Department of Immunology
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Differential role of the NLRP3 inflammasome in infection and tumorigenesis.
Immunology Apr, 2019 | Pubmed ID: 30666624
The role of inflammasome modulation in virulence.
Virulence May, 2012 | Pubmed ID: 22546900
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.
Nature Aug, 2012 | Pubmed ID: 22763455
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.
PLoS pathogens , 2012 | Pubmed ID: 22807671
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22898816
IL-1 family cytokines trigger sterile inflammatory disease.
Frontiers in immunology , 2012 | Pubmed ID: 23087690
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.
Arthritis research & therapy Nov, 2012 | Pubmed ID: 23148704
Innate immune pathways in host defense.
Mediators of inflammation , 2012 | Pubmed ID: 23326019
Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β).
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23386602
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Nature immunology May, 2013 | Pubmed ID: 23525089
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Nature Jun, 2013 | Pubmed ID: 23708968
NLRP6 in infection and inflammation.
Microbes and infection , 2013 | Pubmed ID: 23811097
The expanding role of NLRs in antiviral immunity.
Immunological reviews Sep, 2013 | Pubmed ID: 23947344
Unsolved Mysteries in NLR Biology.
Frontiers in immunology Sep, 2013 | Pubmed ID: 24062750
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.
Frontiers in cellular and infection microbiology , 2013 | Pubmed ID: 24273750
Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24347638
Critical role for inflammasome-independent IL-1β production in osteomyelitis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24395792
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2014 | Pubmed ID: 24453255
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Nature communications , 2014 | Pubmed ID: 24492532
Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.
PLoS pathogens Apr, 2014 | Pubmed ID: 24722226
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Cell May, 2014 | Pubmed ID: 24813850
Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.
Seminars in immunopathology Sep, 2014 | Pubmed ID: 24838628
Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis.
Mucosal immunology Nov, 2014 | Pubmed ID: 24850431
Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection.
Journal of virology Aug, 2014 | Pubmed ID: 24872587
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Nature Aug, 2014 | Pubmed ID: 25043000
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection.
PLoS pathogens Sep, 2014 | Pubmed ID: 25254654
Dietary modulation of the microbiome affects autoinflammatory disease.
Nature Dec, 2014 | Pubmed ID: 25274309
Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2014 | Pubmed ID: 25320273
Novel roles for caspase-8 in IL-1β and inflammasome regulation.
The American journal of pathology Jan, 2015 | Pubmed ID: 25451151
Mitochondria: diversity in the regulation of the NLRP3 inflammasome.
Trends in molecular medicine Mar, 2015 | Pubmed ID: 25500014
Drak2 is not required for tumor surveillance and suppression.
International immunology Mar, 2015 | Pubmed ID: 25568303
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25605939
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.
The Journal of clinical investigation Feb, 2015 | Pubmed ID: 25607842
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.
Nature communications Jan, 2015 | Pubmed ID: 25607885
Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2015 | Pubmed ID: 25637014
An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis.
The Journal of clinical investigation Mar, 2015 | Pubmed ID: 25689249
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.
Cell host & microbe Mar, 2015 | Pubmed ID: 25704009
Inflammasome control of viral infection.
Current opinion in virology Jun, 2015 | Pubmed ID: 25771504
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
Nature immunology May, 2015 | Pubmed ID: 25774715
The inflammasome: firing up innate immunity.
Immunological reviews May, 2015 | Pubmed ID: 25879279
Regulation of inflammasome activation.
Immunological reviews May, 2015 | Pubmed ID: 25879280
The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.
Immunity Apr, 2015 | Pubmed ID: 25888258
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Nature genetics Jun, 2015 | Pubmed ID: 25938942
A20 is a regulator of necroptosis.
Nature immunology Jun, 2015 | Pubmed ID: 25988900
Innate immune recognition of mtDNA--an undercover signal?
Cell metabolism Jun, 2015 | Pubmed ID: 26039443
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.
Cell Jul, 2015 | Pubmed ID: 26095253
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.
Nature cell biology Jul, 2015 | Pubmed ID: 26098576
Innate immunity against Leishmania infections.
Cellular microbiology Sep, 2015 | Pubmed ID: 26249747
NLRP12 in autoimmune diseases.
Oncotarget Aug, 2015 | Pubmed ID: 26343520
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.
Scientific reports Sep, 2015 | Pubmed ID: 26412089
Gasdermin D: the long-awaited executioner of pyroptosis.
Cell research Nov, 2015 | Pubmed ID: 26482951
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity.
European journal of immunology Feb, 2016 | Pubmed ID: 26626159
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
Nature reviews. Immunology Jan, 2016 | Pubmed ID: 26655628
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Type I Interferon Keeps IL-1β in Check.
Cell host & microbe Mar, 2016 | Pubmed ID: 26962937
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology 01, 2017 | Pubmed ID: 27007676
Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.
Cellular and molecular life sciences : CMLS Aug, 2016 | Pubmed ID: 27032699
DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.
Pathogens and disease Jun, 2016 | Pubmed ID: 27056948
NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2016 | Pubmed ID: 27071119
Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi.
Journal of leukocyte biology Sep, 2016 | Pubmed ID: 27101991
Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease.
Gut microbes Jul, 2016 | Pubmed ID: 27148834
Autoinflammatory Skin Disorders: The Inflammasomme in Focus.
Trends in molecular medicine Jul, 2016 | Pubmed ID: 27267764
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.
Scientific reports Jun, 2016 | Pubmed ID: 27291827
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.
The Journal of cell biology Jun, 2016 | Pubmed ID: 27325789
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.
Journal of leukocyte biology Jan, 2017 | Pubmed ID: 27418355
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
The Journal of experimental medicine Sep, 2016 | Pubmed ID: 27551156
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.
European journal of immunology Nov, 2016 | Pubmed ID: 27624090
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Cell Oct, 2016 | Pubmed ID: 27693356
IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis.
The Journal of clinical investigation Dec, 2016 | Pubmed ID: 27775548
Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.
Autophagy Dec, 2016 | Pubmed ID: 27786577
Distinct role of IL-1β in instigating disease in Sharpin mice.
Scientific reports Nov, 2016 | Pubmed ID: 27892465
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Science immunology Aug, 2016 | Pubmed ID: 27917412
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature Dec, 2016 | Pubmed ID: 27951586
IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.
The American journal of pathology Feb, 2017 | Pubmed ID: 27998728
Inflammasomes and Cancer.
Cancer immunology research Feb, 2017 | Pubmed ID: 28093447
Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2017 | Pubmed ID: 28130494
Regulation and functions of NLRP3 inflammasome during influenza virus infection.
Molecular immunology Jun, 2017 | Pubmed ID: 28169000
Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Scientific reports Mar, 2017 | Pubmed ID: 28345580
Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?
The FEBS journal Aug, 2017 | Pubmed ID: 28374568
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Immunity Apr, 2017 | Pubmed ID: 28410990
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.
Immunological reviews May, 2017 | Pubmed ID: 28462526
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2017 | Pubmed ID: 28468974
Mechanisms governing inflammasome activation, assembly and pyroptosis induction.
International immunology May, 2017 | Pubmed ID: 28531279
NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.
Cell cycle (Georgetown, Tex.) Jul, 2017 | Pubmed ID: 28598238
Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance.
Journal of virology Sep, 2017 | Pubmed ID: 28615208
ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.
The Journal of experimental medicine Aug, 2017 | Pubmed ID: 28634194
War on Viruses: LC3 Recruits GTPases.
Cell host & microbe Jul, 2017 | Pubmed ID: 28704655
Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.
Infection and immunity Oct, 2017 | Pubmed ID: 28784930
Inflammatory Bowel Disease and the NLRP3 Inflammasome.
The New England journal of medicine Aug, 2017 | Pubmed ID: 28813221
Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.
Scientific reports Sep, 2017 | Pubmed ID: 28904353
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2017 | Pubmed ID: 28947539
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
mBio Oct, 2017 | Pubmed ID: 28974614
Inflammatory cell death in intestinal pathologies.
Immunological reviews Nov, 2017 | Pubmed ID: 29027223
Recent advances in inflammasome biology.
Current opinion in immunology Feb, 2018 | Pubmed ID: 29128729
cGAMP: A tale of two signals.
The Journal of experimental medicine Dec, 2017 | Pubmed ID: 29150429
Inflammasome activation and assembly at a glance.
Journal of cell science Dec, 2017 | Pubmed ID: 29196474
Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.
Gastroenterology Mar, 2018 | Pubmed ID: 29203393
Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2018 | Pubmed ID: 29203515
ZBP1: Innate Sensor Regulating Cell Death and Inflammation.
Trends in immunology Feb, 2018 | Pubmed ID: 29236673
Mechanisms and Consequences of Inflammasome Activation.
Journal of molecular biology Jan, 2018 | Pubmed ID: 29247654
Function and regulation of IL-1α in inflammatory diseases and cancer.
Immunological reviews Jan, 2018 | Pubmed ID: 29247991
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Cell reports Dec, 2017 | Pubmed ID: 29262324
IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2018 | Pubmed ID: 29321274
The Absence of NOD1 Enhances Killing of Through Modulation of Dectin-1 Expression.
Frontiers in immunology , 2017 | Pubmed ID: 29326692
Gasdermin D Flashes an Exit Signal for IL-1.
Immunity Jan, 2018 | Pubmed ID: 29343431
Stressed-out ROS take a silent death route.
Nature immunology Feb, 2018 | Pubmed ID: 29348507
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
The American journal of pathology Apr, 2018 | Pubmed ID: 29353059
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.
The Journal of experimental medicine Apr, 2018 | Pubmed ID: 29500178
Food for Training-Western Diet and Inflammatory Memory.
Cell metabolism Mar, 2018 | Pubmed ID: 29514058
Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.
Cell reports Mar, 2018 | Pubmed ID: 29562174
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Cell May, 2018 | Pubmed ID: 29576451
ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.
The Journal of clinical investigation May, 2018 | Pubmed ID: 29629899
The inflammasome starts rolling.
Nature reviews. Immunology Aug, 2018 | Pubmed ID: 29858587
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.
Immunity Jul, 2018 | Pubmed ID: 29958799
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.
Nature communications Jul, 2018 | Pubmed ID: 29980664
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.
Cell death and differentiation Mar, 2019 | Pubmed ID: 30038386
Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative .
Cell death discovery , 2018 | Pubmed ID: 30062052
Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2018 | Pubmed ID: 30082320
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.
Immunity Sep, 2018 | Pubmed ID: 30170813
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.
Immunity Sep, 2018 | Pubmed ID: 30231985
Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.
PLoS biology Nov, 2018 | Pubmed ID: 30388107
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against .
Journal of immunology (Baltimore, Md. : 1950) Dec, 2018 | Pubmed ID: 30404813
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.
The Journal of clinical investigation Jan, 2019 | Pubmed ID: 30457980
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.
Nature microbiology Feb, 2019 | Pubmed ID: 30510167
Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?
Circulation Dec, 2018 | Pubmed ID: 30571276
The signposts and winding roads to immunity and inflammation.
Nature reviews. Immunology Feb, 2019 | Pubmed ID: 30602731
Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.
Nature materials Mar, 2019 | Pubmed ID: 30664693
Fueling Ketone Metabolism Quenches Salt-Induced Hypertension.
Trends in endocrinology and metabolism: TEM Mar, 2019 | Pubmed ID: 30670332
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports Jan, 2019 | Pubmed ID: 30673616
Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.
PloS one , 2019 | Pubmed ID: 30794604
Diverging inflammasome signals in tumorigenesis and potential targeting.
Nature reviews. Cancer Apr, 2019 | Pubmed ID: 30842595
On the Road to Discovering the Elusive Executioner of Pyroptosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2019 | Pubmed ID: 30885986
Cell death-mediated cytokine release and its therapeutic implications.
The Journal of experimental medicine Jul, 2019 | Pubmed ID: 31186281
The NLRC4 inflammasome requires IRF8-dependent production of NAIPs.
Cell stress May, 2018 | Pubmed ID: 31225480
Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.
European journal of immunology Nov, 2019 | Pubmed ID: 31372985
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Nature Sep, 2019 | Pubmed ID: 31511697
Inflammasomes in the pathophysiology of autoinflammatory syndromes.
Journal of leukocyte biology Mar, 2020 | Pubmed ID: 31608507
Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.
Journal of virology Jan, 2020 | Pubmed ID: 31694942
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
The Journal of biological chemistry Mar, 2020 | Pubmed ID: 31719149
Hidden Aspects of Valency in Immune System Regulation.
Trends in immunology Dec, 2019 | Pubmed ID: 31734148
Targeting Apoptosis Inhibition to Activate Antitumor Immunity.
Trends in immunology Dec, 2019 | Pubmed ID: 31735511
Inflammasomes and the fine line between defense and disease.
Current opinion in immunology Feb, 2020 | Pubmed ID: 31837596
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis).
Frontiers in cellular and infection microbiology , 2019 | Pubmed ID: 31850239
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease.
The Journal of experimental medicine Mar, 2020 | Pubmed ID: 31869420
Pyroptosis in Antiviral Immunity.
Current topics in microbiology and immunology Dec, 2019 | Pubmed ID: 31875268
Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Inflammation Jun, 2020 | Pubmed ID: 32002713
Caspases in Cell Death, Inflammation, and Pyroptosis.
Annual review of immunology Apr, 2020 | Pubmed ID: 32017655
DNA Sensing in the Innate Immune Response.
Physiology (Bethesda, Md.) Mar, 2020 | Pubmed ID: 32027562
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
PLoS pathogens Mar, 2020 | Pubmed ID: 32150572
Toward targeting inflammasomes: insights into their regulation and activation.
Cell research Apr, 2020 | Pubmed ID: 32152420
Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.
Cellular & molecular immunology Jul, 2021 | Pubmed ID: 32203187
IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.
Journal of immunology (Baltimore, Md. : 1950) May, 2020 | Pubmed ID: 32205422
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Cell Apr, 2020 | Pubmed ID: 32298652
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.
The Journal of biological chemistry Jun, 2020 | Pubmed ID: 32350114
DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells.
DNA and cell biology Jul, 2020 | Pubmed ID: 32397752
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Immunity Jun, 2020 | Pubmed ID: 32428502
Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).
Frontiers in cellular and infection microbiology , 2020 | Pubmed ID: 32547960
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Developmental cell Aug, 2020 | Pubmed ID: 32553121
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.
JCI insight Jun, 2020 | Pubmed ID: 32554929
PANoptosis components, regulation, and implications.
Aging Jun, 2020 | Pubmed ID: 32575071
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).
Frontiers in cellular and infection microbiology , 2020 | Pubmed ID: 32582562
ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease.
The Journal of experimental medicine Jul, 2020 | Pubmed ID: 32584411
The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis).
Immunological reviews Sep, 2020 | Pubmed ID: 32729116
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
The Journal of biological chemistry Oct, 2020 | Pubmed ID: 32763970
PANoptosis in microbial infection.
Current opinion in microbiology Feb, 2021 | Pubmed ID: 32829024
NLRP12 in innate immunity and inflammation.
Molecular aspects of medicine Dec, 2020 | Pubmed ID: 32838963
Intracellular innate immune receptors: Life inside the cell.
Immunological reviews Sep, 2020 | Pubmed ID: 32856334
A comprehensive guide to studying inflammasome activation and cell death.
Nature protocols Oct, 2020 | Pubmed ID: 32895525
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles.
Trends in molecular medicine Nov, 2020 | Pubmed ID: 32948447
Acute IL-4 Governs Pathogenic T Cell Responses during Infection.
ImmunoHorizons Sep, 2020 | Pubmed ID: 32948646
RIPK3 Promotes Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2020 | Pubmed ID: 32989095
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).
The Journal of biological chemistry Dec, 2020 | Pubmed ID: 33109609
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
bioRxiv : the preprint server for biology Nov, 2020 | Pubmed ID: 33140051
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines.
Trends in immunology Dec, 2020 | Pubmed ID: 33153908
The innate immune system and cell death in autoinflammatory and autoimmune disease.
Current opinion in immunology Dec, 2020 | Pubmed ID: 33242752
Galactosaminogalactan activates the inflammasome to provide host protection.
Nature Dec, 2020 | Pubmed ID: 33268895
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell Jan, 2021 | Pubmed ID: 33278357
RIPK1 Distinctly Regulates -Induced Inflammatory Cell Death, PANoptosis.
ImmunoHorizons Dec, 2020 | Pubmed ID: 33310881
Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection.
Nature Jan, 2021 | Pubmed ID: 33349706
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.
Journal of cellular immunology , 2020 | Pubmed ID: 33426542
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.
Nature communications Jan, 2021 | Pubmed ID: 33479228
Advances in Understanding Activation and Function of the NLRC4 Inflammasome.
International journal of molecular sciences Jan, 2021 | Pubmed ID: 33494299
Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease.
Signal transduction and targeted therapy Jan, 2021 | Pubmed ID: 33514689
A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma.
Cancer research May, 2021 | Pubmed ID: 33619117
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
Sepsis take-out: Inhibiting bacterial deliveries.
Immunity Mar, 2021 | Pubmed ID: 33691128
NLRP3 inflammasome in cancer and metabolic diseases.
Nature immunology May, 2021 | Pubmed ID: 33707781
Role of inflammasomes/pyroptosis and PANoptosis during fungal infection.
PLoS pathogens Mar, 2021 | Pubmed ID: 33735255
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
The Journal of biological chemistry , 2021 | Pubmed ID: 33766561
Intestinal tête-à-tête: helminths blunt immunity against flaviviruses.
Cell research Jul, 2021 | Pubmed ID: 33846568
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
Nature immunology Jul, 2021 | Pubmed ID: 33963333
CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes.
bioRxiv : the preprint server for biology Aug, 2021 | Pubmed ID: 34075382
TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2021 | Pubmed ID: 34145059
Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis.
mBio Jun, 2021 | Pubmed ID: 34154417
The 'cytokine storm': molecular mechanisms and therapeutic prospects.
Trends in immunology Aug, 2021 | Pubmed ID: 34217595
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons Jul, 2021 | Pubmed ID: 34290111
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Nature Sep, 2021 | Pubmed ID: 34471287
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.
Computational and structural biotechnology journal , 2021 | Pubmed ID: 34504660
PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field.
Journal of molecular biology Feb, 2022 | Pubmed ID: 34537233
Programming inflammatory cell death for therapy.
Pharmacology & therapeutics Apr, 2022 | Pubmed ID: 34619283
Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2021 | Pubmed ID: 34663620
NLRP3 inflammasome activation triggers gasdermin D-independent inflammation.
Science immunology Oct, 2021 | Pubmed ID: 34678046
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Cell reports Oct, 2021 | Pubmed ID: 34686350
The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice.
European journal of immunology Feb, 2022 | Pubmed ID: 34694641
Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections.
The Journal of biological chemistry Dec, 2021 | Pubmed ID: 34740613
Integrated stress response restricts macrophage necroptosis.
Life science alliance Jan, 2022 | Pubmed ID: 34764207
Fungal cell wall components modulate our immune system.
Cell surface (Amsterdam, Netherlands) Dec, 2021 | Pubmed ID: 34825116
It's just a phase: NLRP6 phase separations drive signaling.
Cell research Feb, 2022 | Pubmed ID: 34837058
Fostering experimental and computational synergy to modulate hyperinflammation.
Trends in immunology Jan, 2022 | Pubmed ID: 34844849
induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2022 | Pubmed ID: 34996874
Innate immunity: the first line of defense against SARS-CoV-2.
Nature immunology Feb, 2022 | Pubmed ID: 35105981
The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis.
Cancers Feb, 2022 | Pubmed ID: 35205671
NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis.
ImmunoHorizons Mar, 2022 | Pubmed ID: 35301258
It's All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects.
Cells Apr, 2022 | Pubmed ID: 35563804
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection.
Science immunology Aug, 2022 | Pubmed ID: 35587515
DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease.
Cells May, 2022 | Pubmed ID: 35626643
Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease.
Cells Jun, 2022 | Pubmed ID: 35741014
A BAF-fling connection to RIPK1.
Cell research Aug, 2022 | Pubmed ID: 35787662
Inflammasome signaling in colorectal cancer.
Translational research : the journal of laboratory and clinical medicine Feb, 2023 | Pubmed ID: 36150688
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.
Cellular and molecular life sciences : CMLS Sep, 2022 | Pubmed ID: 36169732
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
Cell reports Oct, 2022 | Pubmed ID: 36198273
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2022 | Pubmed ID: 36253067
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology.
NAR cancer Dec, 2022 | Pubmed ID: 36329783
Humans pIKK-up NLRP3 to skip NEK7.
Trends in immunology Dec, 2022 | Pubmed ID: 36404209
Innate immunity, cytokine storm, and inflammatory cell death in COVID-19.
Journal of translational medicine Nov, 2022 | Pubmed ID: 36419185
Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression.
Frontiers in immunology , 2022 | Pubmed ID: 36505497
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines.
Pathogens (Basel, Switzerland) Nov, 2022 | Pubmed ID: 36558734
AIM2 sensors mediate immunity to infection in hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2023 | Pubmed ID: 36595704
CD47 halts -deficient neutrophils from provoking lethal inflammation.
Science advances Jan, 2023 | Pubmed ID: 36608128
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