Thirumala-Devi Kanneganti

Differential role of the NLRP3 inflammasome in infection and tumorigenesis.

The role of inflammasome modulation in virulence.

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.

Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.

Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens.

IL-1 family cytokines trigger sterile inflammatory disease.

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.

Innate immune pathways in host defense.

Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β).

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

NLRP6 in infection and inflammation.

The expanding role of NLRs in antiviral immunity.

Unsolved Mysteries in NLR Biology.

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.

Critical role for inflammasome-independent IL-1β production in osteomyelitis.

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis.

Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection.

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection.

Dietary modulation of the microbiome affects autoinflammatory disease.

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.

Novel roles for caspase-8 in IL-1β and inflammasome regulation.

Mitochondria: diversity in the regulation of the NLRP3 inflammasome.

Drak2 is not required for tumor surveillance and suppression.

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.

Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation.

An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis.

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.

Inflammasome control of viral infection.

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

The inflammasome: firing up innate immunity.

Regulation of inflammasome activation.

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

A20 is a regulator of necroptosis.

Innate immune recognition of mtDNA--an undercover signal?

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.

Innate immunity against Leishmania infections.

NLRP12 in autoimmune diseases.

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.

Gasdermin D: the long-awaited executioner of pyroptosis.

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity.

Converging roles of caspases in inflammasome activation, cell death and innate immunity.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Type I Interferon Keeps IL-1β in Check.

Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.

Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.

DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis.

Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi.

Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease.

Autoinflammatory Skin Disorders: The Inflammasomme in Focus.

DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.

Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation.

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis.

Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B.

Distinct role of IL-1β in instigating disease in Sharpin mice.

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.

IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.

Inflammasomes and Cancer.

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.

Regulation and functions of NLRP3 inflammasome during influenza virus infection.

Differential roles of caspase-1 and caspase-11 in infection and inflammation.

Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.

Mechanisms governing inflammasome activation, assembly and pyroptosis induction.

NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.

Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance.

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.

War on Viruses: LC3 Recruits GTPases.

Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.

Inflammatory Bowel Disease and the NLRP3 Inflammasome.

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.

Inflammatory cell death in intestinal pathologies.

Recent advances in inflammasome biology.

cGAMP: A tale of two signals.

Inflammasome activation and assembly at a glance.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

ZBP1: Innate Sensor Regulating Cell Death and Inflammation.

Mechanisms and Consequences of Inflammasome Activation.

Function and regulation of IL-1α in inflammatory diseases and cancer.

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.

The Absence of NOD1 Enhances Killing of Through Modulation of Dectin-1 Expression.

Gasdermin D Flashes an Exit Signal for IL-1.

Stressed-out ROS take a silent death route.

ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

Food for Training-Western Diet and Inflammatory Memory.

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.

The inflammasome starts rolling.

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative .

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses.

Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against .

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?

The signposts and winding roads to immunity and inflammation.

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.

Fueling Ketone Metabolism Quenches Salt-Induced Hypertension.

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

Diverging inflammasome signals in tumorigenesis and potential targeting.

On the Road to Discovering the Elusive Executioner of Pyroptosis.

Cell death-mediated cytokine release and its therapeutic implications.

The NLRC4 inflammasome requires IRF8-dependent production of NAIPs.

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Inflammasomes in the pathophysiology of autoinflammatory syndromes.

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.

Hidden Aspects of Valency in Immune System Regulation.

Targeting Apoptosis Inhibition to Activate Antitumor Immunity.

Inflammasomes and the fine line between defense and disease.

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis).

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease.

Pyroptosis in Antiviral Immunity.

Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.

Caspases in Cell Death, Inflammation, and Pyroptosis.

DNA Sensing in the Innate Immune Response.

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

Toward targeting inflammasomes: insights into their regulation and activation.

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.

IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.

DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells.

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.

PANoptosis components, regulation, and implications.

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).

ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease.

The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis).

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.

PANoptosis in microbial infection.

NLRP12 in innate immunity and inflammation.

Intracellular innate immune receptors: Life inside the cell.

A comprehensive guide to studying inflammasome activation and cell death.

Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles.

Acute IL-4 Governs Pathogenic T Cell Responses during Infection.

RIPK3 Promotes Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines.

The innate immune system and cell death in autoinflammatory and autoimmune disease.

Galactosaminogalactan activates the inflammasome to provide host protection.

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

RIPK1 Distinctly Regulates -Induced Inflammatory Cell Death, PANoptosis.

Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection.

Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

Advances in Understanding Activation and Function of the NLRC4 Inflammasome.

Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease.

A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Sepsis take-out: Inhibiting bacterial deliveries.

NLRP3 inflammasome in cancer and metabolic diseases.

Role of inflammasomes/pyroptosis and PANoptosis during fungal infection.

DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.

Intestinal tête-à-tête: helminths blunt immunity against flaviviruses.

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.

CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes.

TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly.

Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis.

The 'cytokine storm': molecular mechanisms and therapeutic prospects.

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.

PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field.

Programming inflammatory cell death for therapy.

Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection.

NLRP3 inflammasome activation triggers gasdermin D-independent inflammation.

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice.

Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections.

Integrated stress response restricts macrophage necroptosis.

Fungal cell wall components modulate our immune system.

It's just a phase: NLRP6 phase separations drive signaling.

Fostering experimental and computational synergy to modulate hyperinflammation.

induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax.

Innate immunity: the first line of defense against SARS-CoV-2.

The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis.

NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis.

It's All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects.

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection.

DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease.

Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease.

A BAF-fling connection to RIPK1.

Inflammasome signaling in colorectal cancer.

Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.

PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality.

Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology.

Humans pIKK-up NLRP3 to skip NEK7.

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19.

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression.

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines.

AIM2 sensors mediate immunity to infection in hepatocytes.

CD47 halts -deficient neutrophils from provoking lethal inflammation.