheJournalofPediatrics: Diagnostic Utility of the Newborn Electrocardiogram.

50 Years Ago in TheJournalofPediatrics: Hepatopulmonary Syndrome: Transplantation Is the Big Difference.

50 Years Ago in TheJournalofPediatrics: Sixth Cranial Nerve Palsy in the Neonate.

50 Years Ago in TheJournalofPediatrics: Vigorous and Repeated Nasopharyngeal Suctioning.

Oxygen saturation (SpO2) targeting for newborn infants at delivery: Are we reaching for an impossible unknown?

50 Years Ago in TheJournalofPediatrics: The Oxygen Dilemma.

Potential Value of Maternal Oxygen Supplementation.

Oxygen in the First Minutes of Life in Very Preterm Infants.

50 Years Ago in TheJournalofPediatrics: Pregnancy in Women with Galactosemia.

Newborns at risk of Covid-19 - lessons from the last year.

50 Years Ago in TheJournalofPediatrics: Neonatal Anemia Prevention and Treatment.

50 Years Ago in TheJournalofPediatrics: Neonatal Platelet Aggregation: Effects of Antenatal Aspirin.

50 Years Ago in TheJournalofPediatrics: Noninvasive Blood Pressure Measurement in Neonates.

50 Years Ago in TheJournalofPediatrics: Fetal Heart Rate Patterns and Umbilical Cord Base Deficit.

50 Years Ago in TheJournalofPediatrics: Neonatal Herpes Virus Infection in the Preacyclovir Era.

50 Years Ago in TheJournalofPediatrics: Diagnosis of Self-Mutilation and Hyperuricemia.

50 Years Ago in TheJournalofPediatrics: Early-Onset Neonatal Sepsis.

Neurodevelopmental outcomes of preterm infants after randomisation to initial resuscitation with lower (FiO 0.3) or higher (FiO 0.6) initial oxygen levels. An individual patient meta-analysis.

50 Years Ago in TheJournalofPediatrics: Wolf-Hirschorn Versus Cri-du-Chat Syndrome.

50 Years Ago in TheJournalofPediatrics: Maternal Cytomegalovirus Infection.

50 Years Ago in TheJournalofPediatrics: Hemiallogeneic Stem Cell Transplantation-from Last Resort to a Viable Treatment Option.

50 Years Ago in TheJournalofPediatrics: Birth Weight Versus Gestational Age as Outcome Predictors.

50 Years Ago in TheJournalofPediatrics: Fatal Genetic Newborn Lung Disease.

50 Years Ago in TheJournalofPediatrics: Recoarctation of the Aorta.

50 Years Ago in TheJournalofPediatrics: Umbilical Arterial Catheter and Umbilical Vessel Catheterization Use and Complications.

50 Years Ago in TheJournalofPediatrics: Iron Supplementation in Infants Born at Term.

Oxygenation of the newborn. The impact of one molecule on newborn lives.

Is the increasing prevalence of labor induction accompanied by changes in pregnancy outcomes? An observational study of all singleton births at gestational weeks 37-42 in Norway during 1999-2019.

Microbial DNA extraction of high-host content and low biomass samples: Optimized protocol for nasopharynx metagenomic studies.