Balaji Narasimhan

Mechanistic relationships between polymer microstructure and drug release kinetics in bioerodible polyanhydrides.

Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery.

Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres.

Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres.

Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms.

Characterization of fate and transport of isoxaflutole, a soil-applied corn herbicide, in surface water using a watershed model.

Parallel synthesis and high throughput dissolution testing of biodegradable polyanhydride copolymers.

Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism.

Problem-based learning biotechnology courses in chemical engineering.

Protein stability in the presence of polymer degradation products: consequences for controlled release formulations.

Amphiphilic polyanhydrides for protein stabilization and release.

The role of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres.

Immunomodulatory biomaterials.

Vaccine adjuvants: current challenges and future approaches.

Combinatorial design of biomaterials for drug delivery: opportunities and challenges.

Polymer chemistry influences monocytic uptake of polyanhydride nanospheres.

Cobalt ferrite nanocrystals: out-performing magnetotactic bacteria.

High throughput cell-based screening of biodegradable polyanhydride libraries.

The simultaneous effect of polymer chemistry and device geometry on the in vitro activation of murine dendritic cells.

Effect of polymer chemistry and fabrication method on protein release and stability from polyanhydride microspheres.

Combinatorial/high throughput methods for the determination of polyanhydride phase behavior.

Tracking chemical processing pathways in combinatorial polymer libraries via data mining.

Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis antigens.

Lipocalin-2-loaded Amphiphilic Polyanhydride Microparticles Accelerate Cell Migration.

Protein adsorption on biodegradable polyanhydride microparticles.

Mathematical modeling of polymer erosion: consequences for drug delivery.

Identifying factors controlling protein release from combinatorial biomaterial libraries via hybrid data mining methods.

Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases.

Polyanhydride microparticles enhance dendritic cell antigen presentation and activation.

A novel high throughput method to investigate polymer dissolution.

Amphiphilic polyanhydride films promote neural stem cell adhesion and differentiation.

Activation of innate immune responses in a pathogen-mimicking manner by amphiphilic polyanhydride nanoparticle adjuvants.

Mannose-functionalized "pathogen-like" polyanhydride nanoparticles target C-type lectin receptors on dendritic cells.

Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants.

Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using "pathogen-like" amphiphilic polyanhydride nanoparticles.

Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation.

Single immunization with a suboptimal antigen dose encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses.

Characterizing the antitumor response in mice treated with antigen-loaded polyanhydride microparticles.

Block copolymer-quantum dot micelles for multienzyme colocalization.

Evaluation of biocompatibility and administration site reactogenicity of polyanhydride-particle-based platform for vaccine delivery.

Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles.

Functionalization of polyanhydride microparticles with di-mannose influences uptake by and intracellular fate within dendritic cells.

Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery.

Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents.

Materials-based strategies for multi-enzyme immobilization and co-localization: A review.

Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.

A systems approach to designing next generation vaccines: combining α-galactose modified antigens with nanoparticle platforms.

Structural and antigenic stability of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles.

Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours.

Mathematical models in drug delivery: how modeling has shaped the way we design new drug delivery systems.

Effect of nanovaccine chemistry on humoral immune response kinetics and maturation.

Pulmonary biodistribution and cellular uptake of intranasally administered monodisperse particles.

Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity.

Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.

Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Nano-enabled delivery of diverse payloads across complex biological barriers.

Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation.

Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery.

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.

Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses.

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.

Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs.

The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response.

Polyanhydride nanovaccine against swine influenza virus in pigs.

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.

Functionalization promotes pathogen-mimicking characteristics of polyanhydride nanoparticle adjuvants.

Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases.

Emerging trends in the immunotherapy of pancreatic cancer.

Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics.

A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers.

A polyanhydride-based implantable single dose vaccine platform for long-term immunity.

pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles.

Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf.

Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity.

Automated High-Throughput Synthesis of Protein-Loaded Polyanhydride Nanoparticle Libraries.

Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine.

Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections.

Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases.

Surface engineered polyanhydride-based oral subunit nanovaccine for poultry.

Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections.

Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice.

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.

Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of infection.

Safety and biocompatibility of injectable vaccine adjuvants composed of thermogelling block copolymer gels.

STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells.

Effective mosaic-based nanovaccines against avian influenza in poultry.

Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine.

Sustained antigen release polyanhydride-based vaccine platform for immunization against bovine brucellosis.

Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague.

Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves.

Development of a subcutaneous ear implant to deliver an anaplasmosis vaccine to dairy steers.

High-Throughput Synthesis and Screening of Rapidly Degrading Polyanhydride Nanoparticles.

A single dose polyanhydride-based nanovaccine against paratuberculosis infection.

Chitosan-adjuvanted Salmonella subunit nanoparticle vaccine for poultry delivered through drinking water and feed.

Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β.

Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues.

Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8 T Cell Memory and Delayed Tumor Progression.

Corrigendum to: Development of a subcutaneous ear implant to deliver an anaplasmosis vaccine to dairy steers.

Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.

Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkinson's Disease Patients.

Applications of Nanovaccines for Disease Prevention in Cattle.

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy while Inducing Low Inflammation.

Polyanhydride Nanoparticle Interactions with Host Serum Proteins and Their Effects on Bone Marrow Derived Macrophage Activation.

Synthesis and Characterization of Rapidly Degrading Polyanhydrides as Vaccine Adjuvants.

A single dose polyanhydride-based nanovaccine against paratuberculosis infection.

Prefusion F-Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus.

Single-dose combination nanovaccine induces both rapid and durable humoral immunity and toxin neutralizing antibody responses against Bacillus anthracis.