Department of Advanced Nuclear Medicine Sciences,
Institute for Quantum Medical Science,
Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science
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Synthesis of two novel [F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain.
Organic & biomolecular chemistry Sep, 2018 | Pubmed ID: 30206613
Unexpected decrease in in vivo binding of [H]QNB in the mouse cerebral cortex in the developing brain - A comparison with [C]NMPB.
Nuclear medicine and biology Dec, 2018 | Pubmed ID: 30380462
Synthesis and evaluation of 4-(2-fluoro-4-[C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain.
Bioorganic & medicinal chemistry Feb, 2019 | Pubmed ID: 30611634
Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation.
Chemical communications (Cambridge, England) Apr, 2019 | Pubmed ID: 30810133
Correction: Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation.
Chemical communications (Cambridge, England) Apr, 2019 | Pubmed ID: 30855058
Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[C]carboxylate.
Bioorganic & medicinal chemistry Aug, 2019 | Pubmed ID: 31278005
PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder.
Frontiers of medicine Oct, 2019 | Pubmed ID: 31321611
I-IITM and At-AITM: Two Novel Small-Molecule Radiopharmaceuticals Targeting Oncoprotein Metabotropic Glutamate Receptor 1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Feb, 2020 | Pubmed ID: 31451486
Synthesis and evaluation of 6-(C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.
Bioorganic & medicinal chemistry letters Feb, 2020 | Pubmed ID: 31879207
Radiosynthesis of [thiocarbonyl-C]disulfiram and its first PET study in mice.
Bioorganic & medicinal chemistry letters Mar, 2020 | Pubmed ID: 32014383
Marriage of black phosphorus and Cu as effective photothermal agents for PET-guided combination cancer therapy.
Nature communications Jun, 2020 | Pubmed ID: 32513979
[C]phosgene: Synthesis and application for development of PET radiotracers.
Nuclear medicine and biology Jan, 2021 | Pubmed ID: 32546396
Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[C]methoxyphenethyl)pyridazin-3(2H)-one, a C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.
Bioorganic & medicinal chemistry letters Aug, 2020 | Pubmed ID: 32631531
Synthesis and preliminary evaluation of novel C-labeled GluN2B-selective NMDA receptor negative allosteric modulators.
Acta pharmacologica Sinica Mar, 2021 | Pubmed ID: 32661351
3-(Cyclopropylmethyl)-7-((4-(4-[C]methoxyphenyl)piperidin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine: Synthesis and preliminary evaluation for PET imaging of metabotropic glutamate receptor subtype 2.
Bioorganic & medicinal chemistry letters Dec, 2020 | Pubmed ID: 32941990
Radiosynthesis and evaluation of 4-(6-[F]Fluoro-4-(5-isopropoxy-1-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2.
RSC medicinal chemistry Jun, 2020 | Pubmed ID: 33479667
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy.
Journal for immunotherapy of cancer Jun, 2021 | Pubmed ID: 34148865
Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint.
RSC chemical biology Oct, 2020 | Pubmed ID: 34458761
Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [F]T-401 and PET.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Apr, 2022 | Pubmed ID: 34727758
Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.
Neurotoxicity research Feb, 2022 | Pubmed ID: 34981453
Brain 5-HT receptor binding and its neural network related to behavioral inhibition system.
Brain imaging and behavior Jun, 2022 | Pubmed ID: 35006540
First-in-human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with F-T-401.
European journal of nuclear medicine and molecular imaging Jul, 2022 | Pubmed ID: 35022846
Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells.
ACS omega Jan, 2022 | Pubmed ID: 35036703
Characterization and Stabilization of a New Cu-Labeled Anti-EGFR Antibody NCAB001 for the Early Detection of Pancreatic Cancer with Positron Emission Tomography.
Pharmaceutics Dec, 2021 | Pubmed ID: 35056963
Automated radiosynthesis of [ C]MTP38-a phosphodiesterase 7 imaging tracer-using [ C]hydrogen cyanide for clinical applications.
Journal of labelled compounds & radiopharmaceuticals May, 2022 | Pubmed ID: 35122288
Identification and quantitative structure-activity relationship assessment of trace chemical impurities contained in the therapeutic formulation of [Cu]Cu-ATSM.
Nuclear medicine and biology , 2022 | Pubmed ID: 35168008
Synthesis of [C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase.
EJNMMI radiopharmacy and chemistry Mar, 2022 | Pubmed ID: 35290562
Development of Novel Pt-Labeled Hoechst33258: Pt Is More Suitable than In for Targeting DNA.
Journal of medicinal chemistry Apr, 2022 | Pubmed ID: 35358392
Correction to: First‑in‑human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with F‑T‑401.
European journal of nuclear medicine and molecular imaging Jul, 2022 | Pubmed ID: 35403863
Rapid 'on-column' preparation of hydrogen [C]cyanide from [C]methyl iodide [C]formaldehyde.
Chemical science Mar, 2022 | Pubmed ID: 35432866
A novel monoacylglycerol lipase-targeted F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.
Acta pharmacologica Sinica Nov, 2022 | Pubmed ID: 35513432
PET-based classification of corticobasal syndrome.
Parkinsonism & related disorders May, 2022 | Pubmed ID: 35533530
Scandium Triflate-Catalyzed -[F]Fluoroalkylation of Aryl- Or Heteroaryl-Amines with [F]Epifluorohydrin under Mild Conditions.
Organic letters Jun, 2022 | Pubmed ID: 35613453
In Vitro Tumor Cell-Binding Assay to Select High-Binding Antibody and Predict Therapy Response for Personalized Cu-Intraperitoneal Radioimmunotherapy against Peritoneal Dissemination of Pancreatic Cancer: A Feasibility Study.
International journal of molecular sciences May, 2022 | Pubmed ID: 35628616
PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy.
Materials today. Bio Jun, 2022 | Pubmed ID: 35637855
Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.
Journal of medicinal chemistry Jul, 2022 | Pubmed ID: 35762919
A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model.
European journal of nuclear medicine and molecular imaging Nov, 2022 | Pubmed ID: 35798978
C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain.
Bioconjugate chemistry Sep, 2022 | Pubmed ID: 35951365
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy.
Movement disorders : official journal of the Movement Disorder Society Oct, 2022 | Pubmed ID: 36041211
A Machine Learning-Based Approach to Discrimination of Tauopathies Using [ F]PM-PBB3 PET Images.
Movement disorders : official journal of the Movement Disorder Society Nov, 2022 | Pubmed ID: 36054492
Acetamidobenzoxazolone scaffold as a promising translocator protein (18 kDa, TSPO) marker for neuroinflammation imaging: Advancement in last decennial period.
Drug development research Nov, 2022 | Pubmed ID: 36074736
Precise quantitative evaluation of pharmacokinetics of cisplatin using a radio-platinum tracer in tumor-bearing mice.
Nuclear medicine communications Nov, 2022 | Pubmed ID: 36120823
Assessment of cholesterol homeostasis in the living human brain.
Science translational medicine Oct, 2022 | Pubmed ID: 36197966
Dynamic imaging analysis reveals Auger electron-emitting radio-cisplatin induces DNA damage depending on the cell cycle.
Biochemical and biophysical research communications Dec, 2022 | Pubmed ID: 36410278
An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with F-PM-PBB3 (F-APN-1607).
NeuroImage Dec, 2022 | Pubmed ID: 36427751
Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia.
Schizophrenia bulletin Dec, 2022 | Pubmed ID: 36458958
Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy.
Journal of the neurological sciences Jan, 2023 | Pubmed ID: 36473346
Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein -8 (TARP -8) in the brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2023 | Pubmed ID: 36655318
Lulu Zhang*,1,
Siqi Zhang*,2,
Wenyu Wu1,
Xingkai Wang2,
Jieting Shen2,
Dongyuan Wang4,
Kuan Hu*,2,3,
Ming-Rong Zhang*,3,
Feng Wang*,1,
Rui Wang*,2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University,
2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,
3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology,
4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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